All change: protein conformation and the ubiquitination reaction cascade

por Riedinger, Christiane, Endicott, Jane A
Publicado 2009

Structural insights into the functional diversity of the CDK–cyclin family

por Wood, Daniel J., Endicott, Jane A.
Publicado 2018

Emerging approaches to CDK inhibitor development, a structural perspective

por Hope, Ian, Endicott, Jane A., Watt, Jessica E.
Publicado 2022

The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508

por Baumli, Sonja, Hole, Alison J., Noble, Martin E. M., Endicott, Jane A.
Publicado 2012

A new crystal form of Lys48-linked diubiquitin

por Trempe, Jean-François, Brown, Nicholas R., Noble, Martin E. M., Endicott, Jane A.
Publicado 2010

An Inhibitor’s-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States

por Echalier, Aude, Hole, Alison J., Lolli, Graziano, Endicott, Jane A., Noble, Martin E. M.
Publicado 2014

The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b

por Baumli, Sonja, Hole, Alison J., Wang, Lan-Zhen, Noble, Martin E.M., Endicott, Jane A.
Publicado 2012

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

por Brown, Nicholas R., Korolchuk, Svitlana, Martin, Mathew P., Stanley, Will A., Moukhametzianov, Rouslan, Noble, Martin E. M., Endicott, Jane A.
Publicado 2015

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition

por Wood, Daniel J., Korolchuk, Svitlana, Tatum, Natalie J., Wang, Lan-Zhen, Endicott, Jane A., Noble, Martin E.M., Martin, Mathew P.
Publicado 2019

Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12

por Riedinger, Christiane, Boehringer, Jonas, Trempe, Jean-Francois, Lowe, Edward D., Brown, Nicholas R., Gehring, Kalle, Noble, Martin E. M., Gordon, Colin, Endicott, Jane A.
Publicado 2010

Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity

por Hole, Alison J., Baumli, Sonja, Shao, Hao, Shi, Shenhua, Huang, Shiliang, Pepper, Chris, Fischer, Peter M., Wang, Shudong, Endicott, Jane A., Noble, Martin E.
Publicado 2012

Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1

por Rowland, Rhianna J., Heath, Richard, Maskell, Daniel, Thompson, Rebecca F., Ranson, Neil A., Blaza, James N., Endicott, Jane A., Noble, Martin E. M., Salamina, Marco
Publicado 2023

Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation

por Boehringer, Jonas, Riedinger, Christiane, Paraskevopoulos, Konstantinos, Johnson, Eachan O. D., Lowe, Edward D., Khoudian, Christina, Smith, Dominique, Noble, Martin E. M., Gordon, Colin, Endicott, Jane A.
Publicado 2012

Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Acti...

por Shao, Hao, Shi, Shenhua, Huang, Shiliang, Hole, Alison J., Abbas, Abdullahi Y., Baumli, Sonja, Liu, Xiangrui, Lam, Frankie, Foley, David W., Fischer, Peter M., Noble, Martin, Endicott, Jane A., Pepper, Chris, Wang, Shudong
Publicado 2013

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System

por Hallett, Stephen T., Pastok, Martyna W., Morgan, R. Marc L., Wittner, Anita, Blundell, Katie L.I.M., Felletar, Ildiko, Wedge, Stephen R., Prodromou, Chrisostomos, Noble, Martin E.M., Pearl, Laurence H., Endicott, Jane A.
Publicado 2017

Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach

por Miller, Duncan C., Martin, Mathew P., Adhikari, Santosh, Brennan, Alfie, Endicott, Jane A., Golding, Bernard T., Hardcastle, Ian R., Heptinstall, Amy, Hobson, Stephen, Jennings, Claire, Molyneux, Lauren, Ng, Yvonne, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine
Publicado 2018

Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation

por Salamina, Marco, Montefiore, Bailey C., Liu, Mengxi, Wood, Daniel J., Heath, Richard, Ault, James R., Wang, Lan-Zhen, Korolchuk, Svitlana, Baslé, Arnaud, Pastok, Martyna W., Reeks, Judith, Tatum, Natalie J., Sobott, Frank, Arold, Stefan T., Pagano, Michele, Noble, Martin E.M., Endicott, Jane A.
Publicado 2021

Identification and Characterization of an Irreversible Inhibitor of CDK2

por Anscombe, Elizabeth, Meschini, Elisa, Mora-Vidal, Regina, Martin, Mathew P., Staunton, David, Geitmann, Matthis, Danielson, U. Helena, Stanley, Will A., Wang, Lan Z., Reuillon, Tristan, Golding, Bernard T., Cano, Celine, Newell, David R., Noble, Martin E.M., Wedge, Stephen R., Endicott, Jane A., Griffin, Roger J.
Publicado 2015

Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites—Halogenated Probes of Druglike and Peptide-like Molecular Interactions

por Davison, Gemma, Martin, Mathew P., Turberville, Shannon, Dormen, Selma, Heath, Richard, Heptinstall, Amy B., Lawson, Marie, Miller, Duncan C., Ng, Yi Min, Sanderson, James N., Hope, Ian, Wood, Daniel J., Cano, Céline, Endicott, Jane A., Hardcastle, Ian R., Noble, Martin E. M., Waring, Michael J.
Publicado 2022

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines

por Coxon, Christopher R., Anscombe, Elizabeth, Harnor, Suzannah J., Martin, Mathew P., Carbain, Benoit, Golding, Bernard T., Hardcastle, Ian R., Harlow, Lisa K., Korolchuk, Svitlana, Matheson, Christopher J., Newell, David R., Noble, Martin E. M., Sivaprakasam, Mangaleswaran, Tudhope, Susan J., Turner, David M., Wang, Lan Z., Wedge, Stephen R., Wong, Christopher, Griffin, Roger J., Endicott, Jane A., Cano, Céline
Publicado 2016