Glutamine Synthetase Drugability beyond Its Active Site: Exploring Oligomerization Interfaces and Pockets

por Moreira, Cátia, Ramos, Maria J., Fernandes, Pedro A.
Publicado 2016

Comparative evolutionary genomics of the HADH2 gene encoding Aβ-binding alcohol dehydrogenase/17β-hydroxysteroid dehydrogenase type 10 (ABAD/HSD10)

por Marques, Alexandra T, Antunes, Agostinho, Fernandes, Pedro A, Ramos, Maria J
Publicado 2006

Role of Enzyme and Active Site Conformational Dynamics in the Catalysis by α-Amylase Explored with QM/MM Molecular Dynamics

por Neves, Rui P. P., Fernandes, Pedro A., Ramos, Maria J.
Publicado 2022

Engineering DszC Mutants from Transition State Macrodipole Considerations and Evolutionary Sequence Analysis

por Neves, Rui P. P., Ramos, Maria J., Fernandes, Pedro A.
Publicado 2022

Rational Engineering of (S)-Norcoclaurine Synthase for Efficient Benzylisoquinoline Alkaloids Biosynthesis

por De Sousa, João P. M., Oliveira, Nuno C. S. A., Fernandes, Pedro A.
Publicado 2023

The importance of intramolecular hydrogen bonds on the translocation of the small drug piracetam through a lipid bilayer

por Coimbra, João T. S., Feghali, Ralph, Ribeiro, Rui P., Ramos, Maria J., Fernandes, Pedro A.
Publicado 2021

Membrane partition of bis-(3-hydroxy-4-pyridinonato) zinc(ii) complexes revealed by molecular dynamics simulations

por Coimbra, João T. S., Brás, Natércia F., Fernandes, Pedro A., Rangel, Maria, Ramos, Maria J.
Publicado 2018

Unraveling the Reaction Mechanism of Russell’s Viper Venom Factor X Activator: A Paradigm for the Reactivity of Zinc Metalloproteinases?

por Castro-Amorim, Juliana, Oliveira, Ana, Mukherjee, Ashis K., Ramos, Maria J., Fernandes, Pedro A.
Publicado 2023

Beyond the TPP(+) “gold standard”: a new generation mitochondrial delivery vector based on extended PN frameworks

por Ong, How Chee, Coimbra, João T. S., Ramos, Maria J., Xing, Bengang, Fernandes, Pedro A., García, Felipe
Publicado 2023

How the Destabilization of a Reaction Intermediate Affects Enzymatic Efficiency: The Case of Human Transketolase

por Prejanò, Mario, Medina, Fabiola E., Ramos, Maria J., Russo, Nino, Fernandes, Pedro A., Marino, Tiziana
Publicado 2020

Possible Role of Pineal and Extra-Pineal Melatonin in Surveillance, Immunity, and First-Line Defense

por Markus, Regina P., Sousa, Kassiano S., da Silveira Cruz-Machado, Sanseray, Fernandes, Pedro A., Ferreira, Zulma S.
Publicado 2021

Evolution of Acridines and Xanthenes as a Core Structure for the Development of Antileishmanial Agents

por Silva, Carlos F. M., Pinto, Diana C. G. A., Fernandes, Pedro A., Silva, Artur M. S.
Publicado 2022

β-Adrenoceptors Trigger Melatonin Synthesis in Phagocytes

por Pires-Lapa, Marco A., Carvalho-Sousa, Claudia E., Cecon, Erika, Fernandes, Pedro A., Markus, Regina P.
Publicado 2018

Chromeno[3,4-b]xanthones as First-in-Class AChE and Aβ Aggregation Dual-Inhibitors

por Malafaia, Daniela, Oliveira, Ana, Fernandes, Pedro A., Ramos, Maria J., Albuquerque, Hélio M. T., Silva, Artur M. S.
Publicado 2021

Alkyl vs. aryl modifications: a comparative study on modular modifications of triphenylphosphonium mitochondrial vectors

por Ong, How Chee, Coimbra, João T. S., Kwek, Germain, Ramos, Maria J., Xing, Bengang, Fernandes, Pedro A., García, Felipe
Publicado 2021

The chemistry of snake venom and its medicinal potential

por Oliveira, Ana L., Viegas, Matilde F., da Silva, Saulo L., Soares, Andreimar M., Ramos, Maria J., Fernandes, Pedro A.
Publicado 2022

The Antidiabetic Effect of Grape Pomace Polysaccharide-Polyphenol Complexes

por Campos, Filipa, Peixoto, Andreia F., Fernandes, Pedro A. R., Coimbra, Manuel A., Mateus, Nuno, de Freitas, Victor, Fernandes, Iva, Fernandes, Ana
Publicado 2021

Catalytically Active Snake Venom PLA(2) Enzymes: An Overview of Its Elusive Mechanisms of Reaction: Miniperspective

por Castro-Amorim, Juliana, Novo de Oliveira, Ana, Da Silva, Saulo Luís, Soares, Andreimar M., Mukherjee, Ashis K., Ramos, Maria João, Fernandes, Pedro A.
Publicado 2023

Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2

por Merski, Matthew, Moreira, Cátia, Abreu, Rui MV, Ramos, Maria João, Fernandes, Pedro A, Martins, L Miguel, Pereira, Pedro José Barbosa, Macedo-Ribeiro, Sandra
Publicado 2017

Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program

por da Silveira Cruz-Machado, Sanseray, Tamura, Eduardo K., Carvalho-Sousa, Claudia E., Rocha, Vanderlei Amadeu, Pinato, Luciana, Fernandes, Pedro A. C., Markus, Regina P.
Publicado 2017