X‐ray crystal structure localizes the mechanism of inhibition of an IL‐36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains

por Larson, Eric T., Brennan, Debra L., Hickey, Eugene R., Ganesan, Raj, Kroe‐Barrett, Rachel, Farrow, Neil A.
Publicado 2020

Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies

por Alford, Joshua S., Lampe, John W., Brach, Dorothy, Chesworth, Richard, Cosmopoulos, Kat, Duncan, Kenneth W., Eckley, Sean T., Kutok, Jeffrey L., Raimondi, Alejandra, Riera, Thomas V., Shook, Brian, Tang, Cuyue, Totman, Jennifer, Farrow, Neil A.
Publicado 2022

Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies

por Lampe, John W., Alford, Joshua S., Boriak-Sjodin, P. Ann, Brach, Dorothy, Cosmopoulos, Kat, Duncan, Kenneth W., Eckley, Sean T., Foley, Megan A., Harvey, Darren M., Motwani, Vinny, Munchhof, Michael J., Raimondi, Alejandra, Riera, Thomas V., Tang, Cuyue, Thomenius, Michael J., Totman, Jennifer, Farrow, Neil A.
Publicado 2021

Indole Inhibitors of MMP-13 for Arthritic Disorders

por Taylor, Steven J., Abeywardane, Asitha, Liang, Shuang, Xiong, Zhaoming, Proudfoot, John R., Farmer, Bennett Sandy, Gao, Donghong A., Heim-Riether, Alexander, Smith-Keenan, Lana Louise, Muegge, Ingo, Yu, Yang, Zhang, Qiang, Souza, Donald, Panzenbeck, Mark, Goldberg, Daniel, Hill-Drzewi, Melissa, Margarit, Mariana, Collins, Brandon, Li, John Xiang, Zuvela-Jelaska, Ljiljana, Li, Jun, Farrow, Neil A.
Publicado 2021