Bruton’s tyrosine kinase inhibition increases BCL-2 dependence and enhances sensitivity to venetoclax in chronic lymphocytic leukemia

por Deng, Jing, Isik, Elif, Fernandes, Stacey M., Brown, Jennifer R., Letai, Anthony, Davids, Matthew S.
Publicado 2017

Multi-Factor Clustering Incorporating Cell Motility Predicts T Cell Expansion Potential

por Lee, Joanne H., Shao, Shuai, Kim, Michelle, Fernandes, Stacey M., Brown, Jennifer R., Kam, Lance C.
Publicado 2021

4321 Personalization of T cell production for cellular immunotherapy

por Yuan, Dennis Jinglun, Shao, Shuai, Lee, Joanne H, Fernandes, Stacey M, Brown, Jennifer R, Kam, Lance C
Publicado 2020

IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3K(δ) inhibitor idelalisib

por Sandova, Veronika, Pavlasova, Gabriela Mladonicka, Seda, Vaclav, Cerna, Katerina Amruz, Sharma, Sonali, Palusova, Veronika, Brychtova, Yvona, Pospisilova, Sarka, Fernandes, Stacey M., Panovska, Anna, Doubek, Michael, Davids, Matthew S., Brown, Jennifer R., Mayer, Jiri, Mraz, Marek
Publicado 2021

Mechanism of EBV inducing anti-tumour immunity and its therapeutic use

por Choi, Il-Kyu, Wang, Zhe, Ke, Qiang, Hong, Min, Paul, Dereck W., Fernandes, Stacey M., Hu, Zhuting, Stevens, Jonathan, Guleria, Indira, Kim, Hye-Jung, Cantor, Harvey, Wucherpfennig, Kai W., Brown, Jennifer R., Ritz, Jerome, Zhang, Baochun
Publicado 2020

Circulating Th17 T cells at treatment onset predict autoimmune toxicity of PI3Kδ inhibitors

por Gadi, Deepti, Martindale, Stephen P., Chiu, Pui Yan, Khalsa, Jasneet, Chen, Pei-Hsuan, Fernandes, Stacey M., Wang, Zixu, Tyekucheva, Svitlana, Machado, John-Hanson, Fisher, David C., Armand, Philippe, Davids, Matthew S., Rodig, Scott, Sherry, Barbara, Brown, Jennifer R.
Publicado 2023

A T Cell Inflammatory Phenotype is Associated with Autoimmune Toxicity of the PI3K Inhibitor Duvelisib in Chronic Lymphocytic Leukemia

por Gadi, Deepti, Griffith, Alec, Tyekucheva, Svitlana, Wang, Zixu, Rai, Vanessa, Vartanov, Alexander, Thrash, Emily, Fernandes, Stacey M, Lehmberg, Timothy Z., Lee, Brandon, Martindale, Stephen P, Machado, John-Hanson, Odejide, Oreofe, Armand, Philippe, Fisher, David C., Arnason, Jon, Davids, Matthew S., Lederer, James A, Brown, Jennifer R.
Publicado 2022

S142: FOXO1-RICTOR AXIS INDUCES ADAPTIVE INCREASE IN AKT ACTIVITY DURING BCR INHIBITOR THERAPY IN CLL: IMPLICATIONS FOR COMBINATION THERAPY

por Ondrisova, Laura, Seda, Vaclav, Hoferkova, Eva, Chiodin, Giorgia, Hlavac, Krystof, Kostalova, Lenka, Filip, Daniel, Faria Zeni, Pedro, Panovska, Anna, Plevova, Karla, Pospisilova, Sarka, Simkovic, Martin, Vrbacky, Filip, Lysak, Daniel, Fernandes, Stacey M., Davids, Matthew S., Maiques-Diaz, Alba, Charalampopoulou, Stella, Martin-Subero, Jose I, Brown, Jennifer R, Doubek, Michael, Forconi, Francesco, Mayer, Jiri, Mraz, Marek
Publicado 2023

Pirtobrutinib targets BTK C481S in ibrutinib-resistant CLL but second-site BTK mutations lead to resistance

por Naeem, Aishath, Utro, Filippo, Wang, Qing, Cha, Justin, Vihinen, Mauno, Martindale, Stephen, Zhou, Yinglu, Ren, Yue, Tyekucheva, Svitlana, Kim, Annette S., Fernandes, Stacey M., Saksena, Gordon, Rhrissorrakrai, Kahn, Levovitz, Chaya, Danysh, Brian P., Slowik, Kara, Jacobs, Raquel A., Davids, Matthew S., Lederer, James A., Zain, Rula, Smith, C. I. Edvard, Leshchiner, Ignaty, Parida, Laxmi, Getz, Gad, Brown, Jennifer R.
Publicado 2022

Characterization of selective and potent PI3Kδ inhibitor (PI3KD-IN-015) for B-Cell malignances

por Liu, Xiaochuan, Wang, Aoli, Liang, Xiaofei, Chen, Cheng, Liu, Juanjuan, Zhao, Zheng, Wu, Hong, Deng, Yuanxin, Wang, Li, Wang, Beilei, Wu, Jiaxin, Liu, Feiyang, Fernandes, Stacey M., Adamia, Sophia, Stone, Richard M., Galinsky, Ilene A., Brown, Jennifer R., Griffin, James D., Zhang, Shanchun, Loh, Teckpeng, Zhang, Xin, Wang, Wenchao, Weisberg, Ellen L., Liu, Jing, Liu, Qingsong
Publicado 2016

Simultaneous inhibition of Vps34 kinase would enhance PI3Kδ inhibitor cytotoxicity in the B-cell malignancies

por Liu, Xiaochuan, Wang, Aoli, Liang, Xiaofei, Liu, Juanjuan, Zou, Fengming, Chen, Cheng, Zhao, Zheng, Deng, Yuanxin, Wu, Hong, Qi, Ziping, Wang, Beilei, Wang, Li, Liu, Feiyang, Xu, Yunhe, Wang, Wenchao, Fernandes, Stacey M., Stone, Richard M., Galinsky, Ilene A., Brown, Jennifer R., Loh, Teckpeng, Griffin, James. D., Zhang, Shanchun, Weisberg, Ellen L., Zhang, Xin, Liu, Jing, Liu, Qingsong
Publicado 2016

Rare Germline Variants in ATM Are Associated with Chronic Lymphocytic Leukemia

por Tiao, Grace, Improgo, Ma. Reina, Kasar, Siddha, Poh, Weijie, Kamburov, Atanas, Landau, Dan-Avi, Tausch, Eugen, Taylor-Weiner, Amaro, Cibulskis, Carrie, Bahl, Samira, Fernandes, Stacey M., Hoang, Kevin, Rheinbay, Esther, Kim, Haesook T., Bahlo, Jasmin, Robrecht, Sandra, Fischer, Kirsten, Hallek, Michael, Gabriel, Stacey, Lander, Eric S., Stilgenbauer, Stephan, Wu, Catherine J., Kiezun, Adam, Getz, Gad, Brown, Jennifer R.
Publicado 2017