Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

por Fernandes, Hugo J. R., Ryan, Brent J., Wade-Martins, Richard
Publicado 2016

Mitochondrial and Endoplasmic Reticulum Stress Trigger Triglyceride Accumulation in Models of Parkinson’s Disease Independent of Mutations in MAPT

por Fernandes, Hugo J. R., Kent, Josh P., Bruntraeger, Michaela, Bassett, Andrew R., Koulman, Albert, Metzakopian, Emmanouil, Snowden, Stuart G.
Publicado 2023

Development and Application of High-Throughput Single Cell Lipid Profiling: A Study of SNCA-A53T Human Dopamine Neurons

por Snowden, Stuart G., Fernandes, Hugo J.R., Kent, Josh, Foskolou, Stefanie, Tate, Peri, Field, Sarah F., Metzakopian, Emmanouil, Koulman, Albert
Publicado 2020

MicroExonator enables systematic discovery and quantification of microexons across mouse embryonic development

por Parada, Guillermo E., Munita, Roberto, Georgakopoulos-Soares, Ilias, Fernandes, Hugo J. R., Kedlian, Veronika R., Metzakopian, Emmanouil, Andres, Maria Estela, Miska, Eric A., Hemberg, Martin
Publicado 2021

Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease

por Vazquez-Arango, Pilar, Vowles, Jane, Browne, Cathy, Hartfield, Elizabeth, Fernandes, Hugo J. R., Mandefro, Berhan, Sareen, Dhruv, James, William, Wade-Martins, Richard, Cowley, Sally A., Murphy, Shona, O'Reilly, Dawn
Publicado 2016

CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death

por Pavlou, Sofia, Foskolou, Stefanie, Patikas, Nikolaos, Field, Sarah F., Papachristou, Evangelia K., Santos, Clive D’, Edwards, Abigail R., Kishore, Kamal, Ansari, Rizwan, Rajan, Sandeep S., Fernandes, Hugo J. R., Metzakopian, Emmanouil
Publicado 2023

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons

por Zambon, Federico, Cherubini, Marta, Fernandes, Hugo J R, Lang, Charmaine, Ryan, Brent J, Volpato, Viola, Bengoa-Vergniory, Nora, Vingill, Siv, Attar, Moustafa, Booth, Heather D E, Haenseler, Walther, Vowles, Jane, Bowden, Rory, Webber, Caleb, Cowley, Sally A, Wade-Martins, Richard
Publicado 2019

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

por Fernandes, Hugo J.R., Hartfield, Elizabeth M., Christian, Helen C., Emmanoulidou, Evangelia, Zheng, Ying, Booth, Heather, Bogetofte, Helle, Lang, Charmaine, Ryan, Brent J., Sardi, S. Pablo, Badger, Jennifer, Vowles, Jane, Evetts, Samuel, Tofaris, George K., Vekrellis, Kostas, Talbot, Kevin, Hu, Michele T., James, William, Cowley, Sally A., Wade-Martins, Richard
Publicado 2016

Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

por Siddiqi, Farah H., Menzies, Fiona M., Lopez, Ana, Stamatakou, Eleanna, Karabiyik, Cansu, Ureshino, Rodrigo, Ricketts, Thomas, Jimenez-Sanchez, Maria, Esteban, Miguel Angel, Lai, Liangxue, Tortorella, Micky D., Luo, Zhiwei, Liu, Hao, Metzakopian, Emmanouil, Fernandes, Hugo J. R., Bassett, Andrew, Karran, Eric, Miller, Bruce L., Fleming, Angeleen, Rubinsztein, David C.
Publicado 2019

Author Correction: Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

por Siddiqi, Farah H., Menzies, Fiona M., Lopez, Ana, Stamatakou, Eleanna, Karabiyik, Cansu, Ureshino, Rodrigo, Ricketts, Thomas, Jimenez-Sanchez, Maria, Esteban, Miguel Angel, Lai, Liangxue, Tortorella, Micky D., Luo, Zhiwei, Liu, Hao, Metzakopian, Emmanouil, Fernandes, Hugo J. R., Bassett, Andrew, Karran, Eric, Miller, Bruce L., Fleming, Angeleen, Rubinsztein, David C.
Publicado 2019