BCL-2 AND IAP Proteins As Potential Drug Targets

por Fesik, Stephen W.
Publicado 2001

Fragment-Based Screening of the Bromodomain of ATAD2

por Harner, Mary J., Chauder, Brian A., Phan, Jason, Fesik, Stephen W.
Publicado 2014

Targeting WDR5: A WINning Anti-Cancer Strategy?

por Aho, Erin R, Weissmiller, April M, Fesik, Stephen W, Tansey, William P
Publicado 2019

Targeting MYC through WDR5

por Thomas, Lance R., Adams, Clare M., Fesik, Stephen W., Eischen, Christine M., Tansey, William P.
Publicado 2020

siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

por Lin, Xiaoyu, Ruan, Xiaoan, Anderson, Mark G., McDowell, Jeffrey A., Kroeger, Paul E., Fesik, Stephen W., Shen, Yu
Publicado 2005

Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance

por Thomas, Lance R., Adams, Clare M., Wang, Jing, Weissmiller, April M., Creighton, Joy, Lorey, Shelly L., Liu, Qi, Fesik, Stephen W., Eischen, Christine M., Tansey, William P.
Publicado 2019

Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A

por Frank, Andreas O., Vangamudi, Bhavatarini, Feldkamp, Michael D., Souza-Fagundes, Elaine M., Luzwick, Jessica W., Cortez, David, Olejniczak, Edward T., Waterson, Alex G., Rossanese, Olivia W., Chazin, Walter J., Fesik, Stephen W.
Publicado 2014

WIN site inhibition disrupts a subset of WDR5 function

por Siladi, Andrew J., Wang, Jing, Florian, Andrea C., Thomas, Lance R., Creighton, Joy H., Matlock, Brittany K., Flaherty, David K., Lorey, Shelly L., Howard, Gregory C., Fesik, Stephen W., Weissmiller, April M., Liu, Qi, Tansey, William P.
Publicado 2022

WDR5 is a conserved regulator of protein synthesis gene expression

por Bryan, Audra F, Wang, Jing, Howard, Gregory C, Guarnaccia, Alissa D, Woodley, Chase M, Aho, Erin R, Rellinger, Eric J, Matlock, Brittany K, Flaherty, David K, Lorey, Shelly L, Chung, Dai H, Fesik, Stephen W, Liu, Qi, Weissmiller, April M, Tansey, William P
Publicado 2020

Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells

por Florian, Andrea C, Woodley, Chase M, Wang, Jing, Grieb, Brian C, Slota, Macey J, Guerrazzi, Kiana, Hsu, Chih-Yuan, Matlock, Brittany K, Flaherty, David K, Lorey, Shelly L, Fesik, Stephen W, Howard, Gregory C, Liu, Qi, Weissmiller, April M, Tansey, William P
Publicado 2022

Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

por Howard, Gregory C., Wang, Jing, Rose, Kristie Lindsey, Patel, Purvi, Tsui, Tina, Florian, Andrea C., Lorey, Shelly L., Grieb, Brian C., Smith, Brianna N., Slota, Macey J., Reynolds, Elizabeth M., Goswami, Soumita, Savona, Michael R., Lee, Taekyu, Fesik, Stephen W., Liu, Qi, Tansey, William P.
Publicado 2023

Impact of WIN site inhibitor on the WDR5 interactome

por Guarnaccia, Alissa D., Rose, Kristie L., Wang, Jing, Zhao, Bin, Popay, Tessa M., Wang, Christina E., Guerrazzi, Kiana, Hill, Salisha, Woodley, Chase M., Hansen, Tyler J., Lorey, Shelly L., Shaw, J. Grace, Payne, William G., Weissmiller, April M., Olejniczak, Edward T., Fesik, Stephen W., Liu, Qi, Tansey, William P.
Publicado 2021

Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models

por Teuscher, Kevin B., Chowdhury, Somenath, Meyers, Kenneth M., Tian, Jianhua, Sai, Jiqing, Van Meveren, Mayme, South, Taylor M., Sensintaffar, John L., Rietz, Tyson A., Goswami, Soumita, Wang, Jing, Grieb, Brian C., Lorey, Shelly L., Howard, Gregory C., Liu, Qi, Moore, William J., Stott, Gordon M., Tansey, William P., Lee, Taekyu, Fesik, Stephen W.
Publicado 2022

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

por Aho, Erin R., Wang, Jing, Gogliotti, Rocco D., Howard, Gregory C., Phan, Jason, Acharya, Pankaj, Macdonald, Jonathan D., Cheng, Ken, Lorey, Shelly L., Lu, Bin, Wenzel, Sabine, Foshage, Audra M., Alvarado, Joseph, Wang, Feng, Shaw, J. Grace, Zhao, Bin, Weissmiller, April M., Thomas, Lance R., Vakoc, Christopher R., Hall, Matthew D., Hiebert, Scott W., Liu, Qi, Stauffer, Shaun R., Fesik, Stephen W., Tansey, William P.
Publicado 2019

Drugging an undruggable pocket on KRAS

por Kessler, Dirk, Gmachl, Michael, Mantoulidis, Andreas, Martin, Laetitia J., Zoephel, Andreas, Mayer, Moriz, Gollner, Andreas, Covini, David, Fischer, Silke, Gerstberger, Thomas, Gmaschitz, Teresa, Goodwin, Craig, Greb, Peter, Häring, Daniela, Hela, Wolfgang, Hoffmann, Johann, Karolyi-Oezguer, Jale, Knesl, Petr, Kornigg, Stefan, Koegl, Manfred, Kousek, Roland, Lamarre, Lyne, Moser, Franziska, Munico-Martinez, Silvia, Peinsipp, Christoph, Phan, Jason, Rinnenthal, Jörg, Sai, Jiqing, Salamon, Christian, Scherbantin, Yvonne, Schipany, Katharina, Schnitzer, Renate, Schrenk, Andreas, Sharps, Bernadette, Siszler, Gabriella, Sun, Qi, Waterson, Alex, Wolkerstorfer, Bernhard, Zeeb, Markus, Pearson, Mark, Fesik, Stephen W., McConnell, Darryl B.
Publicado 2019

Reply to Tran et al.: Dimeric KRAS protein–protein interaction stabilizers

por Kessler, Dirk, Gollner, Andreas, Gmachl, Michael, Mantoulidis, Andreas, Martin, Laetitia J., Zoephel, Andreas, Mayer, Moriz, Covini, David, Fischer, Silke, Gerstberger, Thomas, Gmaschitz, Teresa, Goodwin, Craig, Greb, Peter, Häring, Daniela, Hela, Wolfgang, Hoffmann, Johann, Karolyi-Oezguer, Jale, Knesl, Petr, Kornigg, Stefan, Koegl, Manfred, Kousek, Roland, Lamarre, Lyne, Moser, Franziska, Munico-Martinez, Silvia, Peinsipp, Christoph, Phan, Jason, Rinnenthal, Jörg, Sai, Jiqing, Salamon, Christian, Scherbantin, Yvonne, Schipany, Katharina, Schnitzer, Renate, Schrenk, Andreas, Sharps, Bernadette, Siszler, Gabriella, Sun, Qi, Waterson, Alex, Wolkerstorfer, Bernhard, Zeeb, Markus, Pearson, Mark, Fesik, Stephen W., McConnell, Darryl B.
Publicado 2020