Harnessing Antibody-Mimetic Selectivity for Activation-State-Specific Targeted Degradation of Endogenous K-Ras

por Ferguson, Fleur M.
Publicado 2021

Editorial: E3 ubiquitin ligases: From structure to physiology to therapeutics, Volume II

por Licchesi, Julien D. F., Laman, Heike, Ikeda, Fumiyo, Ferguson, Fleur M., Bolanos-Garcia, Victor M.
Publicado 2022

Molecular Basis of Histone Tail Recognition by Human TIP5 PHD Finger and Bromodomain of the Chromatin Remodeling Complex NoRC

por Tallant, Cynthia, Valentini, Erica, Fedorov, Oleg, Overvoorde, Lois, Ferguson, Fleur M., Filippakopoulos, Panagis, Svergun, Dmitri I., Knapp, Stefan, Ciulli, Alessio
Publicado 2015

A Biotin Targeting Chimera (BioTAC) System to Map Small Molecule Interactomes in situ

por Tao, Andrew J., Jiang, Jiewei, Gadbois, Gillian E., Goyal, Pavitra, Boyle, Bridget T., Mumby, Elizabeth J., Myers, Samuel A, English, Justin G., Ferguson, Fleur M.
Publicado 2023

A biotin targeting chimera (BioTAC) system to map small molecule interactomes in situ

por Tao, Andrew J., Jiang, Jiewei, Gadbois, Gillian E., Goyal, Pavitra, Boyle, Bridget T., Mumby, Elizabeth J., Myers, Samuel A., English, Justin G., Ferguson, Fleur M.
Publicado 2023

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

por Ferguson, Fleur M., Fedorov, Oleg, Chaikuad, Apirat, Philpott, Martin, Muniz, Joao R. C., Felletar, Ildiko, von Delft, Frank, Heightman, Tom, Knapp, Stefan, Abell, Chris, Ciulli, Alessio
Publicado 2013

Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy

por Silva, M. Catarina, Nandi, Ghata, Donovan, Katherine A., Cai, Quan, Berry, Bethany C., Nowak, Radoslaw P., Fischer, Eric S., Gray, Nathanael S., Ferguson, Fleur M., Haggarty, Stephen J.
Publicado 2022

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

por Nabet, Behnam, Ferguson, Fleur M., Seong, Bo Kyung A., Kuljanin, Miljan, Leggett, Alan L., Mohardt, Mikaela L., Robichaud, Amanda, Conway, Amy S., Buckley, Dennis L., Mancias, Joseph D., Bradner, James E., Stegmaier, Kimberly, Gray, Nathanael S.
Publicado 2020

Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models

por Silva, M Catarina, Ferguson, Fleur M, Cai, Quan, Donovan, Katherine A, Nandi, Ghata, Patnaik, Debasis, Zhang, Tinghu, Huang, Hai-Tsang, Lucente, Diane E, Dickerson, Bradford C, Mitchison, Timothy J, Fischer, Eric S, Gray, Nathanael S, Haggarty, Stephen J
Publicado 2019

Selective Mediator-dependence of cell type-specifying transcription

por Jaeger, Martin G., Schwalb, Björn, Mackowiak, Sebastian D., Velychko, Taras, Hanzl, Alexander, Imrichova, Hana, Brand, Matthias, Agerer, Benedikt, Chorn, Someth, Nabet, Behnam, Ferguson, Fleur M., Müller, André C., Bergthaler, Andreas, Gray, Nathanael S., Bradner, James E., Bock, Christoph, Hnisz, Denes, Cramer, Patrick, Winter, Georg E.
Publicado 2020

TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma

por Seong, Bo Kyung A., Dharia, Neekesh V., Lin, Shan, Donovan, Katherine A., Chong, Shasha, Robichaud, Amanda, Conway, Amy, Hamze, Amanda, Ross, Linda, Alexe, Gabriela, Adane, Biniam, Nabet, Behnam, Ferguson, Fleur M., Stolte, Björn, Wang, Emily Jue, Sun, Jialin, Darzacq, Xavier, Piccioni, Federica, Gray, Nathanael S., Fischer, Eric S., Stegmaier, Kimberly
Publicado 2021

Discovery of a selective inhibitor of Doublecortin Like Kinase 1

por Ferguson, Fleur M., Nabet, Behnam, Raghavan, Srivatsan, Liu, Yan, Leggett, Alan L., Kuljanin, Miljan, Kalekar, Radha L., Yang, Annan, He, Shuning, Wang, Jinhua, Ng, Raymond W. S., Sulahian, Rita, Li, Lianbo, Poulin, Emily J., Huang, Ling, Koren, Jost, Dieguez-Martinez, Nora, Espinosa, Sergio, Zeng, Zhiyang, Corona, Cesear R., Vasta, James D., Ohi, Ryoma, Sim, Taebo, Kim, Nam Doo, Harshbarger, Wayne, Lizcano, Jose M., Robers, Matthew B., Muthaswamy, Senthil, Lin, Charles Y., Look, A. Thomas, Haigis, Kevin M., Mancias, Joseph D., Wolpin, Brian M., Aguirre, Andrew J., Hahn, William C., Westover, Kenneth D., Gray, Nathanael S.
Publicado 2020