Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site

por Chen, Shu-Yu, Feilen, Lukas P., Chávez-Gutiérrez, Lucía, Steiner, Harald, Zacharias, Martin
Publicado 2023

Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin

por Schmidt, Fabian C., Fitz, Katja, Feilen, Lukas P., Okochi, Masayasu, Steiner, Harald, Langosch, Dieter
Publicado 2023

Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis

por Feilen, Lukas P, Chen, Shu-Yu, Fukumori, Akio, Feederle, Regina, Zacharias, Martin, Steiner, Harald
Publicado 2022

Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction

por Feilen, Lukas P., Haubrich, Kevin, Strecker, Paul, Probst, Sabine, Eggert, Simone, Stier, Gunter, Sinning, Irmgard, Konietzko, Uwe, Kins, Stefan, Simon, Bernd, Wild, Klemens
Publicado 2017