Repurposing the Kinase Inhibitor Mavelertinib for Giardiasis Therapy

por Michaels, Samantha A., Hulverson, Matthew A., Whitman, Grant R., Tran, Linh T., Choi, Ryan, Fan, Erkang, McNamara, Case W., Love, Melissa S., Ojo, Kayode K.
Publicado 2022

Identification of and Structural Insights into Hit Compounds Targeting N-Myristoyltransferase for Cryptosporidium Drug Development

por Fenwick, Michael K., Reers, Alexandra R., Liu, Yi, Zigweid, Rachael, Sankaran, Banumathi, Shin, Janis, Hulverson, Matthew A., Hammerson, Bradley, Fernández Álvaro, Elena, Myler, Peter J., Kaushansky, Alexis, Van Voorhis, Wesley C., Fan, Erkang, Staker, Bart L.
Publicado 2023

5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors

por Zhang, Zhongsheng, Koh, Cho Yeow, Ranade, Ranae M., Shibata, Sayaka, Gillespie, J. Robert, Hulverson, Matthew A., Huang, Wenlin, Nguyen, Jasmine, Pendem, Nagendar, Gelb, Michael H., Verlinde, Christophe L. M. J., Hol, Wim G. J., Buckner, Frederick S., Fan, Erkang
Publicado 2016

Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness

por Koh, Cho Yeow, Kim, Jessica E., Wetzel, Allan B., de van der Schueren, Will J., Shibata, Sayaka, Ranade, Ranae M., Liu, Jiyun, Zhang, Zhongsheng, Gillespie, J. Robert, Buckner, Frederick S., Verlinde, Christophe L. M. J., Fan, Erkang, Hol, Wim G. J.
Publicado 2014

Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy

por Ojo, Kayode K., Reid, Molly C., Kallur Siddaramaiah, Latha, Müller, Joachim, Winzer, Pablo, Zhang, Zhongsheng, Keyloun, Katelyn R., Vidadala, Rama Subba Rao, Merritt, Ethan A., Hol, Wim G. J., Maly, Dustin J., Fan, Erkang, Van Voorhis, Wesley C., Hemphill, Andrew
Publicado 2014

Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis

por Ojo, Kayode K., Ranade, Ranae M., Zhang, Zhongsheng, Dranow, David M., Myers, Janette B., Choi, Ryan, Nakazawa Hewitt, Steve, Edwards, Thomas E., Davies, Douglas R., Lorimer, Donald, Boyle, Stephen M., Barrett, Lynn K., Buckner, Frederick S., Fan, Erkang, Van Voorhis, Wesley C.
Publicado 2016

Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis

por Ojo, Kayode K., Ranade, Ranae M., Zhang, Zhongsheng, Dranow, David M., Myers, Janette B., Choi, Ryan, Nakazawa Hewitt, Steve, Edwards, Thomas E., Davies, Douglas R., Lorimer, Donald, Boyle, Stephen M., Barrett, Lynn K., Buckner, Frederick S., Fan, Erkang, Van Voorhis, Wesley C.
Publicado 2016

Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection

por Arnold, Samuel L. M., Choi, Ryan, Hulverson, Matthew A., Schaefer, Deborah A., Vinayak, Sumiti, Vidadala, Rama S. R., McCloskey, Molly C., Whitman, Grant R., Huang, Wenlin, Barrett, Lynn K., Ojo, Kayode K., Fan, Erkang, Maly, Dustin J., Riggs, Michael W., Striepen, Boris, Van Voorhis, Wesley C.
Publicado 2017

Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis

por Hulverson, Matthew A., Choi, Ryan, Schaefer, Deborah A., Betzer, Dana P., McCloskey, Molly C., Whitman, Grant R., Huang, Wenlin, Lee, Sangun, Pranata, Andy, McLeod, Malcolm D., Marsh, Kennan C., Kempf, Dale J., LeRoy, Bruce E., Zafiratos, Mark T., Bielinski, Aimee L., Hackman, Robert C., Ojo, Kayode K., Arnold, Samuel L. M., Barrett, Lynn K., Tzipori, Saul, Riggs, Michael W., Fan, Erkang, Van Voorhis, Wesley C.
Publicado 2023

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1

por Huang, Wenlin, Ojo, Kayode K., Zhang, Zhongsheng, Rivas, Kasey, Vidadala, Rama Subba Rao, Scheele, Suzanne, DeRocher, Amy E., Choi, Ryan, Hulverson, Matthew A., Barrett, Lynn K., Bruzual, Igor, Siddaramaiah, Latha Kallur, Kerchner, Keshia M., Kurnick, Matthew D., Freiberg, Gail M., Kempf, Dale, Hol, Wim G. J., Merritt, Ethan A., Neckermann, Georg, de Hostos, Eugenio L., Isoherranen, Nina, Maly, Dustin J., Parsons, Marilyn, Doggett, J. Stone, Van Voorhis, Wesley C., Fan, Erkang
Publicado 2015

Pyrazoleamide compounds are potent antimalarials that target Na(+) homeostasis in intraerythrocytic Plasmodium falciparum

por Vaidya, Akhil B., Morrisey, Joanne M., Zhang, Zhongsheng, Das, Sudipta, Daly, Thomas M., Otto, Thomas D., Spillman, Natalie J., Wyvratt, Matthew, Siegl, Peter, Marfurt, Jutta, Wirjanata, Grennady, Sebayang, Boni F., Price, Ric N., Chatterjee, Arnab, Nagle, Advait, Stasiak, Marcin, Charman, Susan A., Angulo-Barturen, Iñigo, Ferrer, Santiago, Belén Jiménez-Díaz, María, Martínez, María Santos, Gamo, Francisco Javier, Avery, Vicky M., Ruecker, Andrea, Delves, Michael, Kirk, Kiaran, Berriman, Matthew, Kortagere, Sandhya, Burrows, Jeremy, Fan, Erkang, Bergman, Lawrence W.
Publicado 2014