Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice

por Beel, Sander, Herdewyn, Sarah, Fazal, Raheem, De Decker, Mathias, Moisse, Matthieu, Robberecht, Wim, Van Den Bosch, Ludo, Van Damme, Philip
Publicado 2018

A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons

por Beckers, Jimmy, Tharkeshwar, Arun Kumar, Fumagalli, Laura, Contardo, Matilde, Van Schoor, Evelien, Fazal, Raheem, Thal, Dietmar Rudolf, Chandran, Siddharthan, Mancuso, Renzo, Van Den Bosch, Ludo, Van Damme, Philip
Publicado 2023

HDAC6 inhibition restores TDP‐43 pathology and axonal transport defects in human motor neurons with TARDBP mutations

por Fazal, Raheem, Boeynaems, Steven, Swijsen, Ann, De Decker, Mathias, Fumagalli, Laura, Moisse, Matthieu, Vanneste, Joni, Guo, Wenting, Boon, Ruben, Vercruysse, Thomas, Eggermont, Kristel, Swinnen, Bart, Beckers, Jimmy, Pakravan, Donya, Vandoorne, Tijs, Vanden Berghe, Pieter, Verfaillie, Catherine, Van Den Bosch, Ludo, Van Damme, Philip
Publicado 2021

Differentiation but not ALS mutations in FUS rewires motor neuron metabolism

por Vandoorne, Tijs, Veys, Koen, Guo, Wenting, Sicart, Adria, Vints, Katlijn, Swijsen, Ann, Moisse, Matthieu, Eelen, Guy, Gounko, Natalia V., Fumagalli, Laura, Fazal, Raheem, Germeys, Christine, Quaegebeur, Annelies, Fendt, Sarah-Maria, Carmeliet, Peter, Verfaillie, Catherine, Van Damme, Philip, Ghesquière, Bart, De Bock, Katrien, Van Den Bosch, Ludo
Publicado 2019

C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility

por Fumagalli, Laura, Young, Florence L., Boeynaems, Steven, De Decker, Mathias, Mehta, Arpan R., Swijsen, Ann, Fazal, Raheem, Guo, Wenting, Moisse, Matthieu, Beckers, Jimmy, Dedeene, Lieselot, Selvaraj, Bhuvaneish T., Vandoorne, Tijs, Madan, Vanesa, van Blitterswijk, Marka, Raitcheva, Denitza, McCampbell, Alexander, Poesen, Koen, Gitler, Aaron D., Koch, Philipp, Berghe, Pieter Vanden, Thal, Dietmar Rudolf, Verfaillie, Catherine, Chandran, Siddharthan, Van Den Bosch, Ludo, Bullock, Simon L., Van Damme, Philip
Publicado 2021