Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease

por Tumbale, Percy, Schellenberg, Matthew J, Mueller, Geoffrey A, Fairweather, Emma, Watson, Mandy, Little, Jessica N, Krahn, Juno, Waddell, Ian, London, Robert E, Williams, R Scott
Publicado 2018

An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells

por James, Dominic I., Durant, Stephen, Eckersley, Kay, Fairweather, Emma, Griffiths, Louise A., Hamilton, Nicola, Kelly, Paul, O'Connor, Mark, Shea, Kerry, Waddell, Ian D., Ogilvie, Donald J.
Publicado 2016

Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases

por Venkat, Aarya, Watterson, Grace, Byrne, Dominic P., O’Boyle, Brady, Shrestha, Safal, Gravel, Nathan, Fairweather, Emma E., Daly, Leonard A., Bunn, Claire, Yeung, Wayland, Aggarwal, Ishan, Katiyar, Samiksha, Eyers, Claire E., Eyers, Patrick A., Kannan, Natarajan
Publicado 2023

Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases

por Venkat, Aarya, Watterson, Grace, Byrne, Dominic P, O'Boyle, Brady, Shrestha, Safal, Gravel, Nathan, Fairweather, Emma E, Daly, Leonard A, Bunn, Claire, Yeung, Wayland, Aggarwal, Ishan, Katiyar, Samiksha, Eyers, Claire E, Eyers, Patrick A, Kannan, Natarajan
Publicado 2023

Anilinoquinazoline inhibitors of the RET kinase domain—Elaboration of the 7-position

por Jordan, Allan M., Begum, Habiba, Fairweather, Emma, Fritzl, Samantha, Goldberg, Kristin, Hopkins, Gemma V., Hamilton, Niall M., Lyons, Amanda J., March, H. Nikki, Newton, Rebecca, Small, Helen F., Vishwanath, Swamy, Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Publicado 2016

Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

por Maiques-Diaz, Alba, Spencer, Gary J., Lynch, James T., Ciceri, Filippo, Williams, Emma L., Amaral, Fabio M.R., Wiseman, Daniel H., Harris, William J., Li, Yaoyong, Sahoo, Sudhakar, Hitchin, James R., Mould, Daniel P., Fairweather, Emma E., Waszkowycz, Bohdan, Jordan, Allan M., Smith, Duncan L., Somervaille, Tim C.P.
Publicado 2018

The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity

por Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Publicado 2016