The Future of Uncertainty Factors With In Vitro Studies Using Human Cells

por Dourson, Michael, Ewart, Lorna, Fitzpatrick, Suzanne C, Barros, Silvia B M, Mahadevan, Brinda, Hayes, A Wallace
Publicado 2021

Optimal experimental design for efficient toxicity testing in microphysiological systems: A bone marrow application

por Cairns, Jonathan, Leonard, Emilyanne, Khan, Kainat, Parks, Conor, Maglennon, Gareth, Zhang, Bairu, Lazic, Stanley E., Ewart, Lorna, David, Rhiannon
Publicado 2023

A peripherally restricted P2Y(12) receptor antagonist altered rat tumor incidences with no human relevance: Mode of action consistent with dopamine agonism

por Brott, David A., Andersson, Håkan A.S., Stewart, Jane, Ewart, Lorna, Christoph, Greg, Harleman, Johannes, Armstrong, Duncan, Kinter, Lewis B.
Publicado 2014

Physiological Replication of the Human Glomerulus Using a Triple Culture Microphysiological System

por Pajoumshariati, Ramin, Ewart, Lorna, Kujala, Ville, Luc, Raymond, Peel, Samantha, Corrigan, Adam, Weber, Heather, Nugraha, Bramasta, Hansen, Pernille B. L., Williams, Julie
Publicado 2023

A microengineered Brain-Chip to model neuroinflammation in humans

por Pediaditakis, Iosif, Kodella, Konstantia R., Manatakis, Dimitris V., Le, Christopher Y., Barthakur, Sonalee, Sorets, Alexander, Gravanis, Achille, Ewart, Lorna, Rubin, Lee L., Manolakos, Elias S., Hinojosa, Christopher D., Karalis, Katia
Publicado 2022

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

por Bauer, Sophie, Wennberg Huldt, Charlotte, Kanebratt, Kajsa P., Durieux, Isabell, Gunne, Daniela, Andersson, Shalini, Ewart, Lorna, Haynes, William G., Maschmeyer, Ilka, Winter, Annika, Ämmälä, Carina, Marx, Uwe, Andersson, Tommy B.
Publicado 2017

Publisher Correction: Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

por Bauer, Sophie, Wennberg Huldt, Charlotte, Kanebratt, Kajsa P., Durieux, Isabell, Gunne, Daniela, Andersson, Shalini, Ewart, Lorna, Haynes, William G., Maschmeyer, Ilka, Winter, Annika, Ämmälä, Carina, Marx, Uwe, Andersson, Tommy B.
Publicado 2018

Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

por Pediaditakis, Iosif, Kodella, Konstantia R., Manatakis, Dimitris V., Le, Christopher Y., Hinojosa, Chris D., Tien-Street, William, Manolakos, Elias S., Vekrellis, Kostas, Hamilton, Geraldine A., Ewart, Lorna, Rubin, Lee L., Karalis, Katia
Publicado 2021

Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system

por Kostrzewski, Tomasz, Snow, Sophie, Battle, Anya Lindström, Peel, Samantha, Ahmad, Zahida, Basak, Jayati, Surakala, Manasa, Bornot, Aurelie, Lindgren, Julia, Ryaboshapkina, Maria, Clausen, Maryam, Lindén, Daniel, Maass, Christian, Young, Lucy May, Corrigan, Adam, Ewart, Lorna, Hughes, David
Publicado 2021

A Novel Microphysiological Colon Platform to Decipher Mechanisms Driving Human Intestinal Permeability

por Apostolou, Athanasia, Panchakshari, Rohit A., Banerjee, Antara, Manatakis, Dimitris V., Paraskevopoulou, Maria D., Luc, Raymond, Abu-Ali, Galeb, Dimitriou, Alexandra, Lucchesi, Carolina, Kulkarni, Gauri, Maulana, Tengku Ibrahim, Kasendra, Magdalena, Kerns, Jordan S., Bleck, Bertram, Ewart, Lorna, Manolakos, Elias S., Hamilton, Geraldine A., Giallourakis, Cosmas, Karalis, Katia
Publicado 2021

On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships

por McAleer, Christopher W., Pointon, Amy, Long, Christopher J., Brighton, Rocky L., Wilkin, Benjamin D., Bridges, L. Richard, Narasimhan Sriram, Narasimham, Fabre, Kristin, McDougall, Robin, Muse, Victorine P., Mettetal, Jerome T., Srivastava, Abhishek, Williams, Dominic, Schnepper, Mark T., Roles, Jeff L., Shuler, Michael L., Hickman, James J., Ewart, Lorna
Publicado 2019

3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration

por Wang, Hongbing, Brown, Paul C., Chow, Edwin C.Y., Ewart, Lorna, Ferguson, Stephen S., Fitzpatrick, Suzanne, Freedman, Benjamin S., Guo, Grace L., Hedrich, William, Heyward, Scott, Hickman, James, Isoherranen, Nina, Li, Albert P., Liu, Qi, Mumenthaler, Shannon M., Polli, James, Proctor, William R., Ribeiro, Alexandre, Wang, Jian‐Ying, Wange, Ronald L., Huang, Shiew‐Mei
Publicado 2021

