Genetic conservation across SARS-CoV-2 non-structural proteins – Insights into possible targets for treatment of future viral outbreaks

por Kandwal, Shubhangi, Fayne, Darren
Publicado 2023

DataPype: A Fully Automated Unified Software Platform for Computer-Aided Drug Design

por Khan, Mohemmed Faraz, Kandwal, Shubhangi, Fayne, Darren
Publicado 2023

Single point mutations reveal amino acid residues important for Chromobacterium violaceum transaminase activity in the production of unnatural amino acids

por Almahboub, Sarah A., Narancic, Tanja, Fayne, Darren, O’Connor, Kevin E.
Publicado 2018

Synthesis, Anti-proliferative Activity, and Molecular Docking Study of New Series of 1,3-5-Triazine Schiff Base Derivatives

por Al Rasheed, Hessa H., Malebari, Azizah M., Dahlous, Kholood A., Fayne, Darren, El-Faham, Ayman
Publicado 2020

Novel Selective Estrogen Receptor Ligand Conjugates Incorporating Endoxifen-Combretastatin and Cyclofenil-Combretastatin Hybrid Scaffolds: Synthesis and Biochemical Evaluation

por Kelly, Patrick M., Keely, Niall O., Bright, Sandra A., Yassin, Bassem, Ana, Gloria, Fayne, Darren, Zisterer, Daniela M., Meegan, Mary J.
Publicado 2017

“True” Antiandrogens—Selective Non-Ligand-Binding Pocket Disruptors of Androgen Receptor–Coactivator Interactions: Novel Tools for Prostate Cancer

por Caboni, Laura, Kinsella, Gemma K., Blanco, Fernando, Fayne, Darren, Jagoe, William N., Carr, Miriam, Williams, D. Clive, Meegan, Mary J., Lloyd, David G.
Publicado 2012

Comprehensive Characterization of Cytochrome P450 Isozyme Selectivity across Chemical Libraries

por Veith, Henrike, Southall, Noel, Huang, Ruili, James, Tim, Fayne, Darren, Artemenko, Natalia, Shen, Min, Inglese, James, Austin, Christopher P., Lloyd, David G., Auld, Douglas S.
Publicado 2009

Design, Synthesis and Biochemical Evaluation of Novel Ethanoanthracenes and Related Compounds to Target Burkitt’s Lymphoma

por Byrne, Andrew J., Bright, Sandra A., McKeown, James P., O’Brien, John E., Twamley, Brendan, Fayne, Darren, Williams, D. Clive, Meegan, Mary J.
Publicado 2020

Antiproliferative and Tubulin-Destabilising Effects of 3-(Prop-1-en-2-yl)azetidin-2-Ones and Related Compounds in MCF-7 and MDA-MB-231 Breast Cancer Cells

por Wang, Shu, Malebari, Azizah M., Greene, Thomas F., Kandwal, Shubhangi, Fayne, Darren, Nathwani, Seema M., Zisterer, Daniela M., Twamley, Brendan, O’Boyle, Niamh M., Meegan, Mary J.
Publicado 2023

Synthesis, Characterisation and Mechanism of Action of Anticancer 3-Fluoroazetidin-2-ones

por Malebari, Azizah M., Duffy Morales, Gabriela, Twamley, Brendan, Fayne, Darren, Khan, Mohemmed Faraz, McLoughlin, Eavan C., O’Boyle, Niamh M., Zisterer, Daniela M., Meegan, Mary J.
Publicado 2022

3-Vinylazetidin-2-Ones: Synthesis, Antiproliferative and Tubulin Destabilizing Activity in MCF-7 and MDA-MB-231 Breast Cancer Cells

por Wang, Shu, Malebari, Azizah M., Greene, Thomas F., O’Boyle, Niamh M., Fayne, Darren, Nathwani, Seema M., Twamley, Brendan, McCabe, Thomas, Keely, Niall O., Zisterer, Daniela M., Meegan, Mary J.
Publicado 2019

Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4

por Malebari, Azizah M., Wang, Shu, Greene, Thomas F., O’Boyle, Niamh M., Fayne, Darren, Khan, Mohemmed Faraz, Nathwani, Seema M., Twamley, Brendan, McCabe, Thomas, Zisterer, Daniela M., Meegan, Mary J.
Publicado 2021

Synthesis and Biological Evaluation of 1-(Diarylmethyl)-1H-1,2,4-triazoles and 1-(Diarylmethyl)-1H-imidazoles as a Novel Class of Anti-Mitotic Agent for Activity in Breast Cancer

por Ana, Gloria, Kelly, Patrick M., Malebari, Azizah M., Noorani, Sara, Nathwani, Seema M., Twamley, Brendan, Fayne, Darren, O’Boyle, Niamh M., Zisterer, Daniela M., Pimentel, Elisangela Flavia, Endringer, Denise Coutinho, Meegan, Mary J.
Publicado 2021