Dynamic studies of H-Ras•GTPγS interactions with nucleotide exchange factor Sos reveal a transient ternary complex formation in solution

por Vo, Uybach, Vajpai, Navratna, Embrey, Kevin J., Golovanov, Alexander P.
Publicado 2016

Segmental Isotope Labelling of an Individual Bromodomain of a Tandem Domain BRD4 Using Sortase A

por Williams, Felix P., Milbradt, Alexander G., Embrey, Kevin J., Bobby, Romel
Publicado 2016

Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence

por Vo, Uybach, Vajpai, Navratna, Flavell, Liz, Bobby, Romel, Breeze, Alexander L., Embrey, Kevin J., Golovanov, Alexander P.
Publicado 2016

Bromodomain Interactions with Acetylated Histone 4 Peptides in the BRD4 Tandem Domain: Effects on Domain Dynamics and Internal Flexibility

por Wernersson, Sven, Bobby, Romel, Flavell, Liz, Milbradt, Alexander G., Holdgate, Geoffrey A., Embrey, Kevin J., Akke, Mikael
Publicado 2022

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition

por Ogden, Tom E H, Yang, Ji-Chun, Schimpl, Marianne, Easton, Laura E, Underwood, Elizabeth, Rawlins, Philip B, McCauley, Michael M, Langelier, Marie-France, Pascal, John M, Embrey, Kevin J, Neuhaus, David
Publicado 2021

Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor

por Michaelides, Iacovos N., Collie, Gavin W., Börjesson, Ulf, Vasalou, Christina, Alkhatib, Omar, Barlind, Louise, Cheung, Tony, Dale, Ian L., Embrey, Kevin J., Hennessy, Edward J., Khurana, Puneet, Koh, Cheryl M., Lamb, Michelle L., Liu, Jianming, Moss, Thomas A., O’Neill, Daniel J., Phillips, Christopher, Shaw, Joseph, Snijder, Arjan, Storer, R. Ian, Stubbs, Christopher J., Han, Fujin, Li, Chengzhi, Qiao, Jingchuan, Sun, Dong-Qing, Wang, Jingwen, Wang, Peng, Yang, Wenzhen
Publicado 2023

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

por Cohen, E. Suzanne, Scott, Ian C., Majithiya, Jayesh B., Rapley, Laura, Kemp, Benjamin P., England, Elizabeth, Rees, D. Gareth, Overed-Sayer, Catherine L., Woods, Joanne, Bond, Nicholas J., Veyssier, Christel Séguy, Embrey, Kevin J., Sims, Dorothy A., Snaith, Michael R., Vousden, Katherine A., Strain, Martin D., Chan, Denice T. Y., Carmen, Sara, Huntington, Catherine E., Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E., Vaughan, Tristan J., Butler, Robin, Lowe, David C., Higazi, Daniel R., Corkill, Dominic J., May, Richard D., Sleeman, Matthew A., Mustelin, Tomas
Publicado 2015

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

por Tron, Adriana E., Belmonte, Matthew A., Adam, Ammar, Aquila, Brian M., Boise, Lawrence H., Chiarparin, Elisabetta, Cidado, Justin, Embrey, Kevin J., Gangl, Eric, Gibbons, Francis D., Gregory, Gareth P., Hargreaves, David, Hendricks, J. Adam, Johannes, Jeffrey W., Johnstone, Ricky W., Kazmirski, Steven L., Kettle, Jason G., Lamb, Michelle L., Matulis, Shannon M., Nooka, Ajay K., Packer, Martin J., Peng, Bo, Rawlins, Philip B., Robbins, Daniel W., Schuller, Alwin G., Su, Nancy, Yang, Wenzhan, Ye, Qing, Zheng, Xiaolan, Secrist, J. Paul, Clark, Edwin A., Wilson, David M., Fawell, Stephen E., Hird, Alexander W.
Publicado 2018