Chenodeoxycholic Acid Modulates Bile Acid Synthesis Independent of Fibroblast Growth Factor 19 in Primary Human Hepatocytes

por Johansson, Helene, Søndergaard, Jonas Nørskov, Jorns, Carl, Kutter, Claudia, Ellis, Ewa C. S.
Publicado 2021

Increased Prevalence of Alpha-1-Antitrypsin Deficiency in Patients with Biliary Tract Cancer and Its Associated Clinicopathological Features

por Cornillet, Martin, Zemack, Helen, Jansson, Hannes, Sparrelid, Ernesto, Ellis, Ewa, Björkström, Niklas K.
Publicado 2023

Maintenance of Hepatic Functions in Primary Human Hepatocytes Cultured on Xeno-Free and Chemical Defined Human Recombinant Laminins

por Watanabe, Masaaki, Zemack, Helen, Johansson, Helene, Hagbard, Louise, Jorns, Carl, Li, Meng, Ellis, Ewa
Publicado 2016

Gene Editing Correction of a Urea Cycle Defect in Organoid Stem Cell Derived Hepatocyte-like Cells

por Zabulica, Mihaela, Jakobsson, Tomas, Ravaioli, Francesco, Vosough, Massoud, Gramignoli, Roberto, Ellis, Ewa, Rooyackers, Olav, Strom, Stephen C.
Publicado 2021

In Situ Characterization of Intrahepatic Non-Parenchymal Cells in PSC Reveals Phenotypic Patterns Associated with Disease Severity

por Berglin, Lena, Bergquist, Annika, Johansson, Helene, Glaumann, Hans, Jorns, Carl, Lunemann, Sebastian, Wedemeyer, Heiner, Ellis, Ewa C., Björkström, Niklas K.
Publicado 2014

Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver

por Gensous, Noémie, Ravaioli, Francesco, Pirazzini, Chiara, Gramignoli, Roberto, Ellis, Ewa, Storci, Gianluca, Capri, Miriam, Strom, Stephen, Laconi, Ezio, Franceschi, Claudio, Garagnani, Paolo, Marongiu, Fabio, Bacalini, Maria Giulia
Publicado 2020

Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver

por Hildebrandt, Franziska, Andersson, Alma, Saarenpää, Sami, Larsson, Ludvig, Van Hul, Noémi, Kanatani, Sachie, Masek, Jan, Ellis, Ewa, Barragan, Antonio, Mollbrink, Annelie, Andersson, Emma R., Lundeberg, Joakim, Ankarklev, Johan
Publicado 2021

Mice with Chimeric Livers Are an Improved Model for Human Lipoprotein Metabolism

por Ellis, Ewa C. S., Nauglers, Scott, Parini, Paolo, Mörk, Lisa-Mari, Jorns, Carl, Zemack, Helen, Sandblom, Anita Lövgren, Björkhem, Ingemar, Ericzon, Bo-Göran, Wilson, Elizabeth M., Strom, Stephen C., Grompe, Markus
Publicado 2013

Guide to the Assessment of Mature Liver Gene Expression in Stem Cell-Derived Hepatocytes

por Zabulica, Mihaela, Srinivasan, Raghuraman C., Vosough, Massoud, Hammarstedt, Christina, Wu, Tingting, Gramignoli, Roberto, Ellis, Ewa, Kannisto, Kristina, Collin de l'Hortet, Alexandra, Takeishi, Kazuki, Soto-Gutierrez, Alejandro, Strom, Stephen C.
Publicado 2019

Procurement and Evaluation of Hepatocytes for Transplantation From Neonatal Donors After Circulatory Death

por Bluhme, Emil, Henckel, Ewa, Gramignoli, Roberto, Kjellin, Therese, Hammarstedt, Christina, Nowak, Greg, Karadagi, Ahmad, Johansson, Helene, Jynge, Öystein, Söderström, Maria, Fischler, Björn, Strom, Stephen, Ellis, Ewa, Hallberg, Boubou, Jorns, Carl
Publicado 2022

Exogenous alpha 1-antitrypsin down-regulates SERPINA1 expression

por Karadagi, Ahmad, Johansson, Helene, Zemack, Helen, Salipalli, Sandeep, Mörk, Lisa-Mari, Kannisto, Kristina, Jorns, Carl, Gramignoli, Roberto, Strom, Stephen, Stokkeland, Knut, Ericzon, Bo-Göran, Jonigk, Danny, Janciauskiene, Sabina, Nowak, Greg, Ellis, Ewa C. S.
Publicado 2017

