Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors

por Ran, Yong, Ladd, Gabriela Z., Ceballos-Diaz, Carolina, Jung, Joo In, Greenbaum, Doron, Felsenstein, Kevin M., Golde, Todd E.
Publicado 2015

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology

por Das, Pritam, Verbeeck, Christophe, Minter, Lisa, Chakrabarty, Paramita, Felsenstein, Kevin, Kukar, Thomas, Maharvi, Ghulam, Fauq, Abdul, Osborne, Barbara A, Golde, Todd E
Publicado 2012

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity

por Jung, Joo In, Premraj, Sasha, Cruz, Pedro E., Ladd, Thomas B., Kwak, Yewon, Koo, Edward H., Felsenstein, Kevin M., Golde, Todd E., Ran, Yong
Publicado 2014

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators

por Jung, Joo In, Ran, Yong, Cruz, Pedro E., Rosario, Awilda M., Ladd, Thomas B., Kukar, Thomas L., Koo, Edward H., Felsenstein, Kevin M., Golde, Todd E.
Publicado 2014

Harnessing endogenous pathways and metabolites to treat or prevent neurodegenerative disease

por Golde, Todd E, Felsenstein, Kevin, Chakrabarty, Paramita, Li, Andy, Moore, Brenda, In, Jung Joo, Cruz, Pedor, Price, Ashely, Borchelt, David, Janus, Christopher, Cebballos-Diaz, Carolina, Rosario, Awilda
Publicado 2013

Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator

por Jung, Joo In, Price, Ashleigh R., Ladd, Thomas B., Ran, Yong, Park, Hyo-Jin, Ceballos-Diaz, Carolina, Smithson, Lisa A., Hochhaus, Günther, Tang, Yufei, Akula, Rajender, Ba, Saritha, Koo, Edward H., Shapiro, Gideon, Felsenstein, Kevin M., Golde, Todd E.
Publicado 2015

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice

por Rogers, Kathryn, Felsenstein, Kevin M, Hrdlicka, Lori, Tu, Zhiming, Albayya, Faris, Lee, Winnie, Hopp, Sarah, Miller, Mary-Jo, Spaulding, Darcie, Yang, Zhiyong, Hodgdon, Hilliary, Nolan, Scott, Wen, Melody, Costa, Don, Blain, Jean-Francois, Freeman, Emily, De Strooper, Bart, Vulsteke, Veerle, Scrocchi, Louise, Zetterberg, Henrik, Portelius, Erik, Hutter-Paier, Birgit, Havas, Daniel, Ahlijanian, Michael, Flood, Dorothy, Leventhal, Liza, Shapiro, Gideon, Patzke, Holger, Chesworth, Richard, Koenig, Gerhard
Publicado 2012