Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors

por Silhan, Jan, Fajtova, Pavla, Bartosova, Jitka, Hurysz, Brianna M., Almaliti, Jehad, Miyamoto, Yukiko, Eckmann, Lars, Gerwick, William H., O’Donoghue, Anthony J., Boura, Evzen
Publicado 2023

A Dual‐Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain‐like Proteases of SARS‐CoV‐2‐Infected Cells for Accurate Detection and Rapid Inhibitor Screening...

por Cheng, Yong, Borum, Raina M., Clark, Alex E., Jin, Zhicheng, Moore, Colman, Fajtová, Pavla, O'Donoghue, Anthony J., Carlin, Aaron F., Jokerst, Jesse V.
Publicado 2022

Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors

por Fajtová, Pavla, Štefanić, Saša, Hradilek, Martin, Dvořák, Jan, Vondrášek, Jiří, Jílková, Adéla, Ulrychová, Lenka, McKerrow, James H., Caffrey, Conor R., Mareš, Michael, Horn, Martin
Publicado 2015

Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity

por Jílková, Adéla, Horn, Martin, Fanfrlík, Jindřich, Küppers, Jim, Pachl, Petr, Řezáčová, Pavlína, Lepšík, Martin, Fajtová, Pavla, Rubešová, Petra, Chanová, Marta, Caffrey, Conor R., Gütschow, Michael, Mareš, Michael
Publicado 2020

SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties

por Leontovyč, Adrian, Ulrychová, Lenka, O’Donoghue, Anthony J., Vondrášek, Jiří, Marešová, Lucie, Hubálek, Martin, Fajtová, Pavla, Chanová, Marta, Jiang, Zhenze, Craik, Charles S., Caffrey, Conor R., Mareš, Michael, Dvořák, Jan, Horn, Martin
Publicado 2018

Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L

por Meewan, Ittipat, Kattoula, Jacob, Kattoula, Julius Y., Skinner, Danielle, Fajtová, Pavla, Giardini, Miriam A., Woodworth, Brendon, McKerrow, James H., Lage de Siqueira-Neto, Jair, O’Donoghue, Anthony J., Abagyan, Ruben
Publicado 2022

Trypsin- and Chymotrypsin-Like Serine Proteases in Schistosoma mansoni – ‘The Undiscovered Country’

por Horn, Martin, Fajtová, Pavla, Rojo Arreola, Liliana, Ulrychová, Lenka, Bartošová-Sojková, Pavla, Franta, Zdeněk, Protasio, Anna V., Opavský, David, Vondrášek, Jiří, McKerrow, James H., Mareš, Michael, Caffrey, Conor R., Dvořák, Jan
Publicado 2014

Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors

por Jílková, Adéla, Rubešová, Petra, Fanfrlík, Jindřich, Fajtová, Pavla, Řezáčová, Pavlína, Brynda, Jiří, Lepšík, Martin, Mertlíková-Kaiserová, Helena, Emal, Cory D., Renslo, Adam R., Roush, William R., Horn, Martin, Caffrey, Conor R., Mareš, Michael
Publicado 2020

Peptide valence-induced breaks in plasmonic coupling

por Chang, Yu-Ci, Jin, Zhicheng, Li, Ke, Zhou, Jiajing, Yim, Wonjun, Yeung, Justin, Cheng, Yong, Retout, Maurice, Creyer, Matthew N., Fajtová, Pavla, He, Tengyu, Chen, Xi, O’Donoghue, Anthony J., Jokerst, Jesse V.
Publicado 2023

Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors

por Corrigan, Thomas S., Lotti Diaz, Leilani M., Border, Sarah E., Ratigan, Steven C., Kasper, Kayla Q., Sojka, Daniel, Fajtova, Pavla, Caffrey, Conor R., Salvesen, Guy S., McElroy, Craig A., Hadad, Christopher M., Doğan Ekici, Özlem
Publicado 2020

A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells

por Mellott, Drake M., Tseng, Chien-Te, Drelich, Aleksandra, Fajtová, Pavla, Chenna, Bala C., Kostomiris, Demetrios H., Hsu, Jason, Zhu, Jiyun, Taylor, Zane W., Tat, Vivian, Katzfuss, Ardala, Li, Linfeng, Giardini, Miriam A., Skinner, Danielle, Hirata, Ken, Beck, Sungjun, Carlin, Aaron F., Clark, Alex E., Beretta, Laura, Maneval, Daniel, Frueh, Felix, Hurst, Brett L., Wang, Hong, Kocurek, Klaudia I., Raushel, Frank M., O’Donoghue, Anthony J., de Siqueira-Neto, Jair Lage, Meek, Thomas D., McKerrow, James H.
Publicado 2020

Native metabolomics identifies the rivulariapeptolide family of protease inhibitors

por Reher, Raphael, Aron, Allegra T., Fajtová, Pavla, Stincone, Paolo, Wagner, Berenike, Pérez-Lorente, Alicia I., Liu, Chenxi, Shalom, Ido Y. Ben, Bittremieux, Wout, Wang, Mingxun, Jeong, Kyowon, Matos-Hernandez, Marie L., Alexander, Kelsey L., Caro-Diaz, Eduardo J., Naman, C. Benjamin, Scanlan, J. H. William, Hochban, Phil M. M., Diederich, Wibke E., Molina-Santiago, Carlos, Romero, Diego, Selim, Khaled A., Sass, Peter, Brötz-Oesterhelt, Heike, Hughes, Chambers C., Dorrestein, Pieter C., O’Donoghue, Anthony J., Gerwick, William H., Petras, Daniel
Publicado 2022