Optimizing the Safety and Efficacy of Bio-Radiopharmaceuticals for Cancer Therapy

por Funeh, Cyprine Neba, Bridoux, Jessica, Ertveldt, Thomas, De Groof, Timo W. M., Chigoho, Dora Mugoli, Asiabi, Parinaz, Covens, Peter, D’Huyvetter, Matthias, Devoogdt, Nick
Publicado 2023

Development and evaluation of nanobody tracers for noninvasive nuclear imaging of the immune-checkpoint TIGIT

por Zeven, Katty, De Groof, Timo W.M., Ceuppens, Hannelore, Awad, Robin Maximilian, Ertveldt, Thomas, de Mey, Wout, Meeus, Fien, Raes, Geert, Breckpot, Karine, Devoogdt, Nick
Publicado 2023

Single-Domain Antibody Nuclear Imaging Allows Noninvasive Quantification of LAG-3 Expression by Tumor-Infiltrating Leukocytes and Predicts Response of Immune Checkpoint Blockade

por Lecocq, Quentin, Awad, Robin Maximilian, De Vlaeminck, Yannick, de Mey, Wout, Ertveldt, Thomas, Goyvaerts, Cleo, Raes, Geert, Thielemans, Kris, Keyaerts, Marleen, Devoogdt, Nick, Breckpot, Karine
Publicado 2021

In vitro modelling of local gene therapy with IL-15/IL-15Rα and a PD-L1 antagonist in melanoma reveals an interplay between NK cells and CD4(+) T cells

por Awad, Robin Maximilian, De Vlaeminck, Yannick, Meeus, Fien, Ertveldt, Thomas, Zeven, Katty, Ceuppens, Hannelore, Goyvaerts, Cleo, Verdonck, Magali, Salguero, Gustavo, Raes, Geert, Devoogdt, Nick, Breckpot, Karine
Publicado 2023

CS1-specific single-domain antibodies labeled with Actinium-225 prolong survival and increase CD8+ T cells and PD-L1 expression in Multiple Myeloma

por De Veirman, Kim, Puttemans, Janik, Krasniqi, Ahmet, Ertveldt, Thomas, Hanssens, Heleen, Romao, Ema, Hose, Dirk, Goyvaert, Cleo, Vlummens, Philip, Muyldermans, Serge, Breckpot, Karine, Bruchertseifer, Frank, Morgenstern, Alfred, D’Huyvetter, Matthias, Devoogdt, Nick
Publicado 2021

Formatting and gene-based delivery of a human PD-L1 single domain antibody for immune checkpoint blockade

por Awad, Robin Maximilian, Lecocq, Quentin, Zeven, Katty, Ertveldt, Thomas, De Beck, Lien, Ceuppens, Hannelore, Broos, Katrijn, De Vlaeminck, Yannick, Goyvaerts, Cleo, Verdonck, Magali, Raes, Geert, Van Parys, Alexander, Cauwels, Anje, Keyaerts, Marleen, Devoogdt, Nick, Breckpot, Karine
Publicado 2021

Targeted Radionuclide Therapy with Low and High-Dose Lutetium-177–Labeled Single Domain Antibodies Induces Distinct Immune Signatures in a Mouse Melanoma Model

por Ertveldt, Thomas, De Beck, Lien, De Ridder, Kirsten, Locy, Hanne, de Mey, Wout, Goyvaerts, Cleo, Lecocq, Quentin, Ceuppens, Hannelore, De Vlaeminck, Yannick, Awad, Robin Maximilian, Keyaerts, Marleen, Devoogdt, Nick, D'Huyvetter, Matthias, Breckpot, Karine, Krasniqi, Ahmet
Publicado 2022

Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8(+) T cell and iNKT cell activating mRNA vaccine

por Ertveldt, Thomas, Meulewaeter, Sofie, De Vlaeminck, Yannick, Olarte, Oscar, Broos, Katrijn, Van Calenbergh, Serge, Bourgeois, Stephanie, Deprez, Joke, Heremans, Yves, Goyvaerts, Cleo, Staels, Willem, De Smedt, Stefaan, Dewitte, Heleen, Devoogdt, Nick, Keyaerts, Marleen, Verbeke, Rein, Barbé, Kurt, Lentacker, Ine, Breckpot, Karine
Publicado 2023

TNF-α-Secreting Lung Tumor-Infiltrated Monocytes Play a Pivotal Role During Anti-PD-L1 Immunotherapy

por De Ridder, Kirsten, Locy, Hanne, Piccioni, Elisa, Zuazo, Miren Ibarra, Awad, Robin Maximilian, Verhulst, Stefaan, Van Bulck, Mathias, De Vlaeminck, Yannick, Lecocq, Quentin, Reijmen, Eva, De Mey, Wout, De Beck, Lien, Ertveldt, Thomas, Pintelon, Isabel, Timmermans, Jean-Pierre, Escors, David, Keyaerts, Marleen, Breckpot, Karine, Goyvaerts, Cleo
Publicado 2022