Intricate Regulatory Mechanisms of the Anaphase-Promoting Complex/Cyclosome and Its Role in Chromatin Regulation

por Bodrug, Tatyana, Welsh, Kaeli A., Hinkle, Megan, Emanuele, Michael J., Brown, Nicholas G.
Publicado 2021

Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin

por Vorozhko, Valeriya V., Emanuele, Michael J., Kallio, Marko J., Stukenberg, P. Todd, Gorbsky, Gary J.
Publicado 2007

FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal-like Breast Cancer

por Arceci, Anthony, Bonacci, Thomas, Wang, Xianxi, Stewart, Kyle, Damrauer, Jeffrey S., Hoadley, Katherine A., Emanuele, Michael J.
Publicado 2019

Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly

por Emanuele, Michael J., Lan, Weijie, Jwa, Miri, Miller, Stephanie A., Chan, Clarence S.M., Stukenberg, P. Todd
Publicado 2008

A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells

por Ly, Tony, Ahmad, Yasmeen, Shlien, Adam, Soroka, Dominique, Mills, Allie, Emanuele, Michael J, Stratton, Michael R, Lamond, Angus I
Publicado 2014

AtomNet-Aided OTUD7B Inhibitor Discovery and Validation

por Chen, Jianfeng, Bolhuis, Derek L., Laggner, Christian, Kong, Deyu, Yu, Le, Wang, Xiaodong, Emanuele, Michael J., Brown, Nicholas G., Liu, Pengda
Publicado 2023

Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

por Enrico, Taylor P, Stallaert, Wayne, Wick, Elizaveta T, Ngoi, Peter, Wang, Xianxi, Rubin, Seth M, Brown, Nicholas G, Purvis, Jeremy E, Emanuele, Michael J
Publicado 2021

Set2 methyltransferase facilitates cell cycle progression by maintaining transcriptional fidelity

por Dronamraju, Raghuvar, Jha, Deepak Kumar, Eser, Umut, Adams, Alexander T, Dominguez, Daniel, Choudhury, Rajarshi, Chiang, Yun-Chen, Rathmell, W Kimryn, Emanuele, Michael J, Churchman, L Stirling, Strahl, Brian D
Publicado 2018

Inhibition of CDK1 by RO-3306 Exhibits Anti-Tumorigenic Effects in Ovarian Cancer Cells and a Transgenic Mouse Model of Ovarian Cancer

por Huang, Yu, Fan, Yali, Zhao, Ziyi, Zhang, Xin, Tucker, Katherine, Staley, Allison, Suo, Hongyan, Sun, Wenchuan, Shen, Xiaochang, Deng, Boer, Pierce, Stuart R., West, Lindsay, Yin, Yajie, Emanuele, Michael J., Zhou, Chunxiao, Bae-Jump, Victoria
Publicado 2023

Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control

por Mouery, Ryan D, Hsu, Carolyn, Bonacci, Thomas, Bolhuis, Derek L, Wang, Xianxi, Mills, Christine A, Toomer, E Drew, Canterbury, Owen G, Robertson, Kevin C, Branigan, Timothy B, Brown, Nicholas G, Herring, Laura E, Emanuele, Michael J
Publicado 2023

Functional conservation and divergence of the helix‐turn‐helix motif of E2 ubiquitin‐conjugating enzymes

por Welsh, Kaeli A, Bolhuis, Derek L, Nederstigt, Anneroos E, Boyer, Joshua, Temple, Brenda R S, Bonacci, Thomas, Gu, Li, Ordureau, Alban, Harper, J Wade, Steimel, Joshua P, Zhang, Qi, Emanuele, Michael J, Harrison, Joseph S, Brown, Nicholas G
Publicado 2021

Cell cycle oscillators underlying orderly proteolysis of E2F8

por Wasserman, Danit, Nachum, Sapir, Cohen, Meital, Enrico, Taylor P., Noach-Hirsh, Meirav, Parasol, Jasmin, Zomer-Polak, Sarit, Auerbach, Naomi, Sheinberger-Chorni, Evelin, Nevenzal, Hadas, Levi-Dadon, Nofar, Wang, Xianxi, Lahmi, Roxane, Michaely, Efrat, Gerber, Doron, Emanuele, Michael J., Tzur, Amit
Publicado 2020

Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming

por Martinez-Chacin, Raquel C., Bodrug, Tatyana, Bolhuis, Derek L., Kedziora, Katarzyna M., Bonacci, Thomas, Ordureau, Alban, Gibbs, Morgan E., Weissmann, Florian, Qiao, Renping, Grant, Gavin D., Cook, Jeanette G., Peters, Jan-Michael, Harper, J. Wade, Emanuele, Michael J., Brown, Nicholas G.
Publicado 2020

Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCF(Slmb) degron

por Gray, Kelsey M., Kaifer, Kevin A., Baillat, David, Wen, Ying, Bonacci, Thomas R., Ebert, Allison D., Raimer, Amanda C., Spring, Ashlyn M., Have, Sara ten, Glascock, Jacqueline J., Gupta, Kushol, Van Duyne, Gregory D., Emanuele, Michael J., Lamond, Angus I., Wagner, Eric J., Lorson, Christian L., Matera, A. Gregory
Publicado 2018

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

por Franks, Jennifer L., Martinez-Chacin, Raquel C., Wang, Xianxi, Tiedemann, Rochelle L., Bonacci, Thomas, Choudhury, Rajarshi, Bolhuis, Derek L., Enrico, Taylor P., Mouery, Ryan D., Damrauer, Jeffrey S., Yan, Feng, Harrison, Joseph S., Major, M. Ben, Hoadley, Katherine A., Suzuki, Aussie, Rothbart, Scott B., Brown, Nicholas G., Emanuele, Michael J.
Publicado 2020

Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)

por Bodrug, Tatyana, Welsh, Kaeli A., Bolhuis, Derek L., Paulаkonis, Ethan, Martinez-Chacin, Raquel C., Liu, Bei, Pinkin, Nicholas, Bonacci, Thomas, Cui, Liying, Xu, Pengning, Roscow, Olivia, Amann, Sascha Josef, Grishkovskaya, Irina, Emanuele, Michael J., Harrison, Joseph S., Steimel, Joshua P., Hahn, Klaus M., Zhang, Wei, Zhong, Ellen D., Haselbach, David, Brown, Nicholas G.
Publicado 2023