Revisiting CFTR Interactions: Old Partners and New Players

por Farinha, Carlos M., Gentzsch, Martina
Publicado 2021

Molecular mechanisms of cystic fibrosis – how mutations lead to misfunction and guide therapy

por Farinha, Carlos M., Callebaut, Isabelle
Publicado 2022

Unraveling the Function of Lemur Tyrosine Kinase 2 Network

por Cruz, Daniel F., Farinha, Carlos M., Swiatecka-Urban, Agnieszka
Publicado 2019

The bidirectional relationship between CFTR and lipids

por Cottrill, Kirsten A., Farinha, Carlos M., McCarty, Nael A.
Publicado 2020

Regulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity

por Farinha, Carlos M., Swiatecka-Urban, Agnieszka, Brautigan, David L., Jordan, Peter
Publicado 2016

TGF-β1 Augments the Apical Membrane Abundance of Lemur Tyrosine Kinase 2 to Inhibit CFTR-Mediated Chloride Transport in Human Bronchial Epithelia

por Cruz, Daniel F., Mitash, Nilay, Farinha, Carlos M., Swiatecka-Urban, Agnieszka
Publicado 2020

Rare Trafficking CFTR Mutations Involve Distinct Cellular Retention Machineries and Require Different Rescuing Strategies

por Ramalho, Sofia S., Silva, Iris A. L., Amaral, Margarida D., Farinha, Carlos M.
Publicado 2021

Differential Gene Expression Analysis Reveals Global LMTK2 Regulatory Network and Its Role in TGF-β1 Signaling

por Cruz, Daniel F., Mitash, Nilay, Mu, Fangping, Farinha, Carlos M., Swiatecka-Urban, Agnieszka
Publicado 2021

Rescue of Rare CFTR Trafficking Mutants Highlights a Structural Location-Dependent Pattern for Correction

por Zacarias, Sónia, Batista, Marta S. P., Ramalho, Sofia S., Victor, Bruno L., Farinha, Carlos M.
Publicado 2023

Increased efficacy of VX-809 in different cellular systems results from an early stabilization effect of F508del-CFTR

por Farinha, Carlos M, Sousa, Marisa, Canato, Sara, Schmidt, André, Uliyakina, Inna, Amaral, Margarida D
Publicado 2015

Absence of EPAC1 Signaling to Stabilize CFTR in Intestinal Organoids

por Ferreira, João F., Silva, Iris A. L., Botelho, Hugo M., Amaral, Margarida D., Farinha, Carlos M.
Publicado 2022

LMTK2-mediated Phosphorylation Regulates CFTR Endocytosis in Human Airway Epithelial Cells

por Luz, Simão, Cihil, Kristine M., Brautigan, David L., Amaral, Margarida D., Farinha, Carlos M., Swiatecka-Urban, Agnieszka
Publicado 2014

Integrity and Stability of PTC Bearing CFTR mRNA and Relevance to Future Modulator Therapies in Cystic Fibrosis

por Clarke, Luka A., Luz, Vanessa C. C., Targowski, Szymon, Ramalho, Sofia S., Farinha, Carlos M., Amaral, Margarida D.
Publicado 2021

Mechanical Properties of Human Bronchial Epithelial Cells Expressing Wt- and Mutant CFTR

por Carapeto, Ana P., Vitorino, Miguel V., Santos, João D., Ramalho, Sofia S., Robalo, Tiago, Rodrigues, Mário S., Farinha, Carlos M.
Publicado 2020

Network Biology Identifies Novel Regulators of CFTR Trafficking and Membrane Stability

por Loureiro, Cláudia Almeida, Santos, João D., Matos, Ana Margarida, Jordan, Peter, Matos, Paulo, Farinha, Carlos M., Pinto, Francisco R.
Publicado 2019

Mutation-class dependent signatures outweigh disease-associated processes in cystic fibrosis cells

por Santos, Lúcia, Nascimento, Rui, Duarte, Aires, Railean, Violeta, Amaral, Margarida D., Harrison, Patrick T., Gama-Carvalho, Margarida, Farinha, Carlos M.
Publicado 2023

Personalized medicine: Function of CFTR variant p.Arg334Trp is rescued by currently available CFTR modulators

por Railean, Violeta, Rodrigues, Cláudia S., Ramalho, Sofia S., Silva, Iris A. L., Bartosch, Jan, Farinha, Carlos M., Pankonien, Ines, Amaral, Margarida D.
Publicado 2023

Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis

por Awatade, Nikhil T., Uliyakina, Inna, Farinha, Carlos M., Clarke, Luka A., Mendes, Karina, Solé, Amparo, Pastor, Juan, Ramos, Maria Margarida, Amaral, Margarida D.
Publicado 2014

Full Rescue of F508del-CFTR Processing and Function by CFTR Modulators Can Be Achieved by Removal of Two Regulatory Regions

por Uliyakina, Inna, Botelho, Hugo M., da Paula, Ana C., Afonso, Sara, Lobo, Miguel J., Felício, Verónica, Farinha, Carlos M., Amaral, Margarida D.
Publicado 2020

CyFi-MAP: an interactive pathway-based resource for cystic fibrosis

por Pereira, Catarina, Mazein, Alexander, Farinha, Carlos M., Gray, Michael A., Kunzelmann, Karl, Ostaszewski, Marek, Balaur, Irina, Amaral, Margarida D., Falcao, Andre O.
Publicado 2021