N–N Bond-Forming Cyclization for the One-Pot Synthesis of N-Aryl[3,4-d]pyrazolopyrimidines

por Evans, Lindsay E., Cheeseman, Matthew D., Jones, Keith
Publicado 2012

Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex

por Evans, Lindsay E., Jones, Keith, Cheeseman, Matthew D.
Publicado 2017

Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition

por Evans, Lindsay E., Cheeseman, Matthew D., Yahya, Norhakim, Jones, Keith
Publicado 2015

Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug

por Evans, Lindsay E., Krishna, Aishwarya, Ma, Yajing, Webb, Thomas E., Marshall, Dominic C., Tooke, Catherine L., Spencer, James, Clarke, Thomas B., Armstrong, Alan, Edwards, Andrew M.
Publicado 2019

Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus()

por Lim, Carine S.Q., Ha, Kam Pou, Clarke, Rebecca S., Gavin, Leigh-Anne, Cook, Declan T., Hutton, Jennie A., Sutherell, Charlotte L., Edwards, Andrew M., Evans, Lindsay E., Tate, Edward W., Lanyon-Hogg, Thomas
Publicado 2019

Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

por Sabnis, Akshay, Hagart, Katheryn LH, Klöckner, Anna, Becce, Michele, Evans, Lindsay E, Furniss, R Christopher D, Mavridou, Despoina AI, Murphy, Ronan, Stevens, Molly M, Davies, Jane C, Larrouy-Maumus, Gérald J, Clarke, Thomas B, Edwards, Andrew M
Publicado 2021

Privileged Structures and Polypharmacology within and between Protein Families

por Meyers, Joshua, Chessum, Nicola E. A., Ali, Salyha, Mok, N. Yi, Wilding, Birgit, Pasqua, A. Elisa, Rowlands, Martin, Tucker, Michael J., Evans, Lindsay E., Rye, Carl S., O’Fee, Lisa, Le Bihan, Yann-Vaï, Burke, Rosemary, Carter, Michael, Workman, Paul, Blagg, Julian, Brown, Nathan, van Montfort, Rob L. M., Jones, Keith, Cheeseman, Matthew D.
Publicado 2018

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies

por Pasqua, A. Elisa, Sharp, Swee Y., Chessum, Nicola E. A., Hayes, Angela, Pellegrino, Loredana, Tucker, Michael J., Miah, Asadh, Wilding, Birgit, Evans, Lindsay E., Rye, Carl S., Mok, N. Yi, Liu, Manjuan, Henley, Alan T., Gowan, Sharon, De Billy, Emmanuel, te Poele, Robert, Powers, Marissa, Eccles, Suzanne A., Clarke, Paul A., Raynaud, Florence I., Workman, Paul, Jones, Keith, Cheeseman, Matthew D.
Publicado 2023

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

por Cheeseman, Matthew D., Chessum, Nicola E. A., Rye, Carl S., Pasqua, A. Elisa, Tucker, Michael J., Wilding, Birgit, Evans, Lindsay E., Lepri, Susan, Richards, Meirion, Sharp, Swee Y., Ali, Salyha, Rowlands, Martin, O’Fee, Lisa, Miah, Asadh, Hayes, Angela, Henley, Alan T., Powers, Marissa, te Poele, Robert, De Billy, Emmanuel, Pellegrino, Loredana, Raynaud, Florence, Burke, Rosemary, van Montfort, Rob L. M., Eccles, Suzanne A., Workman, Paul, Jones, Keith
Publicado 2016