Gβγ activates PIP2 hydrolysis by recruiting and orienting PLCβ on the membrane surface

por Falzone, Maria E., MacKinnon, Roderick
Publicado 2023

The mechanism of Gα(q) regulation of PLCβ3-catalyzed PIP2 hydrolysis

por Falzone, Maria E., MacKinnon, Roderick
Publicado 2023

Known structures and unknown mechanisms of TMEM16 scramblases and channels

por Falzone, Maria E., Malvezzi, Mattia, Lee, Byoung-Cheol, Accardi, Alessio
Publicado 2018

Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca(2+)-bound nhTMEM16

por Khelashvili, George, Falzone, Maria E., Cheng, Xiaolu, Lee, Byoung-Cheol, Accardi, Alessio, Weinstein, Harel
Publicado 2019

TMEM16 scramblases thin the membrane to enable lipid scrambling

por Falzone, Maria E., Feng, Zhang, Alvarenga, Omar E., Pan, Yangang, Lee, ByoungCheol, Cheng, Xiaolu, Fortea, Eva, Scheuring, Simon, Accardi, Alessio
Publicado 2022

Structural basis of Ca(2+)-dependent activation and lipid transport by a TMEM16 scramblase

por Falzone, Maria E, Rheinberger, Jan, Lee, Byoung-Cheol, Peyear, Thasin, Sasset, Linda, Raczkowski, Ashleigh M, Eng, Edward T, Di Lorenzo, Annarita, Andersen, Olaf S, Nimigean, Crina M, Accardi, Alessio
Publicado 2019

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

por Bushell, Simon R., Pike, Ashley C. W., Falzone, Maria E., Rorsman, Nils J. G., Ta, Chau M., Corey, Robin A., Newport, Thomas D., Christianson, John C., Scofano, Lara F., Shintre, Chitra A., Tessitore, Annamaria, Chu, Amy, Wang, Qinrui, Shrestha, Leela, Mukhopadhyay, Shubhashish M. M., Love, James D., Burgess-Brown, Nicola A., Sitsapesan, Rebecca, Stansfeld, Phillip J., Huiskonen, Juha T., Tammaro, Paolo, Accardi, Alessio, Carpenter, Elisabeth P.
Publicado 2019