Clade F AAVHSCs cross the blood brain barrier and transduce the central nervous system in addition to peripheral tissues following intravenous administration in nonhuman primates

por Ellsworth, Jeff L., Gingras, Jacinthe, Smith, Laura J., Rubin, Hillard, Seabrook, Tania A., Patel, Kruti, Zapata, Nicole, Olivieri, Kevin, O’Callaghan, Michael, Chlipala, Elizabeth, Morales, Pablo, Seymour, Albert
Publicado 2019

Molecular characterization of precise in vivo targeted gene integration in human cells using AAVHSC15

por Chen, Huei-Mei, Resendes, Rachel, Ghodssi, Azita, Sookiasian, Danielle, Tian, Michael, Dollive, Serena, Adamson-Small, Laura, Avila, Nancy, Tazearslan, Cagdas, Thompson, John F., Ellsworth, Jeff L., Francone, Omar, Seymour, Albert, Wright, Jason B.
Publicado 2020

Sustained Correction of a Murine Model of Phenylketonuria following a Single Intravenous Administration of AAVHSC15-PAH

por Ahmed, Seemin S., Rubin, Hillard, Wang, Minglun, Faulkner, Deiby, Sengooba, Arnold, Dollive, Serena N., Avila, Nancy, Ellsworth, Jeff L., Lamppu, Diana, Lobikin, Maria, Lotterhand, Jason, Adamson-Small, Laura, Wright, Teresa, Seymour, Albert, Francone, Omar L.
Publicado 2020

B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell matur...

por Dillon, Stacey R, Harder, Brandon, Lewis, Kenneth B, Moore, Margaret D, Liu, Hong, Bukowski, Thomas R, Hamacher, Nels B, Lantry, Megan M, Maurer, Mark, Krejsa, Cecile M, Ellsworth, Jeff L, Pederson, Susan, Elkon, Keith B, Wener, Mark H, Dall'Era, Maria, Gross, Jane A
Publicado 2010

Natural variations in AAVHSC16 significantly reduce liver tropism and maintain broad distribution to periphery and CNS

por Smith, Laura J., Schulman, Lindsay A., Smith, Samantha, Van Lieshout, Laura, Barnes, Carmen M., Behmoiras, Liana, Scarpitti, Meghan, Kivaa, Monicah, Duong, Khanh L., Benard, Ludo O., Ellsworth, Jeff L., Avila, Nancy, Faulkner, Deiby, Hayes, April, Lotterhand, Jason, Rivas, Jose Israel, Sengooba, Arnold V., Tzianabos, Alec, Seymour, Albert B., Francone, Omar L.
Publicado 2022