Pathophysiological Investigation of Skeletal Deformities of Musculocontractural Ehlers–Danlos Syndrome Using Induced Pluripotent Stem Cells

por Yue, Fengming, Era, Takumi, Yamaguchi, Tomomi, Kosho, Tomoki
Publicado 2023

Mesenchymal stem cells derived from human iPS cells via mesoderm and neuroepithelium have different features and therapeutic potentials

por Eto, Shinya, Goto, Mizuki, Soga, Minami, Kaneko, Yumi, Uehara, Yusuke, Mizuta, Hiroshi, Era, Takumi
Publicado 2018

A Skeletal Muscle Model of Infantile-onset Pompe Disease with Patient-specific iPS Cells

por Yoshida, Takeshi, Awaya, Tomonari, Jonouchi, Tatsuya, Kimura, Ryo, Kimura, Shigemi, Era, Takumi, Heike, Toshio, Sakurai, Hidetoshi
Publicado 2017

Activin Is Superior to BMP7 for Efficient Maintenance of Human iPSC-Derived Nephron Progenitors

por Tanigawa, Shunsuke, Naganuma, Hidekazu, Kaku, Yusuke, Era, Takumi, Sakuma, Tetsushi, Yamamoto, Takashi, Taguchi, Atsuhiro, Nishinakamura, Ryuichi
Publicado 2019

Taurine rescues mitochondria-related metabolic impairments in the patient-derived induced pluripotent stem cells and epithelial-mesenchymal transition in the retinal pigment epithe...

por Homma, Kohei, Toda, Eriko, Osada, Hideto, Nagai, Norihiro, Era, Takumi, Tsubota, Kazuo, Okano, Hideyuki, Ozawa, Yoko
Publicado 2021

Disease modeling and lentiviral gene transfer in patient-specific induced pluripotent stem cells from late-onset Pompe disease patient

por Sato, Yohei, Kobayashi, Hiroshi, Higuchi, Takashi, Shimada, Yohta, Era, Takumi, Kimura, Shigemi, Eto, Yoshikatsu, Ida, Hiroyuki, Ohashi, Toya
Publicado 2015

Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes

por Kondo, Takayuki, Funayama, Misato, Miyake, Michiyo, Tsukita, Kayoko, Era, Takumi, Osaka, Hitoshi, Ayaki, Takashi, Takahashi, Ryosuke, Inoue, Haruhisa
Publicado 2016

Erratum to: Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes

por Kondo, Takayuki, Funayama, Misato, Miyake, Michiyo, Tsukita, Kayoko, Era, Takumi, Osaka, Hitoshi, Ayaki, Takashi, Takahashi, Ryosuke, Inoue, Haruhisa
Publicado 2016

Synthesis of multi-lactose-appended β-cyclodextrin and its cholesterol-lowering effects in Niemann–Pick type C disease-like HepG2 cells

por Motoyama, Keiichi, Nishiyama, Rena, Maeda, Yuki, Higashi, Taishi, Ishitsuka, Yoichi, Kondo, Yuki, Irie, Tetsumi, Era, Takumi, Arima, Hidetoshi
Publicado 2017

Novel Drug Candidates Improve Ganglioside Accumulation and Neural Dysfunction in GM1 Gangliosidosis Models with Autophagy Activation

por Kajihara, Ryutaro, Numakawa, Tadahiro, Odaka, Haruki, Yaginuma, Yuji, Fusaki, Noemi, Okumiya, Toshika, Furuya, Hirokazu, Inui, Seiji, Era, Takumi
Publicado 2020

A neuropathological cell model derived from Niemann−Pick disease type C patient-specific iPSCs shows disruption of the p62/SQSTM1−KEAP1−NRF2 Axis and impaired formation of neuronal...

por Saito, Ryo, Miyajima, Takashi, Iwamoto, Takeo, Wu, Chen, Suzuki, Ken, Hossain, Mohammad Arif, Munakata, Miyo, Era, Takumi, Eto, Yoshikatsu
Publicado 2021

