Caspase-8: not so silently deadly

por Feltham, Rebecca, Vince, James E, Lawlor, Kate E
Publicado 2017

Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

por Linossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J., Nicholson, Sandra E.
Publicado 2023

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

por Jaco, Isabel, Annibaldi, Alessandro, Lalaoui, Najoua, Wilson, Rebecca, Tenev, Tencho, Laurien, Lucie, Kim, Chun, Jamal, Kunzah, Wicky John, Sidonie, Liccardi, Gianmaria, Chau, Diep, Murphy, James M., Brumatti, Gabriela, Feltham, Rebecca, Pasparakis, Manolis, Silke, John, Meier, Pascal
Publicado 2017

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

por Linossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J., Nicholson, Sandra E.
Publicado 2021

The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

por Vijayaraj, Swarna L., Feltham, Rebecca, Rashidi, Maryam, Frank, Daniel, Liu, Zhengyang, Simpson, Daniel S., Ebert, Gregor, Vince, Angelina, Herold, Marco J., Kueh, Andrew, Pearson, Jaclyn S., Dagley, Laura F., Murphy, James M., Webb, Andrew I., Lawlor, Kate E., Vince, James E.
Publicado 2021

The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles

por Orme, Mariam H., Liccardi, Gianmaria, Moderau, Nina, Feltham, Rebecca, Wicky-John, Sidonie, Tenev, Tencho, Aram, Lior, Wilson, Rebecca, Bianchi, Katiuscia, Morris, Otto, Monteiro Domingues, Celia, Robertson, David, Tare, Meghana, Wepf, Alexander, Williams, David, Bergmann, Andreas, Gstaiger, Matthias, Arama, Eli, Ribeiro, Paulo S., Meier, Pascal
Publicado 2016

Design and characterization of a heterobifunctional degrader of KEAP1

por Chen, Hao, Nguyen, Nghi H., Magtoto, Charlene M., Cobbold, Simon A., Bidgood, Grace M., Meza Guzman, Lizeth G., Richardson, Lachlan W., Corbin, Jason, Au, Amanda E., Lechtenberg, Bernhard C., Feltham, Rebecca, Sutherland, Kate D., Grohmann, Christoph, Nicholson, Sandra E., Sleebs, Brad E.
Publicado 2022

Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1’s Cytotoxic Potential

por Feltham, Rebecca, Jamal, Kunzah, Tenev, Tencho, Liccardi, Gianmaria, Jaco, Isabel, Domingues, Celia Monteiro, Morris, Otto, John, Sidonie Wicky, Annibaldi, Alessandro, Widya, Marcella, Kearney, Conor J., Clancy, Danielle, Elliott, Paul R., Glatter, Timo, Qiao, Qi, Thompson, Andrew J., Nesvizhskii, Alexey, Schmidt, Alexander, Komander, David, Wu, Hao, Martin, Seamus, Meier, Pascal
Publicado 2018

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

por Grohmann, Christoph, Magtoto, Charlene M., Walker, Joel R., Chua, Ngee Kiat, Gabrielyan, Anna, Hall, Mary, Cobbold, Simon A., Mieruszynski, Stephen, Brzozowski, Martin, Simpson, Daniel S., Dong, Hao, Dorizzi, Bridget, Jacobsen, Annette V., Morrish, Emma, Silke, Natasha, Murphy, James M., Heath, Joan K., Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Lessene, Guillaume, Silke, John, Feltham, Rebecca
Publicado 2022

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation

por Liccardi, Gianmaria, Ramos Garcia, Laura, Tenev, Tencho, Annibaldi, Alessandro, Legrand, Arnaud J., Robertson, David, Feltham, Rebecca, Anderton, Holly, Darding, Maurice, Peltzer, Nieves, Dannappel, Marius, Schünke, Hannah, Fava, Luca L., Haschka, Manuel D., Glatter, Timo, Nesvizhskii, Alexey, Schmidt, Alexander, Harris, Philip A., Bertin, John, Gough, Peter J., Villunger, Andreas, Silke, John, Pasparakis, Manolis, Bianchi, Katiuscia, Meier, Pascal
Publicado 2019

Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death

por Frank, Daniel, Garnish, Sarah E., Sandow, Jarrod J., Weir, Ashley, Liu, Lin, Clayer, Elise, Meza, Lizeth, Rashidi, Maryam, Cobbold, Simon A., Scutts, Simon R., Doerflinger, Marcel, Anderton, Holly, Lawlor, Kate E., Lalaoui, Najoua, Kueh, Andrew J., Eng, Vik Ven, Ambrose, Rebecca L., Herold, Marco J., Samson, Andre L., Feltham, Rebecca, Murphy, James M., Ebert, Gregor, Pearson, Jaclyn S., Vince, James E.
Publicado 2022

Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer

por Nguyen, Paul M., Dagley, Laura F., Preaudet, Adele, Lam, Nga, Giam, Maybelline, Fung, Ka Yee, Aizel, Kaheina, van Duijneveldt, Gemma, Tan, Chin Wee, Hirokawa, Yumiko, Yip, Hon Yan K., Love, Christopher G., Poh, Ashleigh R., Cruz, Akshay D’, Burstroem, Charlotte, Feltham, Rebecca, Abdirahman, Suad M., Meiselbach, Kristy, Low, Ronnie Ren Jie, Palmieri, Michelle, Ernst, Matthias, Webb, Andrew I., Burgess, Tony, Sieber, Oliver M., Bouillet, Philippe, Putoczki, Tracy L.
Publicado 2019

An Erg-driven transcriptional program controls B cell lymphopoiesis

por Ng, Ashley P., Coughlan, Hannah D., Hediyeh-zadeh, Soroor, Behrens, Kira, Johanson, Timothy M., Low, Michael Sze Yuan, Bell, Charles C., Gilan, Omer, Chan, Yih-Chih, Kueh, Andrew J., Boudier, Thomas, Feltham, Rebecca, Gabrielyan, Anna, DiRago, Ladina, Hyland, Craig D., Ierino, Helen, Mifsud, Sandra, Viney, Elizabeth, Willson, Tracy, Dawson, Mark A., Allan, Rhys S., Herold, Marco J., Rogers, Kelly, Tarlinton, David M., Smyth, Gordon K., Davis, Melissa J., Nutt, Stephen L., Alexander, Warren S.
Publicado 2020

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

por Klemm, Theresa, Ebert, Gregor, Calleja, Dale J, Allison, Cody C, Richardson, Lachlan W, Bernardini, Jonathan P, Lu, Bernadine GC, Kuchel, Nathan W, Grohmann, Christoph, Shibata, Yuri, Gan, Zhong Yan, Cooney, James P, Doerflinger, Marcel, Au, Amanda E, Blackmore, Timothy R, van der Heden van Noort, Gerbrand J, Geurink, Paul P, Ovaa, Huib, Newman, Janet, Riboldi‐Tunnicliffe, Alan, Czabotar, Peter E, Mitchell, Jeffrey P, Feltham, Rebecca, Lechtenberg, Bernhard C, Lowes, Kym N, Dewson, Grant, Pellegrini, Marc, Lessene, Guillaume, Komander, David
Publicado 2020

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

por Simpson, Daniel S., Pang, Jiyi, Weir, Ashley, Kong, Isabella Y., Fritsch, Melanie, Rashidi, Maryam, Cooney, James P., Davidson, Kathryn C., Speir, Mary, Djajawi, Tirta M., Hughes, Sebastian, Mackiewicz, Liana, Dayton, Merle, Anderton, Holly, Doerflinger, Marcel, Deng, Yexuan, Huang, Allan Shuai, Conos, Stephanie A., Tye, Hazel, Chow, Seong H., Rahman, Arfatur, Norton, Raymond S., Naderer, Thomas, Nicholson, Sandra E., Burgio, Gaetan, Man, Si Ming, Groom, Joanna R., Herold, Marco J., Hawkins, Edwin D., Lawlor, Kate E., Strasser, Andreas, Silke, John, Pellegrini, Marc, Kashkar, Hamid, Feltham, Rebecca, Vince, James E.
Publicado 2022