The Urokinase Receptor (uPAR) as a “Trojan Horse” in Targeted Cancer Therapy: Challenges and Opportunities

por Metrangolo, Virginia, Ploug, Michael, Engelholm, Lars H.
Publicado 2021

Gender Affects Skin Wound Healing in Plasminogen Deficient Mice

por Rønø, Birgitte, Engelholm, Lars Henning, Lund, Leif Røge, Hald, Andreas
Publicado 2013

The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)

por MELANDER, MARIA C., JÜRGENSEN, HENRIK J., MADSEN, DANIEL H., ENGELHOLM, LARS H., BEHRENDT, NIELS
Publicado 2015

Osteosarcoma and Metastasis Associated Bone Degradation—A Tale of Osteoclast and Malignant Cell Cooperativity

por Nørregaard, Kirstine Sandal, Jürgensen, Henrik Jessen, Gårdsvoll, Henrik, Engelholm, Lars Henning, Behrendt, Niels, Søe, Kent
Publicado 2021

Inhibitory Monoclonal Antibodies against Mouse Proteases Raised in Gene-Deficient Mice Block Proteolytic Functions in vivo

por Lund, Ida K., Rasch, Morten G., Ingvarsen, Signe, Pass, Jesper, Madsen, Daniel H., Engelholm, Lars H., Behrendt, Niels, Høyer-Hansen, Gunilla
Publicado 2012

CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets()

por Jürgensen, Henrik J., Silva, Lakmali M., Krigslund, Oliver, van Putten, Sander, Madsen, Daniel H., Behrendt, Niels, Engelholm, Lars H., Bugge, Thomas H.
Publicado 2019

Uncovering mediators of collagen degradation in the tumor microenvironment

por Thorseth, Marie-Louise, Carretta, Marco, Jensen, Christina, Mølgaard, Kasper, Jürgensen, Henrik J., Engelholm, Lars H., Behrendt, Niels, Willumsen, Nicholas, Madsen, Daniel H.
Publicado 2022

Loss of miR-10a Activates Lpo and Collaborates with Activated Wnt Signaling in Inducing Intestinal Neoplasia in Female Mice

por Stadthagen, Gustavo, Tehler, Disa, Høyland-Kroghsbo, Nina Molin, Wen, Jiayu, Krogh, Anders, Jensen, Klaus T., Santoni-Rugiu, Eric, Engelholm, Lars H., Lund, Anders H.
Publicado 2013

The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target

por Çakılkaya, Pınar, Sørensen, Rikke Raagaard, Jürgensen, Henrik Jessen, Krigslund, Oliver, Gårdsvoll, Henrik, Nielsen, Christoffer F., Santoni-Rugiu, Eric, Behrendt, Niels, Engelholm, Lars H.
Publicado 2021

Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy

por Curino, Alejandro C., Engelholm, Lars H., Yamada, Susan S., Holmbeck, Kenn, Lund, Leif R., Molinolo, Alfredo A., Behrendt, Niels, Nielsen, Boye Schnack, Bugge, Thomas H.
Publicado 2005

Differential Actions of the Endocytic Collagen Receptor uPARAP/Endo180 and the Collagenase MMP-2 in Bone Homeostasis

por Madsen, Daniel H., Jürgensen, Henrik J., Ingvarsen, Signe, Melander, Maria C., Albrechtsen, Reidar, Hald, Andreas, Holmbeck, Kenn, Bugge, Thomas H., Behrendt, Niels, Engelholm, Lars H.
Publicado 2013

No Effect of NGAL/lipocalin-2 on Aggressiveness of Cancer in the MMTV-PyMT/FVB/N Mouse Model for Breast Cancer

por Cramer, Elisabeth P., Glenthøj, Andreas, Häger, Mattias, Juncker-Jensen, Anna, Engelholm, Lars H., Santoni-Rugiu, Eric, Lund, Leif R., Laerum, Ole D., Cowland, Jack B., Borregaard, Niels
Publicado 2012

Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment

por Fjæstad, Klaire Yixin, Rømer, Anne Mette Askehøj, Goitea, Victor, Johansen, Astrid Zedlitz, Thorseth, Marie-Louise, Carretta, Marco, Engelholm, Lars Henning, Grøntved, Lars, Junker, Niels, Madsen, Daniel Hargbøl
Publicado 2022

Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins

por Jürgensen, Henrik J., Nørregaard, Kirstine S., Sibree, Megan M., Santoni-Rugiu, Eric, Madsen, Daniel H., Wassilew, Katharina, Krustrup, Dorrit, Garred, Peter, Bugge, Thomas H., Engelholm, Lars H., Behrendt, Niels
Publicado 2019

Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs

por Rowe, R. Grant, Li, Xiao-Yan, Hu, Yuexian, Saunders, Thomas L., Virtanen, Ismo, de Herreros, Antonio Garcia, Becker, Karl-Friedrich, Ingvarsen, Signe, Engelholm, Lars H., Bommer, Guido T., Fearon, Eric R., Weiss, Stephen J.
Publicado 2009

Personalized B cell response to the Lactobacillus rhamnosus GG probiotic in healthy human subjects: a randomized trial

por Bornholdt, Jette, Broholm, Christa, Chen, Yun, Rago, Alfredo, Sloth, Stine, Hendel, Jakob, Melsæther, Cathrine, Müller, Christina V., Juul Nielsen, Maria, Strickertsson, Jesper, Engelholm, Lars, Vitting-Seerup, Kristoffer, Jensen, Kim B., Baker, Adam, Sandelin, Albin
Publicado 2020

Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis

por Ingvarsen, Signe Z., Gårdsvoll, Henrik, van Putten, Sander, Nørregaard, Kirstine S., Krigslund, Oliver, Meilstrup, Josephine A., Tran, Collin, Jürgensen, Henrik J., Melander, Maria C., Nielsen, Carsten H., Kjaer, Andreas, Bugge, Thomas H., Engelholm, Lars H., Behrendt, Niels
Publicado 2020

uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion

por Engelholm, Lars H., List, Karin, Netzel-Arnett, Sarah, Cukierman, Edna, Mitola, David J., Aaronson, Hannah, Kjøller, Lars, Larsen, Jørgen K., Yamada, Kenneth M., Strickland, Dudley K., Holmbeck, Kenn, Danø, Keld, Birkedal-Hansen, Henning, Behrendt, Niels, Bugge, Thomas H.
Publicado 2003

M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway

por Madsen, Daniel H., Leonard, Daniel, Masedunskas, Andrius, Moyer, Amanda, Jürgensen, Henrik Jessen, Peters, Diane E., Amornphimoltham, Panomwat, Selvaraj, Arul, Yamada, Susan S., Brenner, David A., Burgdorf, Sven, Engelholm, Lars H., Behrendt, Niels, Holmbeck, Kenn, Weigert, Roberto, Bugge, Thomas H.
Publicado 2013

The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers

por Nielsen, Christoffer Fagernæs, van Putten, Sander Maarten, Lund, Ida Katrine, Melander, Maria Carlsén, Nørregaard, Kirstine Sandal, Jürgensen, Henrik Jessen, Reckzeh, Kristian, Christensen, Kristine Rothaus, Ingvarsen, Signe Ziir, Gårdsvoll, Henrik, Jensen, Kamilla Ellermann, Hamerlik, Petra, Engelholm, Lars Henning, Behrendt, Niels
Publicado 2017