Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design

por Fiorillo, Annarita, Colotti, Gianni, Exertier, Cécile, Liuzzi, Anastasia, Seghetti, Francesca, Salerno, Alessandra, Caciolla, Jessica, Ilari, Andrea
Publicado 2022

Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating

por Exertier, Cécile, Milazzo, Lisa, Freda, Ida, Montemiglio, Linda Celeste, Scaglione, Antonella, Cerutti, Gabriele, Parisi, Giacomo, Anselmi, Massimiliano, Smulevich, Giulietta, Savino, Carmelinda, Vallone, Beatrice
Publicado 2019

ALS2-Related Motor Neuron Diseases: From Symptoms to Molecules

por Miceli, Marcello, Exertier, Cécile, Cavaglià, Marco, Gugole, Elena, Boccardo, Marta, Casaluci, Rossana Rita, Ceccarelli, Noemi, De Maio, Alessandra, Vallone, Beatrice, Deriu, Marco A.
Publicado 2022

Dissecting the Cytochrome P450 OleP Substrate Specificity: Evidence for a Preferential Substrate

por Parisi, Giacomo, Freda, Ida, Exertier, Cécile, Cecchetti, Cristina, Gugole, Elena, Cerutti, Gabriele, D’Auria, Lucia, Macone, Alberto, Vallone, Beatrice, Savino, Carmelinda, Montemiglio, Linda Celeste
Publicado 2020

The Nuts and Bolts of SARS-CoV-2 Spike Receptor-Binding Domain Heterologous Expression

por Maffei, Mariano, Montemiglio, Linda Celeste, Vitagliano, Grazia, Fedele, Luigi, Sellathurai, Shaila, Bucci, Federica, Compagnone, Mirco, Chiarini, Valerio, Exertier, Cécile, Muzi, Alessia, Roscilli, Giuseppe, Vallone, Beatrice, Marra, Emanuele
Publicado 2021

Inhibition of Leishmania infantum Trypanothione Reductase by New Aminopropanone Derivatives Interacting with the NADPH Binding Site

por Madia, Valentina Noemi, Ialongo, Davide, Patacchini, Elisa, Exertier, Cécile, Antonelli, Lorenzo, Colotti, Gianni, Messore, Antonella, Tudino, Valeria, Saccoliti, Francesco, Scipione, Luigi, Ilari, Andrea, Costi, Roberta, Di Santo, Roberto
Publicado 2023

Point Mutations at a Key Site Alter the Cytochrome P450 OleP Structural Dynamics

por Montemiglio, Linda Celeste, Gugole, Elena, Freda, Ida, Exertier, Cécile, D’Auria, Lucia, Chen, Cheng Giuseppe, Nardi, Alessandro Nicola, Cerutti, Gabriele, Parisi, Giacomo, D’Abramo, Marco, Savino, Carmelinda, Vallone, Beatrice
Publicado 2021

Effect of Salts on the Conformational Dynamics of the Cytochrome P450 OleP

por De Sciscio, Maria Laura, Nardi, Alessandro Nicola, Parisi, Giacomo, Bulfaro, Giovanni, Costanzo, Antonella, Gugole, Elena, Exertier, Cécile, Freda, Ida, Savino, Carmelinda, Vallone, Beatrice, Montemiglio, Linda Celeste, D’Abramo, Marco
Publicado 2023

Crystal structure and functional characterization of an oligosaccharide dehydrogenase from Pycnoporus cinnabarinus provides insights into fungal breakdown of lignocellulose

por Cerutti, Gabriele, Gugole, Elena, Montemiglio, Linda Celeste, Turbé-Doan, Annick, Chena, Dehbia, Navarro, David, Lomascolo, Anne, Piumi, François, Exertier, Cécile, Freda, Ida, Vallone, Beatrice, Record, Eric, Savino, Carmelinda, Sciara, Giuliano
Publicado 2021

Probing the Role of Murine Neuroglobin CDloop–D-Helix Unit in CO Ligand Binding and Structural Dynamics

por Exertier, Cécile, Sebastiani, Federico, Freda, Ida, Gugole, Elena, Cerutti, Gabriele, Parisi, Giacomo, Montemiglio, Linda Celeste, Becucci, Maurizio, Viappiani, Cristiano, Bruno, Stefano, Savino, Carmelinda, Zamparelli, Carlotta, Anselmi, Massimiliano, Abbruzzetti, Stefania, Smulevich, Giulietta, Vallone, Beatrice
Publicado 2022

Ligand pathways in neuroglobin revealed by low-temperature photodissociation and docking experiments

por Ardiccioni, Chiara, Arcovito, Alessandro, Della Longa, Stefano, van der Linden, Peter, Bourgeois, Dominique, Weik, Martin, Montemiglio, Linda Celeste, Savino, Carmelinda, Avella, Giovanna, Exertier, Cécile, Carpentier, Philippe, Prangé, Thierry, Brunori, Maurizio, Colloc’h, Nathalie, Vallone, Beatrice
Publicado 2019

Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR

por Freda, Ida, Exertier, Cécile, Barile, Anna, Chaves-Sanjuan, Antonio, Vega, Mirella Vivoli, Isupov, Michail N, Harmer, Nicholas J, Gugole, Elena, Swuec, Paolo, Bolognesi, Martino, Scipioni, Anita, Savino, Carmelinda, Di Salvo, Martino Luigi, Contestabile, Roberto, Vallone, Beatrice, Tramonti, Angela, Montemiglio, Linda Celeste
Publicado 2023