Cholesterol lowering effects of mono-lactose-appended β-cyclodextrin in Niemann–Pick type C disease-like HepG2 cells

por Motoyama, Keiichi, Hirai, Yumi, Nishiyama, Rena, Maeda, Yuki, Higashi, Taishi, Ishitsuka, Yoichi, Kondo, Yuki, Irie, Tetsumi, Era, Takumi, Arima, Hidetoshi
Publicado 2015

Cellular Functions and Gene and Protein Expression Profiles in Endothelial Cells Derived from Moyamoya Disease-Specific iPS Cells

por Hamauchi, Shuji, Shichinohe, Hideo, Uchino, Haruto, Yamaguchi, Shigeru, Nakayama, Naoki, Kazumata, Ken, Osanai, Toshiya, Abumiya, Takeo, Houkin, Kiyohiro, Era, Takumi
Publicado 2016

Impaired NEPHRIN localization in kidney organoids derived from nephrotic patient iPS cells

por Ohmori, Tomoko, De, Shankhajit, Tanigawa, Shunsuke, Miike, Koichiro, Islam, Mazharul, Soga, Minami, Era, Takumi, Shiona, Shinichi, Nakanishi, Koichi, Nakazato, Hitoshi, Nishinakamura, Ryuichi
Publicado 2021

Rapid repair of human disease-specific single-nucleotide variants by One-SHOT genome editing

por Yokouchi, Yuji, Suzuki, Shinichi, Ohtsuki, Noriko, Yamamoto, Kei, Noguchi, Satomi, Soejima, Yumi, Goto, Mizuki, Ishioka, Ken, Nakamura, Izumi, Suzuki, Satoru, Takenoshita, Seiichi, Era, Takumi
Publicado 2020

Vulnerability to shear stress caused by altered peri-endothelial matrix is a key feature of Moyamoya disease

por Matsuo, Muneaki, Nadanaka, Satomi, Soga, Minami, Sugiyama, Taku, Serigano, Shota, Shimano, Kenjiro, Ichinose, Fumio, Nakamura, Takuji, Maeda, Toshiyuki, Houkin, Kiyohiro, Era, Takumi, Kitagawa, Hiroshi
Publicado 2021

New Type of Sendai Virus Vector Provides Transgene-Free iPS Cells Derived from Chimpanzee Blood

por Fujie, Yasumitsu, Fusaki, Noemi, Katayama, Tomohiko, Hamasaki, Makoto, Soejima, Yumi, Soga, Minami, Ban, Hiroshi, Hasegawa, Mamoru, Yamashita, Satoshi, Kimura, Shigemi, Suzuki, Saori, Matsuzawa, Tetsuro, Akari, Hirofumi, Era, Takumi
Publicado 2014

Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes

por Tanigawa, Shunsuke, Islam, Mazharul, Sharmin, Sazia, Naganuma, Hidekazu, Yoshimura, Yasuhiro, Haque, Fahim, Era, Takumi, Nakazato, Hitoshi, Nakanishi, Koichi, Sakuma, Tetsushi, Yamamoto, Takashi, Kurihara, Hidetake, Taguchi, Atsuhiro, Nishinakamura, Ryuichi
Publicado 2018

In vivo Efficacy and Safety Evaluation of Lactosyl-β-cyclodextrin as a Therapeutic Agent for Hepatomegaly in Niemann-Pick Type C Disease

por Maeda, Yuki, Motoyama, Keiichi, Nishiyama, Rena, Higashi, Taishi, Onodera, Risako, Nakamura, Hideaki, Takeo, Toru, Nakagata, Naomi, Yamada, Yusei, Ishitsuka, Yoichi, Kondo, Yuki, Irie, Tetsumi, Era, Takumi, Arima, Hidetoshi
Publicado 2019

Ectopic Cerebellar Cell Migration Causes Maldevelopment of Purkinje Cells and Abnormal Motor Behaviour in Cxcr4 Null Mice

por Huang, Guo-Jen, Edwards, Andrew, Tsai, Cheng-Yu, Lee, Yi-Shin, Peng, Lei, Era, Takumi, Hirabayashi, Yoshio, Tsai, Ching-Yen, Nishikawa, Shin-Ichi, Iwakura, Yoichiro, Chen, Shu-Jen, Flint, Jonathan
Publicado 2014