High Temperature Unfolding Simulations of the TRPZ1 Peptide

por Settanni, Giovanni, Fersht, Alan R.
Publicado 2008

Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA

por Veprintsev, Dmitry B., Fersht, Alan R.
Publicado 2008

Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53

por Rajagopalan, Sridharan, Huang, Fang, Fersht, Alan R.
Publicado 2011

Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2

por Teufel, Daniel P., Bycroft, Mark, Fersht, Alan R.
Publicado 2009

Combination of Markov State Models and Kinetic Networks for the Analysis of Molecular Dynamics Simulations of Peptide Folding

por Radford, Isolde H., Fersht, Alan R., Settanni, Giovanni
Publicado 2011

Long-Range Modulation of Chain Motions within the Intrinsically Disordered Transactivation Domain of Tumor Suppressor p53

por Lum, Jenifer K., Neuweiler, Hannes, Fersht, Alan R.
Publicado 2011

Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms

por Rajagopalan, Sridharan, Sade, Robert S., Townsley, Fiona M., Fersht, Alan R.
Publicado 2010

Stability of p53 Homologs

por Brandt, Tobias, Kaar, Joel L., Fersht, Alan R., Veprintsev, Dmitry B.
Publicado 2012

14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers

por Rajagopalan, Sridharan, Jaulent, Agnes M., Wells, Mark, Veprintsev, Dmitry B., Fersht, Alan R.
Publicado 2008

Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core

por Khoo, Kian Hoe, Joerger, Andreas C., Freund, Stefan M.V., Fersht, Alan R.
Publicado 2009

Interaction between the Transactivation Domain of p53 and PC4 Exemplifies Acidic Activation Domains as Single-stranded DNA Mimics

por Rajagopalan, Sridharan, Andreeva, Antonina, Teufel, Daniel P., Freund, Stefan M., Fersht, Alan R.
Publicado 2009

Engineering a two-helix bundle protein for folding studies

por Dodson, Charlotte A., Ferguson, Neil, Rutherford, Trevor J., Johnson, Christopher M., Fersht, Alan R.
Publicado 2010

Small molecule induced reactivation of mutant p53 in cancer cells

por Liu, Xiangrui, Wilcken, Rainer, Joerger, Andreas C., Chuckowree, Irina S., Amin, Jahangir, Spencer, John, Fersht, Alan R.
Publicado 2013

Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53

por Wong, Tuck Seng, Rajagopalan, Sridharan, Townsley, Fiona M., Freund, Stefan M., Petrovich, Miriana, Loakes, David, Fersht, Alan R.
Publicado 2009

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

por Wilcken, Rainer, Liu, Xiangrui, Zimmermann, Markus O., Rutherford, Trevor J., Fersht, Alan R., Joerger, Andreas C., Boeckler, Frank M.
Publicado 2012

Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere

por Wilcken, Rainer, Zimmermann, Markus O., Bauer, Matthias R., Rutherford, Trevor J., Fersht, Alan R., Joerger, Andreas C., Boeckler, Frank M.
Publicado 2015

PFD: a database for the investigation of protein folding kinetics and stability

por Fulton, Kate F., Devlin, Glyn L., Jodun, Rachel A., Silvestri, Linda, Bottomley, Stephen P., Fersht, Alan R., Buckle, Ashley M.
Publicado 2005

Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53

por Wong, Tuck Seng, Rajagopalan, Sridharan, Freund, Stefan M., Rutherford, Trevor J., Andreeva, Antonina, Townsley, Fiona M., Petrovich, Miriana, Fersht, Alan R.
Publicado 2009

Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer

por Natan, Eviatar, Baloglu, Cetin, Pagel, Kevin, Freund, Stefan M.V., Morgner, Nina, Robinson, Carol V., Fersht, Alan R., Joerger, Andreas C.
Publicado 2011

Deconvoluting Protein (Un)folding Structural Ensembles Using X-Ray Scattering, Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation

por Nasedkin, Alexandr, Marcellini, Moreno, Religa, Tomasz L., Freund, Stefan M., Menzel, Andreas, Fersht, Alan R., Jemth, Per, van der Spoel, David, Davidsson, Jan
Publicado 2015