Inter-species association mapping links splice site evolution to METTL16 and SNRNP27K

por Parker, Matthew T, Fica, Sebastian M, Barton, Geoffrey J, Simpson, Gordon G
Publicado 2023

Structural basis for conformational equilibrium of the catalytic spliceosome

por Wilkinson, Max E., Fica, Sebastian M., Galej, Wojciech P., Nagai, Kiyoshi
Publicado 2021

Evidence for a group II intron-like catalytic triplex in the spliceosome

por Fica, Sebastian M., Mefford, Melissa A., Piccirilli, Joseph A., Staley, Jonathan P.
Publicado 2014

CryoEM structure of the spliceosome immediately after branching

por Galej, Wojciech P., Wilkinson, Max E., Fica, Sebastian M., Oubridge, Chris, Newman, Andrew J., Nagai, Kiyoshi
Publicado 2016

CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feast

por Nguyen, Thi Hoang Duong, Galej, Wojciech P, Fica, Sebastian M, Lin, Pei-Chun, Newman, Andrew J, Nagai, Kiyoshi
Publicado 2016

Structure of a spliceosome remodelled for exon ligation

por Fica, Sebastian M., Oubridge, Chris, Galej, Wojciech P., Wilkinson, Max E., Bai, Xiao-Chen, Newman, Andrew J., Nagai, Kiyoshi
Publicado 2017

RNA catalyzes nuclear pre-mRNA splicing

por Fica, Sebastian M., Tuttle, Nicole, Novak, Thaddeus, Li, Nan-Sheng, Lu, Jun, Koodathingal, Prakash, Dai, Qing, Staley, Jonathan P., Piccirilli, Joseph A.
Publicado 2013

A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation

por Schellenberg, Matthew J., Wu, Tao, Ritchie, Dustin B., Fica, Sebastian, Staley, Jonathan P., Atta, Karim A., LaPointe, Paul, MacMillan, Andrew M.
Publicado 2013

psiCLIP reveals dynamic RNA binding by DEAH-box helicases before and after exon ligation

por Strittmatter, Lisa M., Capitanchik, Charlotte, Newman, Andrew J., Hallegger, Martina, Norman, Christine M., Fica, Sebastian M., Oubridge, Chris, Luscombe, Nicholas M., Ule, Jernej, Nagai, Kiyoshi
Publicado 2021

m(6)A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice site

por Parker, Matthew T, Soanes, Beth K, Kusakina, Jelena, Larrieu, Antoine, Knop, Katarzyna, Joy, Nisha, Breidenbach, Friedrich, Sherwood, Anna V, Barton, Geoffrey J, Fica, Sebastian M, Davies, Brendan H, Simpson, Gordon G
Publicado 2022