Physiologically‐based pharmacokinetic modeling to evaluate in vitro‐to‐in vivo extrapolation for intestinal P‐glycoprotein inhibition

por Yamazaki, Shinji, Evers, Raymond, De Zwart, Loeckie
Publicado 2021

Corrigendum to: Physiologically‐based pharmacokinetic modeling to evaluate in vitro‐to‐in vivo extrapolation for intestinal P‐glycoprotein inhibition

por Yamazaki, Shinji, Evers, Raymond, De Zwart, Loeckie
Publicado 2022

Physiologically‐based pharmacokinetic modeling for primary metabolites of CYP3A and P‐glycoprotein inhibitors in drug–drug interactions: Should we assume the free drug hypothesis?...

por Yamazaki, Shinji, Evers, Raymond, De Zwart, Loeckie
Publicado 2022

Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes

por Hariparsad, Niresh, Chu, Xiaoyan, Yabut, Jocelyn, Labhart, Paul, Hartley, Dylan P., Dai, Xudong, Evers, Raymond
Publicado 2009

Assessment of Pharmacokinetic Interaction Between Gefapixant (MK‐7264), a P2X3 Receptor Antagonist, and the OATP1B1 Drug Transporter Substrate Pitavastatin

por McCrea, Jacqueline B., Hussain, Azher, Ma, Bennett, Garrett, Graigory C., Evers, Raymond, Laabs, John E., Stoch, S. Aubrey, Iwamoto, Marian
Publicado 2021

Predicting changes in the pharmacokinetics of CYP3A‐metabolized drugs in hepatic impairment and insights into factors driving these changes

por Ladumor, Mayur K., Storelli, Flavia, Liang, Xiaomin, Lai, Yurong, Enogieru, Osatohanmwen J., Chothe, Paresh P., Evers, Raymond, Unadkat, Jashvant D.
Publicado 2022

AAPS Workshop Report: Strategies to Address Therapeutic Protein–Drug Interactions during Clinical Development

por Girish, Sandhya, Martin, Steven W, Peterson, Mark C, Zhang, Lei K., Zhao, Hong, Balthasar, Joseph, Evers, Raymond, Zhou, Honghui, Zhu, Min, Klunk, Lewis, Han, Chao, Berglund, Eva Gil, Huang, Shiew-Mei, Joshi, Amita
Publicado 2011

Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium

por Brouwer, Kim L.R., Evers, Raymond, Hayden, Elizabeth, Hu, Shuiying, Li, Cindy Yanfei, Meyer zu Schwabedissen, Henriette E., Neuhoff, Sibylle, Oswald, Stefan, Piquette‐Miller, Micheline, Saran, Chitra, Sjöstedt, Noora, Sprowl, Jason A., Stahl, Simone H., Yue, Wei
Publicado 2022

Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-...

por Monroe, James J, Tanis, Keith Q, Podtelezhnikov, Alexei A, Nguyen, Truyen, Machotka, Sam V, Lynch, Donna, Evers, Raymond, Palamanda, Jairam, Miller, Randy R, Pippert, Todd, Cabalu, Tamara D, Johnson, Timothy E, Aslamkhan, Amy G, Kang, Wen, Tamburino, Alex M, Mitra, Kaushik, Agrawal, Nancy G B, Sistare, Frank D
Publicado 2020