Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage

por Eoff, Robert L., Choi, Jeong-Yun, Guengerich, F. Peter
Publicado 2010

The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa

por Maddukuri, Leena, Ketkar, Amit, Eddy, Sarah, Zafar, Maroof K., Eoff, Robert L.
Publicado 2014

A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase β

por Gujarathi, Satheesh, Zafar, Maroof Khan, Liu, Xingui, Eoff, Robert L., Zheng, Guangrong
Publicado 2020

Kinetic Analysis of Human PrimPol DNA Polymerase Activity Reveals a Generally Error-Prone Enzyme Capable of Accurately Bypassing 7,8-Dihydro-8-oxo-2′-deoxyguanosine

por Zafar, Maroof K., Ketkar, Amit, Lodeiro, Maria F., Cameron, Craig E., Eoff, Robert L.
Publicado 2014

Human Rev1 polymerase disrupts G-quadruplex DNA

por Eddy, Sarah, Ketkar, Amit, Zafar, Maroof K., Maddukuri, Leena, Choi, Jeong-Yun, Eoff, Robert L.
Publicado 2014

Translesion DNA Synthesis by Human DNA Polymerase η on Templates Containing a Pyrimidopurinone Deoxyguanosine Adduct, 3-(2′-Deoxy-β-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-1...

por Stafford, Jennifer B., Eoff, Robert L., Kozekova, Albena, Rizzo, Carmelo J., Guengerich, F. Peter, Marnett, Lawrence J.
Publicado 2008

In Vitro Bypass of the Major Malondialdehyde- and Base Propenal-Derived DNA Adduct by Human Y-family DNA Polymerases κ, ι, and Rev1

por Maddukuri, Leena, Eoff, Robert L., Choi, Jeong-Yun, Rizzo, Carmelo J., Guengerich, F. Peter, Marnett, Lawrence J.
Publicado 2010

Structural and Functional Analysis of Sulfolobus solfataricus Y-Family DNA Polymerase Dpo4-Catalyzed Bypass of the Malondialdehyde−Deoxyguanosine Adduct(,)

por Eoff, Robert L., Stafford, Jennifer B., Szekely, Jozsef, Rizzo, Carmelo J., Egli, Martin, Guengerich, F. Peter, Marnett, Lawrence J.
Publicado 2009

A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ

por Yamanaka, Kinrin, Dorjsuren, Dorjbal, Eoff, Robert L., Egli, Martin, Maloney, David J., Jadhav, Ajit, Simeonov, Anton, Lloyd, R. Stephen
Publicado 2012

Biochemical Analysis of Six Genetic Variants of Error-Prone Human DNA Polymerase ι Involved in Translesion DNA Synthesis

por Kim, Jinsook, Song, Insil, Jo, Ara, Shin, Joo-Ho, Cho, Hana, Eoff, Robert L., Guengerich, F. Peter, Choi, Jeong-Yun
Publicado 2014

Mechanism of Nucleic Acid Unwinding by SARS-CoV Helicase

por Adedeji, Adeyemi O., Marchand, Bruno, te Velthuis, Aartjan J. W., Snijder, Eric J., Weiss, Susan, Eoff, Robert L., Singh, Kamalendra, Sarafianos, Stefan G.
Publicado 2012

Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells

por Reed, Megan R, Maddukuri, Leena, Ketkar, Amit, Byrum, Stephanie D, Zafar, Maroof K, Bostian, April C L, Tackett, Alan J, Eoff, Robert L
Publicado 2021

Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis

por Ketkar, Amit, Sewilam, Reham S., McCrury, Mason J., Hall, Jaycelyn S., Bell, Ashtyn, Paxton, Bethany C., Tripathi, Shreyam, Gunderson, Julie E.C., Eoff, Robert L.
Publicado 2023

323 Generation of a functional precision medicine pipeline which combines comparative transcriptomics and tumor organoid modeling to identify bespoke treatment strategies for gliob...

por Reed, Megan R., Lyle, A. Geoffrey, De Loose, Annick, Learned, Katrina, Vibat, Cecile Rose T., Wardell, Christopher P., Eoff, Robert L., Vaske, Olena M., Rodriguez, Analiz
Publicado 2022

Biobanked Glioblastoma Patient-Derived Organoids as a Precision Medicine Model to Study Inhibition of Invasion

por Darrigues, Emilie, Zhao, Edward H., De Loose, Annick, Lee, Madison P., Borrelli, Michael J., Eoff, Robert L., Galileo, Deni S., Penthala, Narsimha R., Crooks, Peter A., Rodriguez, Analiz
Publicado 2021

Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs

por Ketkar, Amit, Smith, Lane, Johnson, Callie, Richey, Alyssa, Berry, Makayla, Hartman, Jessica H, Maddukuri, Leena, Reed, Megan R, Gunderson, Julie E C, Leung, Justin W C, Eoff, Robert L
Publicado 2021

Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer

por Urbaniak, Alicja, Reed, Megan R., Heflin, Billie, Gaydos, John, Piña-Oviedo, Sergio, Jędrzejczyk, Marta, Klejborowska, Greta, Stępczyńska, Natalia, Chambers, Timothy C., Tackett, Alan J., Rodriguez, Analiz, Huczyński, Adam, Eoff, Robert L., MacNicol, Angus M.
Publicado 2022

A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma

por Reed, Megan R., Lyle, A. Geoffrey, De Loose, Annick, Maddukuri, Leena, Learned, Katrina, Beale, Holly C., Kephart, Ellen T., Cheney, Allison, van den Bout, Anouk, Lee, Madison P., Hundley, Kelsey N., Smith, Ashley M., DesRochers, Teresa M., Vibat, Cecile Rose T., Gokden, Murat, Salama, Sofie, Wardell, Christopher P., Eoff, Robert L., Vaske, Olena M., Rodriguez, Analiz
Publicado 2021