Unraveling the complexities of cardiac remodeling and hypertrophy — High-content screening and computational modeling

por Elrod, John W., van Berlo, Jop H.
Publicado 2014

Reappraisal of metabolic dysfunction in neurodegeneration: Focus on mitochondrial function and calcium signaling

por Jadiya, Pooja, Garbincius, Joanne F., Elrod, John W.
Publicado 2021

MICU1-dependent mitochondrial calcium uptake regulates lung alveolar type 2 cell plasticity and lung regeneration

por Ali, Mir, Zhang, Xiaoying, LaCanna, Ryan, Tomar, Dhanendra, Elrod, John W., Tian, Ying
Publicado 2022

Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline

por Jadiya, Pooja, Cohen, Henry M., Kolmetzky, Devin W., Kadam, Ashlesha A., Tomar, Dhanendra, Elrod, John W.
Publicado 2023

Troglitazone, a PPAR-γ activator prevents endothelial cell adhesion molecule expression and lymphocyte adhesion mediated by TNF-α

por Sasaki, Makoto, Jordan, Paul, Welbourne, Tomas, Minagar, Alireza, Joh, Takashi, Itoh, Makoto, Elrod, John W, Alexander, J Steven
Publicado 2005

Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart

por Fuente, Sergio De La, Lambert, Jonathan P., Nichtova, Zuzana, Sanz, Celia Fernandez, Elrod, John W., Sheu, Shey-Shing, Csordás, György
Publicado 2018

MCU gain- and loss-of-function models define the duality of mitochondrial calcium uptake in heart failure

por Garbincius, Joanne F., Luongo, Timothy S., Lambert, Jonathan P., Mangold, Adam S., Murray, Emma K., Hildebrand, Alycia N., Jadiya, Pooja, Elrod, John W.
Publicado 2023

Astrocytic metabolic switch is a novel etiology for Cocaine and HIV-1 Tat-mediated neurotoxicity

por Natarajaseenivasan, Kalimuthusamy, Cotto, Bianca, Shanmughapriya, Santhanam, Lombardi, Alyssa A., Datta, Prasun K., Madesh, Muniswamy, Elrod, John W., Khalili, Kamel, Langford, Dianne
Publicado 2018

Mitochondrial sodium/calcium exchanger NCLX regulates glycolysis in astrocytes, impacting on cognitive performance

por Cabral-Costa, João Victor, Vicente-Gutiérrez, Carlos, Agulla, Jesús, Lapresa, Rebeca, Elrod, John W., Almeida, Ángeles, Bolaños, Juan P., Kowaltowski, Alicia J.
Publicado 2023

Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency

por Stein, Colleen S., Jadiya, Pooja, Zhang, Xiaoming, McLendon, Jared M., Abouassaly, Gabrielle M., Witmer, Nathan H., Anderson, Ethan J., Elrod, John W., Boudreau, Ryan L.
Publicado 2018

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

por Jadiya, Pooja, Kolmetzky, Devin W., Tomar, Dhanendra, Di Meco, Antonio, Lombardi, Alyssa A., Lambert, Jonathan P., Luongo, Timothy S., Ludtmann, Marthe H., Praticò, Domenico, Elrod, John W.
Publicado 2019

The mitochondrial calcium uniporter promotes arrhythmias caused by high-fat diet

por Joseph, Leroy C., Reyes, Michael V., Homan, Edwin A., Gowen, Blake, Avula, Uma Mahesh R., Goulbourne, Chris N., Wan, Elaine Y., Elrod, John W., Morrow, John P.
Publicado 2021

Endothelial Cell Cystathionine γ‐Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury

por Xia, Huijing, Li, Zhen, Sharp, Thomas E., Polhemus, David J., Carnal, Jean, Moles, Karl H., Tao, Ya‐Xiong, Elrod, John, Pfeilschifter, Josef, Beck, Karl‐Friedrich, Lefer, David J.
Publicado 2020

Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model

por Gibb, Andrew A., Murray, Emma K., Eaton, Deborah M., Huynh, Anh T., Tomar, Dhanendra, Garbincius, Joanne F., Kolmetzky, Devin W., Berretta, Remus M., Wallner, Markus, Houser, Steven R., Elrod, John W.
Publicado 2021

SLC25A23 augments mitochondrial Ca(2+) uptake, interacts with MCU, and induces oxidative stress–mediated cell death

por Hoffman, Nicholas E., Chandramoorthy, Harish C., Shanmughapriya, Santhanam, Zhang, Xueqian Q., Vallem, Sandhya, Doonan, Patrick J., Malliankaraman, Karthik, Guo, Shuchi, Rajan, Sudarsan, Elrod, John W., Koch, Walter J., Cheung, Joseph Y., Madesh, Muniswamy
Publicado 2014

Combining three independent pathological stressors induces a heart failure with preserved ejection fraction phenotype

por Li, Yijia, Kubo, Hajime, Yu, Daohai, Yang, Yijun, Johnson, Jaslyn P., Eaton, Deborah M., Berretta, Remus M., Foster, Michael, McKinsey, Timothy A., Yu, Jun, Elrod, John W., Chen, Xiongwen, Houser, Steven R.
Publicado 2023

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

por Karch, Jason, Kwong, Jennifer Q, Burr, Adam R, Sargent, Michelle A, Elrod, John W, Peixoto, Pablo M, Martinez-Caballero, Sonia, Osinska, Hanna, Cheng, Emily H-Y, Robbins, Jeffrey, Kinnally, Kathleen W, Molkentin, Jeffery D
Publicado 2013

TMEM65 regulates NCLX-dependent mitochondrial calcium efflux

por Garbincius, Joanne F., Salik, Oniel, Cohen, Henry M., Choya-Foces, Carmen, Mangold, Adam S., Makhoul, Angelina D., Schmidt, Anna E., Khalil, Dima Y., Doolittle, Joshua J., Wilkinson, Anya S., Murray, Emma K., Lazaropoulos, Michael P., Hildebrand, Alycia N., Tomar, Dhanendra, Elrod, John W.
Publicado 2023

Diabetes impairs cardioprotective function of endothelial progenitor cell-derived extracellular vesicles via H3K9Ac inhibition

por Huang, Grace, Cheng, Zhongjian, Hildebrand, Alycia, Wang, Chunlin, Cimini, Maria, Roy, Rajika, Lucchese, Anna Maria, Benedict, Cindy, Mallaredy, Vandana, Magadum, Ajit, Joladarashi, Darukeshwara, Thej, Charan, Gonzalez, Carolina, Trungcao, May, Garikipati, Venkata Naga Srikanth, Elrod, John W., Koch, Walter J., Kishore, Raj
Publicado 2022

Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation

por Lombardi, Alyssa A., Gibb, Andrew A., Arif, Ehtesham, Kolmetzky, Devin W., Tomar, Dhanendra, Luongo, Timothy S., Jadiya, Pooja, Murray, Emma K., Lorkiewicz, Pawel K., Hajnóczky, György, Murphy, Elizabeth, Arany, Zoltan P., Kelly, Daniel P., Margulies, Kenneth B., Hill, Bradford G., Elrod, John W.
Publicado 2019