Altered native stability is the dominant basis for susceptibility of α(1)-antitrypsin mutants to polymerization

por Irving, James A., Haq, Imran, Dickens, Jennifer A., Faull, Sarah V., Lomas, David A.
Publicado 2014

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

por Haq, Imran, Irving, James A., Faull, Sarah V., Dickens, Jennifer A., Ordóñez, Adriana, Belorgey, Didier, Gooptu, Bibek, Lomas, David A.
Publicado 2013

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

por Haq, Imran, Irving, James A., Faull, Sarah V., Dickens, Jennifer A., Ordóñez, Adriana, Belorgey, Didier, Gooptu, Bibek, Lomas, David A.
Publicado 2013

An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein

por Irving, James A., Miranda, Elena, Haq, Imran, Perez, Juan, Kotov, Vadim R., Faull, Sarah V., Motamedi-Shad, Neda, Lomas, David A.
Publicado 2015

Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome

por Faull, Sarah V., Lau, Andy M. C., Martens, Chloe, Ahdash, Zainab, Hansen, Kjetil, Yebenes, Hugo, Schmidt, Carla, Beuron, Fabienne, Cronin, Nora B., Morris, Edward P., Politis, Argyris
Publicado 2019

An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour

por Motamedi-Shad, Neda, Jagger, Alistair M., Liedtke, Maximilian, Faull, Sarah V., Nanda, Arjun Scott, Salvadori, Enrico, Wort, Joshua L., Kay, Christopher W.M., Heyer-Chauhan, Narinder, Miranda, Elena, Perez, Juan, Ordóñez, Adriana, Haq, Imran, Irving, James A., Lomas, David A.
Publicado 2016

The structural basis for Z α(1)-antitrypsin polymerization in the liver

por Faull, Sarah V., Elliston, Emma L. K., Gooptu, Bibek, Jagger, Alistair M., Aldobiyan, Ibrahim, Redzej, Adam, Badaoui, Magd, Heyer-Chauhan, Nina, Rashid, S. Tamir, Reynolds, Gary M., Adams, David H., Miranda, Elena, Orlova, Elena V., Irving, James A., Lomas, David A.
Publicado 2020