Role of Merlin/NF2 Inactivation in Tumor Biology

por Petrilli, Alejandra M., Fernández-Valle, Cristina
Publicado 2015

Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis

por Petrilli, Alejandra M., Bott, Marga, Fernández-Valle, Cristina
Publicado 2013

Stability of the tumor suppressor merlin depends on its ability to bind paxillin LD3 and associate with β1 integrin and actin at the plasma membrane

por Manetti, Maria Elisa, Geden, Sandra, Bott, Marga, Sparrow, Nicklaus, Lambert, Stephen, Fernandez-Valle, Cristina
Publicado 2012

Simultaneous Inhibition of PI3K and PAK in Preclinical Models of Neurofibromatosis Type 2-related Schwannomatosis

por Fernandez-Valle, Cristina, Nagel, Anna, Huegel, Julianne, Petrilli, Alejandra, Rosario, Rosa, Victoria, Berta, Hardin, Haley
Publicado 2023

WP1066 induces cell death in a schwannomatosis patient–derived schwannoma cell line

por Allaf, Abdulrahman, Victoria, Berta, Rosario, Rosa, Misztal, Carly, Humayun Gultekin, Sakir, Dinh, Christine T., Fernandez-Valle, Cristina
Publicado 2022

LIM Domain Kinases as Potential Therapeutic Targets for Neurofibromatosis Type 2

por Petrilli, Alejandra, Copik, Alicja, Posadas, Michelle, Chang, Long-Sheng, Welling, D. Bradley, Giovannini, Marco, Fernández-Valle, Cristina
Publicado 2013

CUDC907, a dual phosphoinositide-3 kinase/histone deacetylase inhibitor, promotes apoptosis of NF2 Schwannoma cells

por Huegel, Julianne, Dinh, Christine T., Martinelli, Maria, Bracho, Olena, Rosario, Rosa, Hardin, Haley, Estivill, Michael, Griswold, Anthony, Gultekin, Sakir, Liu, Xue-Zhong, Fernandez-Valle, Cristina
Publicado 2022

Understanding the Radiobiology of Vestibular Schwannomas to Overcome Radiation Resistance

por Thielhelm, Torin P., Goncalves, Stefania, Welford, Scott M., Mellon, Eric A., Cohen, Erin R., Nourbakhsh, Aida, Fernandez-Valle, Cristina, Telischi, Fred, Ivan, Michael E., Dinh, Christine T.
Publicado 2021

Peroxynitrite supports a metabolic reprogramming in merlin-deficient Schwann cells and promotes cell survival

por Pestoni, Jeanine C., Klingeman Plati, Stephani, Valdivia Camacho, Oliver D., Fuse, Marisa A., Onatunde, Maria, Sparrow, Nicklaus A., Karajannis, Matthias A., Fernández-Valle, Cristina, Franco, Maria Clara
Publicado 2019

Single Fraction and Hypofractionated Radiation Cause Cochlear Damage, Hearing Loss, and Reduced Viability of Merlin-Deficient Schwann Cells

por Dinh, Christine T., Chen, Si, Nourbakhsh, Aida, Padgett, Kyle, Johnson, Perry, Goncalves, Stefania, Bracho, Olena, Bas, Esperanza, Bohorquez, Jorge, Monje, Paula V., Fernandez-Valle, Cristina, Elsayyad, Nagy, Liu, Xuezhong, Welford, Scott M., Telischi, Fred
Publicado 2023

Tumor-Associated Macrophages in Vestibular Schwannoma and Relationship to Hearing

por Nisenbaum, Eric, Misztal, Carly, Szczupak, Mikhaylo, Thielhelm, Torin, Peña, Stefanie, Mei, Christine, Goncalves, Stefania, Bracho, Olena, Ma, Ruixuan, Ivan, Michael E., Morcos, Jacques, Telischi, Fred, Liu, Xue-Zhong, Fernandez-Valle, Cristina, Dinh, Christine T.
Publicado 2021

Ponatinib promotes a G(1) cell-cycle arrest of merlin/NF2-deficient human schwann cells

por Petrilli, Alejandra M, Garcia, Jeanine, Bott, Marga, Plati, Stephani Klingeman, Dinh, Christine T, Bracho, Olena R, Yan, Denise, Zou, Bing, Mittal, Rahul, Telischi, Fred F, Liu, Xue-Zhong, Chang, Long-Sheng, Bradley, D Welling, Copik, Alicja J, Fernández-Valle, Cristina
Publicado 2017

Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2

por Allaway, Robert, Angus, Steve P., Beauchamp, Roberta L., Blakeley, Jaishri O., Bott, Marga, Burns, Sarah S., Carlstedt, Annemarie, Chang, Long-Sheng, Chen, Xin, Clapp, D. Wade, Desouza, Patrick A., Erdin, Serkan, Fernandez-Valle, Cristina, Guinney, Justin, Gusella, James F., Haggarty, Stephen J., Johnson, Gary L., La Rosa, Salvatore, Morrison, Helen, Petrilli, Alejandra M., Plotkin, Scott R., Pratap, Abhishek, Ramesh, Vijaya, Sciaky, Noah, Stemmer-Rachamimov, Anat, Stuhlmiller, Tim J., Talkowski, Michael E., Welling, D. Bradley, Yates, Charles W., Zawistowski, Jon S., Zhao, Wen-Ning
Publicado 2018

Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK

por Chang, Long-Sheng, Oblinger, Janet L., Smith, Abbi E., Ferrer, Marc, Angus, Steven P., Hawley, Eric, Petrilli, Alejandra M., Beauchamp, Roberta L., Riecken, Lars Björn, Erdin, Serkan, Poi, Ming, Huang, Jie, Bessler, Waylan K., Zhang, Xiaohu, Guha, Rajarshi, Thomas, Craig, Burns, Sarah S., Gilbert, Thomas S. K., Jiang, Li, Li, Xiaohong, Lu, Qingbo, Yuan, Jin, He, Yongzheng, Dixon, Shelley A. H., Masters, Andrea, Jones, David R., Yates, Charles W., Haggarty, Stephen J., La Rosa, Salvatore, Welling, D. Bradley, Stemmer-Rachamimov, Anat O., Plotkin, Scott R., Gusella, James F., Guinney, Justin, Morrison, Helen, Ramesh, Vijaya, Fernandez-Valle, Cristina, Johnson, Gary L., Blakeley, Jaishri O., Clapp, D. Wade
Publicado 2021