The C-Terminal Threonine of Aβ43 Nucleates Toxic Aggregation via Structural and Dynamical Changes in Monomers and Protofibrils

por Conicella, Alexander E., Fawzi, Nicolas L.
Publicado 2014

Structure and position-specific interactions of prion-like domains in transcription factor Efg1 phase separation

por Wang, Szu-Huan, Zheng, Tongyin, Fawzi, Nicolas L.
Publicado 2023

Editorial: The Role of Protein Post-Translational Modifications in Protein-RNA Interactions and RNP Assemblies

por Giambruno, Roberto, Grzybowska, Ewa A., Fawzi, Nicolas L., Dormann, Dorothee
Publicado 2022

Atomic resolution dynamics on the surface of amyloid β protofibrils probed by solution NMR

por Fawzi, Nicolas L., Ying, Jinfa, Ghirlando, Rodolfo, Torchia, Dennis A., Clore, G. Marius
Publicado 2011

SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation stimulated by RNA and partitions into phases of human ribonucleoproteins.

por Perdikari, Theodora Myrto, Murthy, Anastasia C., Ryan, Veronica H., Watters, Scott, Naik, Mandar T., Fawzi, Nicolas L.
Publicado 2020

Weak binding to the A2RE RNA rigidifies hnRNPA2 RRMs and reduces liquid–liquid phase separation and aggregation

por Ryan, Veronica H, Watters, Scott, Amaya, Joshua, Khatiwada, Balabhadra, Venditti, Vincenzo, Naik, Mandar T, Fawzi, Nicolas L
Publicado 2020

SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs

por Perdikari, Theodora Myrto, Murthy, Anastasia C, Ryan, Veronica H, Watters, Scott, Naik, Mandar T, Fawzi, Nicolas L
Publicado 2020

EGFP insertional mutagenesis reveals multiple FXR2P fibrillar states with differing ribosome association in neurons

por Stackpole, Emily E., Akins, Michael R., Ivshina, Maria, Murthy, Anastasia C., Fawzi, Nicolas L., Fallon, Justin R.
Publicado 2019

Molecular interactions underlying liquid-liquid phase separation of the FUS low complexity domain

por Murthy, Anastasia C., Dignon, Gregory L., Kan, Yelena, Zerze, Gül H., Parekh, Sapun H., Mittal, Jeetain, Fawzi, Nicolas L.
Publicado 2019

Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): a new bacteriostatic agent against methicillin—resistant Staphylococcus aureus

por Johnston, Tatiana, Van Tyne, Daria, Chen, Roy F., Fawzi, Nicolas L., Kwon, Bumsup, Kelso, Michael J., Gilmore, Michael S., Mylonakis, Eleftherios
Publicado 2018

Differential Occupancy of Two GA-Binding Proteins Promotes Targeting of the Drosophila Dosage Compensation Complex to the Male X Chromosome

por Kaye, Emily G., Booker, Matthew, Kurland, Jesse V., Conicella, Alexander E., Fawzi, Nicolas L., Bulyk, Martha L., Tolstorukov, Michael Y., Larschan, Erica
Publicado 2018

Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration

por Ryan, Veronica H, Perdikari, Theodora M, Naik, Mandar T, Saueressig, Camillo F, Lins, Jeremy, Dignon, Gregory L, Mittal, Jeetain, Hart, Anne C, Fawzi, Nicolas L
Publicado 2020

Fibril formation and ordering of disordered FUS LC driven by hydrophobic interactions

por Maltseva, Daria, Chatterjee, Sayantan, Yu, Chun-Chieh, Brzezinski, Mateusz, Nagata, Yuki, Gonella, Grazia, Murthy, Anastasia C., Stachowiak, Jeanne C., Fawzi, Nicolas L., Parekh, Sapun H., Bonn, Mischa
Publicado 2023

Intrinsically disordered regions and RNA binding domains contribute to protein enrichment in biomolecular condensates in Xenopus oocytes

por O’Connell, Liam C., Johnson, Victoria, Hutton, Anika K., Otis, Jessica P., Murthy, Anastasia C., Liang, Mark C., Wang, Szu-Huan, Fawzi, Nicolas L., Mowry, Kimberly L.
Publicado 2023

Reversible Kinetic Trapping of FUS Biomolecular Condensates

por Chatterjee, Sayantan, Kan, Yelena, Brzezinski, Mateusz, Koynov, Kaloian, Regy, Roshan Mammen, Murthy, Anastasia C., Burke, Kathleen A., Michels, Jasper J., Mittal, Jeetain, Fawzi, Nicolas L., Parekh, Sapun H.
Publicado 2021

TDP-43 α-helical structure tunes liquid–liquid phase separation and function

por Conicella, Alexander E., Dignon, Gregory L., Zerze, Gül H., Schmidt, Hermann Broder, D’Ordine, Alexandra M., Kim, Young C., Rohatgi, Rajat, Ayala, Yuna M., Mittal, Jeetain, Fawzi, Nicolas L.
Publicado 2020

Epigenetic Cell Fate in Candida albicans is Controlled by Transcription Factor Condensates Acting at Super-Enhancer-Like Elements

por Frazer, Corey, Staples, Mae I., Kim, Yoori, Hirakawa, Matthew, Dowell, Maureen A., Johnson, Nicole V., Hernday, Aaron D., Ryan, Veronica H., Fawzi, Nicolas L., Finkelstein, Ilya J., Bennett, Richard J.
Publicado 2020

A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing

por Wang, Ailin, Conicella, Alexander E, Schmidt, Hermann Broder, Martin, Erik W, Rhoads, Shannon N, Reeb, Ashley N, Nourse, Amanda, Ramirez Montero, Daniel, Ryan, Veronica H, Rohatgi, Rajat, Shewmaker, Frank, Naik, Mandar T, Mittag, Tanja, Ayala, Yuna M, Fawzi, Nicolas L
Publicado 2018

Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity

por Monahan, Zachary, Ryan, Veronica H, Janke, Abigail M, Burke, Kathleen A, Rhoads, Shannon N, Zerze, Gül H, O'Meally, Robert, Dignon, Gregory L, Conicella, Alexander E, Zheng, Wenwei, Best, Robert B, Cole, Robert N, Mittal, Jeetain, Shewmaker, Frank, Fawzi, Nicolas L
Publicado 2017

TDP-43 condensation properties specify its RNA-binding and regulatory repertoire

por Hallegger, Martina, Chakrabarti, Anob M., Lee, Flora C.Y., Lee, Bo Lim, Amalietti, Aram G., Odeh, Hana M., Copley, Katie E., Rubien, Jack D., Portz, Bede, Kuret, Klara, Huppertz, Ina, Rau, Frédérique, Patani, Rickie, Fawzi, Nicolas L., Shorter, James, Luscombe, Nicholas M., Ule, Jernej
Publicado 2021