Negative regulation by nuclear receptors: a plethora of mechanisms

por Santos, Guilherme M., Fairall, Louise, Schwabe, John W.R.
Publicado 2011

Nuclear hormone receptor co-repressors: Structure and function

por Watson, Peter J., Fairall, Louise, Schwabe, John W.R.
Publicado 2012

Towards an understanding of the structure and function of MTA1

por Millard, Christopher J., Fairall, Louise, Schwabe, John W. R.
Publicado 2014

Structure of HDAC3 bound to corepressor and inositol tetraphosphate

por Watson, Peter J., Fairall, Louise, Santos, Guilherme M., Schwabe, John W.R.
Publicado 2012

Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex

por Hudson, Gregg M., Watson, Peter J., Fairall, Louise, Jamieson, Andrew G., Schwabe, John W. R.
Publicado 2015

The topology of chromatin-binding domains in the NuRD deacetylase complex

por Millard, Christopher J, Fairall, Louise, Ragan, Timothy J, Savva, Christos G, Schwabe, John W R
Publicado 2020

A potential histone-chaperone activity for the MIER1 histone deacetylase complex

por Wang, Siyu, Fairall, Louise, Pham, Trong Khoa, Ragan, Timothy J, Vashi, Dipti, Collins, Mark O, Dominguez, Cyril, Schwabe, John W R
Publicado 2023

Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates

por Millard, Christopher J., Watson, Peter J., Celardo, Ivana, Gordiyenko, Yuliya, Cowley, Shaun M., Robinson, Carol V., Fairall, Louise, Schwabe, John W.R.
Publicado 2013

The Ansamycin Antibiotic, Rifamycin SV, Inhibits BCL6 Transcriptional Repression and Forms a Complex with the BCL6-BTB/POZ Domain

por Evans, Sian E., Goult, Benjamin T., Fairall, Louise, Jamieson, Andrew G., Ko Ferrigno, Paul, Ford, Robert, Schwabe, John W. R., Wagner, Simon D.
Publicado 2014

Recombinant Protein Expression for Structural Biology in HEK 293F Suspension Cells: A Novel and Accessible Approach

por Portolano, Nicola, Watson, Peter J., Fairall, Louise, Millard, Christopher J., Milano, Charles P., Song, Yun, Cowley, Shaun M., Schwabe, John W.R.
Publicado 2014

The structure of the core NuRD repression complex provides insights into its interaction with chromatin

por Millard, Christopher J, Varma, Niranjan, Saleh, Almutasem, Morris, Kyle, Watson, Peter J, Bottrill, Andrew R, Fairall, Louise, Smith, Corinne J, Schwabe, John WR
Publicado 2016

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

por Dickens, Laura S., Boyd, Robert S., Jukes-Jones, Rebekah, Hughes, Michelle A., Robinson, Gemma L., Fairall, Louise, Schwabe, John W.R., Cain, Kelvin, MacFarlane, Marion
Publicado 2012

Diverse nucleosome Site-Selectivity among histone deacetylase complexes

por Wang, Zhipeng A, Millard, Christopher J, Lin, Chia-Liang, Gurnett, Jennifer E, Wu, Mingxuan, Lee, Kwangwoon, Fairall, Louise, Schwabe, John WR, Cole, Philip A
Publicado 2020

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

por Hughes, Michelle A., Powley, Ian R., Jukes-Jones, Rebekah, Horn, Sebastian, Feoktistova, Maria, Fairall, Louise, Schwabe, John W.R., Leverkus, Martin, Cain, Kelvin, MacFarlane, Marion
Publicado 2016

Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor α1 Mutant Proteins

por Moran, Carla, Agostini, Maura, McGowan, Anne, Schoenmakers, Erik, Fairall, Louise, Lyons, Greta, Rajanayagam, Odelia, Watson, Laura, Offiah, Amaka, Barton, John, Price, Susan, Schwabe, John, Chatterjee, Krishna
Publicado 2017

Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting

por Itoh, Toshimasa, Fairall, Louise, Muskett, Frederick W., Milano, Charles P., Watson, Peter J., Arnaudo, Nadia, Saleh, Almutasem, Millard, Christopher J., El-Mezgueldi, Mohammed, Martino, Fabrizio, Schwabe, John W.R.
Publicado 2015

Hyperthyroxinemia and Hypercortisolemia due to Familial Dysalbuminemia

por Moran, Carla, Seger, Christoph, Taylor, Kevin, Oddy, Susan, Burling, Keith, Rajanayagam, Odelia, Fairall, Louise, McGowan, Anne, Lyons, Greta, Halsall, David, Gurnell, Mark, Schwabe, John, Chatterjee, Krishna, Strey, Christopher
Publicado 2020

Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate

por Fox, Joanna L., Hughes, Michelle A., Meng, Xin, Sarnowska, Nikola A., Powley, Ian R., Jukes-Jones, Rebekah, Dinsdale, David, Ragan, Timothy J., Fairall, Louise, Schwabe, John W. R., Morone, Nobuhiro, Cain, Kelvin, MacFarlane, Marion
Publicado 2021

Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex

por Song, Yun, Dagil, Lisbeth, Fairall, Louise, Robertson, Naomi, Wu, Mingxuan, Ragan, T.J., Savva, Christos G., Saleh, Almutasem, Morone, Nobuhiro, Kunze, Micha B.A., Jamieson, Andrew G., Cole, Philip A., Hansen, D. Flemming, Schwabe, John W.R.
Publicado 2020

Structure-Guided Approach to Relieving Transcriptional Repression in Resistance to Thyroid Hormone α

por Romartinez-Alonso, Beatriz, Agostini, Maura, Jones, Heulyn, McLellan, Jayde, Sood, D. Eilidh, Tomkinson, Nicholas, Marelli, Federica, Gentile, Ilaria, Visser, W. Edward, Schoenmakers, Erik, Fairall, Louise, Privalsky, Martin, Moran, Carla, Persani, Luca, Chatterjee, Krishna, Schwabe, John W. R.
Publicado 2022