Systemic modified messenger RNA for replacement therapy in alpha 1-antitrypsin deficiency

por Karadagi, Ahmad, Cavedon, Alex G., Zemack, Helen, Nowak, Greg, Eybye, Marianne E., Zhu, Xuling, Guadagnin, Eleonora, White, Rebecca A., Rice, Lisa M., Frassetto, Andrea L., Strom, Stephen, Jorns, Carl, Martini, Paolo G. V., Ellis, Ewa
Publicado 2020

DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome

por Hankeova, Simona, Salplachta, Jakub, Zikmund, Tomas, Kavkova, Michaela, Van Hul, Noémi, Brinek, Adam, Smekalova, Veronika, Laznovsky, Jakub, Dawit, Feven, Jaros, Josef, Bryja, Vítězslav, Lendahl, Urban, Ellis, Ewa, Nemeth, Antal, Fischler, Björn, Hannezo, Edouard, Kaiser, Jozef, Andersson, Emma Rachel
Publicado 2021

Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice

por Giannisis, Andreas, Patra, Kalicharan, Edlund, Anna K., Nieto, Lur Agirrezabala, Benedicto-Gras, Joan, Moussaud, Simon, de la Rosa, Andrés, Twohig, Daniel, Bengtsson, Tore, Fu, Yuan, Bu, Guojun, Bial, Greg, Foquet, Lander, Hammarstedt, Christina, Strom, Stephen, Kannisto, Kristina, Raber, Jacob, Ellis, Ewa, Nielsen, Henrietta M.
Publicado 2022

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

por Copple, Ian M., den Hollander, Wouter, Callegaro, Giulia, Mutter, Fiona E., Maggs, James L., Schofield, Amy L., Rainbow, Lucille, Fang, Yongxiang, Sutherland, Jeffrey J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Fenwick, Stephen W., Goldring, Christopher E., van de Water, Bob, Stevens, James L., Park, B. Kevin
Publicado 2018

Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging

por Adori, Csaba, Daraio, Teresa, Kuiper, Raoul, Barde, Swapnali, Horvathova, Lubica, Yoshitake, Takashi, Ihnatko, Robert, Valladolid-Acebes, Ismael, Vercruysse, Pauline, Wellendorf, Ashley M., Gramignoli, Roberto, Bozoky, Bela, Kehr, Jan, Theodorsson, Elvar, Cancelas, Jose A., Mravec, Boris, Jorns, Carl, Ellis, Ewa, Mulder, Jan, Uhlén, Mathias, Bark, Christina, Hökfelt, Tomas
Publicado 2021

Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations

por Andersson, Emma R., Chivukula, Indira V., Hankeova, Simona, Sjöqvist, Marika, Tsoi, Yat Long, Ramsköld, Daniel, Masek, Jan, Elmansuri, Aiman, Hoogendoorn, Anita, Vazquez, Elenae, Storvall, Helena, Netušilová, Julie, Huch, Meritxell, Fischler, Björn, Ellis, Ewa, Contreras, Adriana, Nemeth, Antal, Chien, Kenneth C., Clevers, Hans, Sandberg, Rickard, Bryja, Vitezslav, Lendahl, Urban
Publicado 2018

Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2

por Olayanju, Adedamola, Copple, Ian M., Bryan, Holly K., Edge, George T., Sison, Rowena L., Wong, Min Wei, Lai, Zheng-Quan, Lin, Zhi-Xiu, Dunn, Karen, Sanderson, Christopher M., Alghanem, Ahmad F., Cross, Michael J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Malik, Hassan Z., Kitteringham, Neil R., Goldring, Christopher E., Park, B. Kevin
Publicado 2015

Insights From Liver‐Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR‐Agonist Pharmacodynamics in Humans

por Minniti, Mirko E., Pedrelli, Matteo, Vedin, Lise‐Lotte, Delbès, Anne‐Sophie, Denis, Raphaël G.P., Öörni, Katariina, Sala, Claudia, Pirazzini, Chiara, Thiagarajan, Divya, Nurmi, Harri J., Grompe, Markus, Mills, Kevin, Garagnani, Paolo, Ellis, Ewa C.S., Strom, Stephen C., Luquet, Serge H., Wilson, Elizabeth M., Bial, John, Steffensen, Knut R., Parini, Paolo
Publicado 2020

Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes

por Zabulica, Mihaela, Srinivasan, Raghuraman C., Akcakaya, Pinar, Allegri, Gabriella, Bestas, Burcu, Firth, Mike, Hammarstedt, Christina, Jakobsson, Tomas, Jakobsson, Towe, Ellis, Ewa, Jorns, Carl, Makris, Georgios, Scherer, Tanja, Rimann, Nicole, van Zuydam, Natalie R., Gramignoli, Roberto, Forslöw, Anna, Engberg, Susanna, Maresca, Marcello, Rooyackers, Olav, Thöny, Beat, Häberle, Johannes, Rosen, Barry, Strom, Stephen C.
Publicado 2021