The Cannabigerol Derivative VCE-003.2 Exerts Therapeutic Effects in 6-Hydroxydopamine-Lesioned Mice: Comparison with The Classic Dopaminergic Replacement Therapy

por Rodríguez-Carreiro, Santiago, Navarro, Elisa, Muñoz, Eduardo, Fernández-Ruiz, Javier
Publicado 2023

New Statement about NRF2 in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

por Lastres-Becker, Isabel, de Lago, Eva, Martínez, Ana, Fernández-Ruiz, Javier
Publicado 2022

Effects of a Sativex-Like Combination of Phytocannabinoids on Disease Progression in R6/2 Mice, an Experimental Model of Huntington’s Disease

por Valdeolivas, Sara, Sagredo, Onintza, Delgado, Mercedes, Pozo, Miguel A., Fernández-Ruiz, Javier
Publicado 2017

Development of An Oral Treatment with the PPAR-γ-Acting Cannabinoid VCE-003.2 Against the Inflammation-Driven Neuronal Deterioration in Experimental Parkinson’s Disease

por Burgaz, Sonia, García, Concepción, Gómez-Cañas, Maria, Muñoz, Eduardo, Fernández-Ruiz, Javier
Publicado 2019

Targeting Cannabinoid CB(2) Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

por Navarro, Gemma, Morales, Paula, Rodríguez-Cueto, Carmen, Fernández-Ruiz, Javier, Jagerovic, Nadine, Franco, Rafael
Publicado 2016

Neuroprotection with the Cannabidiol Quinone Derivative VCE-004.8 (EHP-101) against 6-Hydroxydopamine in Cell and Murine Models of Parkinson’s Disease

por Burgaz, Sonia, García, Concepción, Gómez-Cañas, María, Rolland, Alain, Muñoz, Eduardo, Fernández-Ruiz, Javier
Publicado 2021

Endocannabinoid System in Spinocerebellar Ataxia Type-3 and Other Autosomal-Dominant Cerebellar Ataxias: Potential Role in Pathogenesis and Expected Relevance as Neuroprotective Ta...

por Gómez-Ruiz, María, Rodríguez-Cueto, Carmen, Luna-Piñel, Eva, Hernández-Gálvez, Mariluz, Fernández-Ruiz, Javier
Publicado 2019

Pharmacokinetics of Sativex(®) in Dogs: Towards a Potential Cannabinoid-Based Therapy for Canine Disorders

por Fernández-Trapero, María, Pérez-Díaz, Carmen, Espejo-Porras, Francisco, de Lago, Eva, Fernández-Ruiz, Javier
Publicado 2020

Pharmacological Activation/Inhibition of the Cannabinoid System Affects Alcohol Withdrawal-Induced Neuronal Hypersensitivity to Excitotoxic Insults

por Rubio, Marina, Villain, Hélène, Docagne, Fabian, Roussel, Benoit D., Ramos, José Antonio, Vivien, Denis, Fernandez-Ruiz, Javier, Ali, Carine
Publicado 2011

Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments

por Satta, Valentina, Alonso, Cristina, Díez, Paula, Martín-Suárez, Soraya, Rubio, Marta, Encinas, Juan M., Fernández-Ruiz, Javier, Sagredo, Onintza
Publicado 2021

Inactivation of the CB(2) receptor accelerated the neuropathological deterioration in TDP‐43 transgenic mice, a model of amyotrophic lateral sclerosis

por Rodríguez‐Cueto, Carmen, Gómez‐Almería, Marta, García Toscano, Laura, Romero, Julián, Hillard, Cecilia J., de Lago, Eva, Fernández‐Ruiz, Javier
Publicado 2021

Upregulation of CB(2) receptors in reactive astrocytes in canine degenerative myelopathy, a disease model of amyotrophic lateral sclerosis

por Fernández-Trapero, María, Espejo-Porras, Francisco, Rodríguez-Cueto, Carmen, Coates, Joan R., Pérez-Díaz, Carmen, de Lago, Eva, Fernández-Ruiz, Javier
Publicado 2017

Altered striatal endocannabinoid signaling in a transgenic mouse model of spinocerebellar ataxia type-3

por Rodríguez-Cueto, Carmen, Hernández-Gálvez, Mariluz, Hillard, Cecilia J., Maciel, Patricia, Valdeolivas, Sara, Ramos, José A., Gómez-Ruiz, María, Fernández-Ruiz, Javier
Publicado 2017

Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB(2) Receptor

por Morales, Paula, Navarro, Gemma, Gómez‐Autet, Marc, Redondo, Laura, Fernández‐Ruiz, Javier, Pérez‐Benito, Laura, Cordomí, Arnau, Pardo, Leonardo, Franco, Rafael, Jagerovic, Nadine
Publicado 2020

Different Susceptibility to the Parkinson's Toxin MPTP in Mice Lacking the Redox Master Regulator Nrf2 or Its Target Gene Heme Oxygenase-1

por Innamorato, Nadia G., Jazwa, Agnieszka, Rojo, Ana I., García, Concepción, Fernández-Ruiz, Javier, Grochot–Przeczek, Anna, Stachurska, Anna, Jozkowicz, Alicja, Dulak, Jozef, Cuadrado, Antonio
Publicado 2010

Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice

por Santos-García, Irene, Rodríguez-Cueto, Carmen, Villegas, Patricia, Piscitelli, Fabiana, Lauritano, Anna, Shen, Che-Kun J., Di Marzo, Vincenzo, Fernández-Ruiz, Javier, de Lago, Eva
Publicado 2023

Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome

por Rubio, Marta, Valdeolivas, Sara, Piscitelli, Fabiana, Verde, Roberta, Satta, Valentina, Barroso, Eva, Montolio, Marisol, Aras, Luis Miguel, Di Marzo, Vincenzo, Sagredo, Onintza, Fernández‐Ruiz, Javier
Publicado 2016

BiP Heterozigosity Aggravates Pathological Deterioration in Experimental Amyotrophic Lateral Sclerosis

por Gómez-Almería, Marta, Burgaz, Sonia, Costas-Insua, Carlos, Rodríguez-Cueto, Carmen, Santos-García, Irene, Rodríguez-Crespo, Ignacio, García, Concepción, Guzmán, Manuel, de Lago, Eva, Fernández-Ruiz, Javier
Publicado 2021

Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment

por Martínez-González, Loreto, Rodríguez-Cueto, Carmen, Cabezudo, Diego, Bartolomé, Fernando, Andrés-Benito, Pol, Ferrer, Isidro, Gil, Carmen, Martín-Requero, Ángeles, Fernández-Ruiz, Javier, Martínez, Ana, de Lago, Eva
Publicado 2020

The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathwa...

por del Río, Carmen, Navarrete, Carmen, Collado, Juan A., Bellido, M. Luz, Gómez-Cañas, María, Pazos, M. Ruth, Fernández-Ruiz, Javier, Pollastro, Federica, Appendino, Giovanni, Calzado, Marco A., Cantarero, Irene, Muñoz, Eduardo
Publicado 2016