A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo

por Gupta, Nidhi, Fisker, Niels, Asselin, Marie-Claude, Lindholm, Marie, Rosenbohm, Christoph, Ørum, Henrik, Elmén, Joacim, Seidah, Nabil G., Straarup, Ellen Marie
Publicado 2010

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

por Elmén, Joacim, Thonberg, Håkan, Ljungberg, Karl, Frieden, Miriam, Westergaard, Majken, Xu, Yunhe, Wahren, Britta, Liang, Zicai, Ørum, Henrik, Koch, Troels, Wahlestedt, Claes
Publicado 2005

Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF

por Worm, Jesper, Stenvang, Jan, Petri, Andreas, Frederiksen, Klaus Stensgaard, Obad, Susanna, Elmén, Joacim, Hedtjärn, Maj, Straarup, Ellen Marie, Hansen, Jens Bo, Kauppinen, Sakari
Publicado 2009

Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver

por Elmén, Joacim, Lindow, Morten, Silahtaroglu, Asli, Bak, Mads, Christensen, Mette, Lind-Thomsen, Allan, Hedtjärn, Maj, Hansen, Jens Bo, Hansen, Henrik Frydenlund, Straarup, Ellen Marie, McCullagh, Keith, Kearney, Phil, Kauppinen, Sakari
Publicado 2008