The role of lipids in the pathogenesis and treatment of type 2 diabetes and associated co-morbidities

por Erion, Derek M., Park, Hyun-Jun, Lee, Hui-Young
Publicado 2016

Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis

por Matsumoto, Mitsuharu, Yashiro, Hiroaki, Ogino, Hitomi, Aoyama, Kazunobu, Nambu, Tadahiro, Nakamura, Sayuri, Nishida, Mayumi, Wang, Xiaolun, Erion, Derek M., Kaneko, Manami
Publicado 2020

Abrogating Monoacylglycerol Acyltransferase Activity in Liver Improves Glucose Tolerance and Hepatic Insulin Signaling in Obese Mice

por Hall, Angela M., Soufi, Nisreen, Chambers, Kari T., Chen, Zhouji, Schweitzer, George G., McCommis, Kyle S., Erion, Derek M., Graham, Mark J., Su, Xiong, Finck, Brian N.
Publicado 2014

Genome-wide CRISPR Screening to Identify Drivers of TGF-β-Induced Liver Fibrosis in Human Hepatic Stellate Cells

por Yu, Shan, Ericson, Matthew, Fanjul, Andrea, Erion, Derek M., Paraskevopoulou, Maria, Smith, Erin N., Cole, Banumathi, Feaver, Ryan, Holub, Corine, Gavva, Narender, Horman, Shane R., Huang, Jie
Publicado 2022

FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance

por Bernardo, Barbara, Lu, Min, Bandyopadhyay, Gautam, Li, Pingping, Zhou, Yingjiang, Huang, Jie, Levin, Nancy, Tomas, Eva M., Calle, Roberto A., Erion, Derek M., Rolph, Timothy P., Brenner, Martin, Talukdar, Saswata
Publicado 2015

FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasi...

por Mottillo, Emilio P., Desjardins, Eric M., Fritzen, Andreas M., Zou, Vito Z., Crane, Justin D., Yabut, Julian M., Kiens, Bente, Erion, Derek M., Lanba, Adhiraj, Granneman, James G., Talukdar, Saswata, Steinberg, Gregory R.
Publicado 2017

Adipocyte OGT governs diet-induced hyperphagia and obesity

por Li, Min-Dian, Vera, Nicholas B., Yang, Yunfan, Zhang, Bichen, Ni, Weiming, Ziso-Qejvanaj, Enida, Ding, Sheng, Zhang, Kaisi, Yin, Ruonan, Wang, Simeng, Zhou, Xu, Fang, Ethan X., Xu, Tian, Erion, Derek M., Yang, Xiaoyong
Publicado 2018

SirT1 Regulates Adipose Tissue Inflammation

por Gillum, Matthew P., Kotas, Maya E., Erion, Derek M., Kursawe, Romy, Chatterjee, Paula, Nead, Kevin T., Muise, Eric S., Hsiao, Jennifer J., Frederick, David W., Yonemitsu, Shin, Banks, Alexander S., Qiang, Li, Bhanot, Sanjay, Olefsky, Jerrold M., Sears, Dorothy D., Caprio, Sonia, Shulman, Gerald I.
Publicado 2011

The Mammalian INDY Homolog Is Induced by CREB in a Rat Model of Type 2 Diabetes

por Neuschäfer-Rube, Frank, Lieske, Stefanie, Kuna, Manuela, Henkel, Janin, Perry, Rachel J., Erion, Derek M., Pesta, Dominik, Willmes, Diana M., Brachs, Sebastian, von Loeffelholz, Christian, Tolkachov, Alexander, Schupp, Michael, Pathe-Neuschäfer-Rube, Andrea, Pfeiffer, Andreas F.H., Shulman, Gerald I., Püschel, Gerhard P., Birkenfeld, Andreas L.
Publicado 2014

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

por Madiraju, Anila K., Erion, Derek M., Rahimi, Yasmeen, Zhang, Xian-Man, Braddock, Demetrios, Albright, Ronald A., Prigaro, Brett J., Wood, John L., Bhanot, Sanjay, MacDonald, Michael J., Jurczak, Michael, Camporez, Joao-Paulo, Lee, Hui-Young, Cline, Gary W., Samuel, Varman T., Kibbey, Richard G., Shulman, Gerald I.
Publicado 2014

Role of Patatin-Like Phospholipase Domain-Containing 3 on Lipid-Induced Hepatic Steatosis and Insulin Resistance in Rats

por Kumashiro, Naoki, Yoshimura, Toru, Cantley, Jennifer L, Majumdar, Sachin K, Guebre-Egziabher, Fitsum, Kursawe, Romy, Vatner, Daniel F, Fat, Ioana, Kahn, Mario, Erion, Derek M, Zhang, Xian-Man, Zhang, Dongyan, Manchem, Vara Prasad, Bhanot, Sanjay, Gerhard, Glenn S, Petersen, Kitt F, Cline, Gary W, Samuel, Varman T, Shulman, Gerald I
Publicado 2013

Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis

por Shepherd, Emma L., Saborano, Raquel, Northall, Ellie, Matsuda, Kae, Ogino, Hitomi, Yashiro, Hiroaki, Pickens, Jason, Feaver, Ryan E., Cole, Banumathi K., Hoang, Stephen A., Lawson, Mark J., Olson, Matthew, Figler, Robert A., Reardon, John E., Nishigaki, Nobuhiro, Wamhoff, Brian R., Günther, Ulrich L., Hirschfield, Gideon, Erion, Derek M., Lalor, Patricia F.
Publicado 2020

The Hepatoselective Glucokinase Activator PF-04991532 Ameliorates Hyperglycemia without Causing Hepatic Steatosis in Diabetic Rats

por Erion, Derek M., Lapworth, Amanda, Amor, Paul A., Bai, Guoyun, Vera, Nicholas B., Clark, Ronald W., Yan, Qingyun, Zhu, Yimin, Ross, Trenton T., Purkal, Julie, Gorgoglione, Matthew, Zhang, Guodong, Bonato, Vinicius, Baker, Levenia, Barucci, Nicole, D’Aquila, Theresa, Robertson, Alan, Aiello, Robert J., Yan, Jiangli, Trimmer, Jeff, Rolph, Timothy P., Pfefferkorn, Jeffrey A.
Publicado 2014

Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction

por Gutierrez, Jemy A., Liu, Wei, Perez, Sylvie, Xing, Gang, Sonnenberg, Gabriele, Kou, Kou, Blatnik, Matt, Allen, Richard, Weng, Yan, Vera, Nicholas B., Chidsey, Kristin, Bergman, Arthur, Somayaji, Veena, Crowley, Collin, Clasquin, Michelle F., Nigam, Anu, Fulham, Melissa A., Erion, Derek M., Ross, Trenton T., Esler, William P., Magee, Thomas V., Pfefferkorn, Jeffrey A., Bence, Kendra K., Birnbaum, Morris J., Tesz, Gregory J.
Publicado 2021

Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)

por Huard, Kim, Brown, Janice, Jones, Jessica C., Cabral, Shawn, Futatsugi, Kentaro, Gorgoglione, Matthew, Lanba, Adhiraj, Vera, Nicholas B., Zhu, Yimin, Yan, Qingyun, Zhou, Yingjiang, Vernochet, Cecile, Riccardi, Keith, Wolford, Angela, Pirman, David, Niosi, Mark, Aspnes, Gary, Herr, Michael, Genung, Nathan E., Magee, Thomas V., Uccello, Daniel P., Loria, Paula, Di, Li, Gosset, James R., Hepworth, David, Rolph, Timothy, Pfefferkorn, Jeffrey A., Erion, Derek M.
Publicado 2015