On-chip recapitulation of clinical bone-marrow toxicities and patient-specific pathophysiology

por Chou, David B., Frismantas, Viktoras, Milton, Yuka, David, Rhiannon, Pop-Damkov, Petar, Ferguson, Douglas, MacDonald, Alexander, Bölükbaşı, Özge Vargel, Joyce, Cailin E., Teixeira, Liliana S. Moreira, Rech, Arianna, Jiang, Amanda, Calamari, Elizabeth, Jalili-Firoozinezhad, Sasan, Furlong, Brooke A., O’Sullivan, Lucy R., Ng, Carlos F., Choe, Youngjae, Clauson, Susan, Myers, Kasiani C., Weinberg, Olga K., Hasserjian, Robert P., Novak, Richard, Levy, Oren, Prantil-Baun, Rachelle, Novina, Carl D., Shimamura, Akiko, Ewart, Lorna, Ingber, Donald E.
Publicado 2020

Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology

por Ewart, Lorna, Apostolou, Athanasia, Briggs, Skyler A., Carman, Christopher V., Chaff, Jake T., Heng, Anthony R., Jadalannagari, Sushma, Janardhanan, Jeshina, Jang, Kyung-Jin, Joshipura, Sannidhi R., Kadam, Mahika M., Kanellias, Marianne, Kujala, Ville J., Kulkarni, Gauri, Le, Christopher Y., Lucchesi, Carolina, Manatakis, Dimitris V., Maniar, Kairav K., Quinn, Meaghan E., Ravan, Joseph S., Rizos, Ann Catherine, Sauld, John F. K., Sliz, Josiah D., Tien-Street, William, Trinidad, Dennis Ramos, Velez, James, Wendell, Max, Irrechukwu, Onyi, Mahalingaiah, Prathap Kumar, Ingber, Donald E., Scannell, Jack W., Levner, Daniel
Publicado 2022

Author Correction: Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology

por Ewart, Lorna, Apostolou, Athanasia, Briggs, Skyler A., Carman, Christopher V., Chaff, Jake T., Heng, Anthony R., Jadalannagari, Sushma, Janardhanan, Jeshina, Jang, Kyung-Jin, Joshipura, Sannidhi R., Kadam, Mahika M., Kanellias, Marianne, Kujala, Ville J., Kulkarni, Gauri, Le, Christopher Y., Lucchesi, Carolina, Manatakis, Dimitris V., Maniar, Kairav K., Quinn, Meaghan E., Ravan, Joseph S., Rizos, Ann Catherine, Sauld, John F. K., Sliz, Josiah D., Tien-Street, William, Trinidad, Dennis Ramos, Velez, James, Wendell, Max, Irrechukwu, Onyi, Mahalingaiah, Prathap Kumar, Ingber, Donald E., Scannell, Jack W., Levner, Daniel
Publicado 2023

Author Correction: Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology

por Ewart, Lorna, Apostolou, Athanasia, Briggs, Skyler A., Carman, Christopher V., Chaff, Jake T., Heng, Anthony R., Jadalannagari, Sushma, Janardhanan, Jeshina, Jang, Kyung-Jin, Joshipura, Sannidhi R., Kadam, Mahika M., Kanellias, Marianne, Kujala, Ville J., Kulkarni, Gauri, Le, Christopher Y., Lucchesi, Carolina, Manatakis, Dimitris V., Maniar, Kairav K., Quinn, Meaghan E., Ravan, Joseph S., Rizos, Ann Catherine, Sauld, John F. K., Sliz, Josiah D., Tien-Street, William, Trinidad, Dennis Ramos, Velez, James, Wendell, Max, Irrechukwu, Onyi, Mahalingaiah, Prathap Kumar, Ingber, Donald E., Scannell, Jack W., Levner, Daniel
Publicado 2023

Biology-Inspired Microphysiological Systems to Advance Patient Benefit and Animal Welfare in Drug Development

por Marx, Uwe, Akabane, Takafumi, Andersson, Tommy B., Baker, Elizabeth, Beilmann, Mario, Beken, Sonja, Brendler-Schwaab, Susanne, Cirit, Murat, David, Rhiannon, Dehne, Eva-Maria, Durieux, Isabell, Ewart, Lorna, Fitzpatrick, Suzanne C., Frey, Olivier, Fuchs, Florian, Griffith, Linda G., Hamilton, Geraldine A., Hartung, Thomas, Hoeng, Julia, Hogberg, Helena, Hughes, David J., Ingber, Donald E., Iskandar, Anita, Kanamori, Toshiyuki, Kojima, Hajime, Kuehnl, Jochen, Leist, Marcel, Li, Bo, Loskill, Peter, Mendrick, Donna L., Neumann, Thomas, Pallocca, Giorgia, Rusyn, Ivan, Smirnova, Lena, Steger-Hartmann, Thomas, Tagle, Danilo A., Tonevitsky, Alexander, Tsyb, Sergej, Trapecar, Martin, van de Water, Bob, van den Eijnden-van Raaij, Janny, Vulto, Paul, Watanabe, Kengo, Wolf, Armin, Zhou, Xiaobing, Roth, Adrian
Publicado 2020