Myelination and mTOR

por Figlia, Gianluca, Gerber, Daniel, Suter, Ueli
Publicado 2017

Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system

por Figlia, Gianluca, Norrmén, Camilla, Pereira, Jorge A, Gerber, Daniel, Suter, Ueli
Publicado 2017

mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation

por Norrmén, Camilla, Figlia, Gianluca, Pfistner, Patrick, Pereira, Jorge A., Bachofner, Sven, Suter, Ueli
Publicado 2018

Ral GTPases in Schwann cells promote radial axonal sorting in the peripheral nervous system

por Ommer, Andrea, Figlia, Gianluca, Pereira, Jorge A., Datwyler, Anna Lena, Gerber, Joanne, DeGeer, Jonathan, Lalli, Giovanna, Suter, Ueli
Publicado 2019

Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition

por Figlia, Gianluca, Müller, Sandra, Hagenston, Anna M., Kleber, Susanne, Roiuk, Mykola, Quast, Jan-Philipp, ten Bosch, Nora, Carvajal Ibañez, Damian, Mauceri, Daniela, Martin-Villalba, Ana, Teleman, Aurelio A.
Publicado 2022

Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor

por Nicastro, Raffaele, Brohée, Laura, Alba, Josephine, Nüchel, Julian, Figlia, Gianluca, Kipschull, Stefanie, Gollwitzer, Peter, Romero-Pozuelo, Jesus, Fernandes, Stephanie A., Lamprakis, Andreas, Vanni, Stefano, Teleman, Aurelio A., De Virgilio, Claudio, Demetriades, Constantinos
Publicado 2023

De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination

por Montani, Laura, Pereira, Jorge A., Norrmén, Camilla, Pohl, Hartmut B.F., Tinelli, Elisa, Trötzmüller, Martin, Figlia, Gianluca, Dimas, Penelope, von Niederhäusern, Belinda, Schwager, Rachel, Jessberger, Sebastian, Semenkovich, Clay F., Köfeler, Harald C., Suter, Ueli
Publicado 2018

Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle

por Carvajal Ibañez, Damian, Skabkin, Maxim, Hooli, Jooa, Cerrizuela, Santiago, Göpferich, Manuel, Jolly, Adrien, Volk, Katrin, Zumwinkel, Marc, Bertolini, Matilde, Figlia, Gianluca, Höfer, Thomas, Kramer, Guenter, Anders, Simon, Teleman, Aurelio A, Marciniak‐Czochra, Anna, Martin‐Villalba, Ana
Publicado 2023

Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function

por Gerber, Daniel, Ghidinelli, Monica, Tinelli, Elisa, Somandin, Christian, Gerber, Joanne, Pereira, Jorge A, Ommer, Andrea, Figlia, Gianluca, Miehe, Michaela, Nägeli, Lukas G, Suter, Vanessa, Tadini, Valentina, Sidiropoulos, Páris NM, Wessig, Carsten, Toyka, Klaus V, Suter, Ueli
Publicado 2019

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

por Prentzell, Mirja Tamara, Rehbein, Ulrike, Cadena Sandoval, Marti, De Meulemeester, Ann-Sofie, Baumeister, Ralf, Brohée, Laura, Berdel, Bianca, Bockwoldt, Mathias, Carroll, Bernadette, Chowdhury, Suvagata Roy, von Deimling, Andreas, Demetriades, Constantinos, Figlia, Gianluca, de Araujo, Mariana Eca Guimaraes, Heberle, Alexander M., Heiland, Ines, Holzwarth, Birgit, Huber, Lukas A., Jaworski, Jacek, Kedra, Magdalena, Kern, Katharina, Kopach, Andrii, Korolchuk, Viktor I., van 't Land-Kuper, Ineke, Macias, Matylda, Nellist, Mark, Palm, Wilhelm, Pusch, Stefan, Ramos Pittol, Jose Miguel, Reil, Michèle, Reintjes, Anja, Reuter, Friederike, Sampson, Julian R., Scheldeman, Chloë, Siekierska, Aleksandra, Stefan, Eduard, Teleman, Aurelio A., Thomas, Laura E., Torres-Quesada, Omar, Trump, Saskia, West, Hannah D., de Witte, Peter, Woltering, Sandra, Yordanov, Teodor E., Zmorzynska, Justyna, Opitz, Christiane A., Thedieck, Kathrin
Publicado 2021