Bromodomain and Extra-Terminal Protein Inhibitors: Biologic Insights and Therapeutic Potential in Pediatric Brain Tumors

por Groves, Andrew, Clymer, Jessica, Filbin, Mariella G.
Publicado 2022

DIPG-39. New preclinical models for Diffuse Midline Glioma

por Klenner, Marbod, Freidel, Pia, Filbin, Mariella G, Beck, Alexander
Publicado 2022

Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances.

por Hwang, Eugene I., Hanson, Derek, Filbin, Mariella G., Mack, Stephen C.
Publicado 2023

METB-03. THE DISTINCT GENOMICS OF HIGH-GRADE INFANT GLIOMAS AMONG PEDIATRIC GLIOMAS HARBORING RECEPTOR TYROSINE KINASE FUSIONS

por de Biagi-Junior, Carlos A O, Eder, Sebastian K, LaBelle, Jenna, Filbin, Mariella G
Publicado 2023

Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma

por Lin, Grant L., Nagaraja, Surya, Filbin, Mariella G., Suvà, Mario L., Vogel, Hannes, Monje, Michelle
Publicado 2018

MEDB-82. Exploring cell-cell communication networks in medulloblastoma using single-cell genomics

por Gabler, Lisa, Gojo, Johannes, Smith, Kyle S, Bihannic, Laure, Filbin, Mariella G, Northcott, Paul A, Berger, Walter, Hovestadt, Volker
Publicado 2022

HGG-07. OVEREXPRESSION OF A PLAG-FAMILY TRANSCRIPTION FACTOR DURING MURINE BRAIN DEVELOPMENT CAUSES BRAIN TUMOR FORMATION

por Vaillant, Jan, Wittmann, Andrea, Keck, Michaela-Kristina, Rozowsky, Jacob S, Filbin, Mariella G, Pfister, Stefan M, Jones, David T W, Kutscher, Lena M
Publicado 2023

A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4

por Williams, Erik A., Brastianos, Priscilla K., Wakimoto, Hiroaki, Zolal, Amir, Filbin, Mariella G., Cahill, Daniel P., Santagata, Sandro, Juratli, Tareq A.
Publicado 2023

DIPG-28. IDENTIFICATION AND TARGETING OF METABOLIC VULNERABILITIES IN COMBINATION WITH PDGFRA-INHIBITION IN DIFFUSE MIDLINE GLIOMA

por Neyazi, Sina, Gowda, Pruthvi S, Trissal, Maria, Fonticella, Jay-Miguel, Portero, Erika P, Haley-Read, John-Paul, Anderson, Emily P, Danial, Nika N, Filbin, Mariella G
Publicado 2023

Infiltrative gliomas of the thalamus in children: the role of surgery in the era of H3 K27M mutant midline gliomas

por Dorfer, Christian, Czech, Thomas, Gojo, Johannes, Hosmann, Arthur, Peyrl, Andreas, Azizi, Amedeo A., Kasprian, Gregor, Dieckmann, Karin, Filbin, Mariella G., Haberler, Christine, Roessler, Karl, Slavc, Irene
Publicado 2020

HGG-53. PROJECT HOPE: “PEDIATRIC AND AYA HIGH-GRADE GLIOMA OMICS PROJECT”- A LONGITUDINAL MOLECULAR LANDSCAPE OF HIGH-GRADE GLIOMAS RESOLVED AT SINGLE-CELL LEVEL

por Hack, Olivia A, Babikir, Husam, Jiang, Li, Shamardani, Karin, Liu, Ilon, Shaw, McKenzie, Cunliffe-Koehler, Kennedy, Resnick, Adam, Prados, Michael, Monje, Michelle, Diaz, Aaron, Filbin, Mariella G
Publicado 2020

IMMU-08. MICROENVIRONMENT MODULATION BY TIM-3 BLOCKADE IMPROVES THE OUTCOME OF PRECLINICAL DIPG MODELS

por Ausejo-Mauleon, Iker, Labiano, Sara, Laspidea, Virginia, Garcia-Moure, Marc, de la Nava, Daniel, Puigdelloses, Montserrat, Becher, Oren J, Jiang, Li, Filbin, Mariella G, Pastor, Fernando, Alonso, Marta M
Publicado 2021

Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways

por Pun, Matthew, Pratt, Drew, Nano, Patricia R., Joshi, Piyush K., Jiang, Li, Englinger, Bernhard, Rao, Arvind, Cieslik, Marcin, Chinnaiyan, Arul M., Aldape, Kenneth, Pfister, Stefan, Filbin, Mariella G., Bhaduri, Aparna, Venneti, Sriram
Publicado 2023

EPEN-12. COMPARING CELLULAR HIERARCHIES AND SPATIAL ARCHITECTURE ACROSS MOLECULAR SUBGROUPS OF SUPRATENTORIAL EPENDYMOMAS

por Jeong, Daeun, Maass, Kendra K, Ghasemi, David R, Englinger, Bernhard, Jiang, Li, Nascimento, Andrezza, Hack, Olivia A, Shaw, McKenzie L, Pfister, Stefan M, Kool, Marcel, Gojo, Johannes, Pajtler *, Kristian W, Filbin *, Mariella G
Publicado 2023

An affinity for brainstem microglia in pediatric high-grade gliomas of brainstem origin

por Zats, Liat Peretz, Ahmad, Labiba, Casden, Natania, Lee, Meelim J, Belzer, Vitali, Adato, Orit, Bar Cohen, Shaked, Ko, Seung-Hyun B, Filbin, Mariella G, Unger, Ron, Lauffenburger, Douglas A, Segal, Rosalind A, Behar, Oded
Publicado 2022

ATRT-11. DEVELOPMENT OF NOVEL PRECLINICAL MODELS AND THERAPEUTIC STRATEGIES FOR ETMR

por Cocito, Carolina, Arias-Stella, Esteban Uceda, Zhang, Xiaohu, McKnight, Crystal, Itkin, Zina, Klumpp-Thomas, Carleen, Cruzeiro, Gustavo Alencastro Veiga, Chi, Susan N, Pisapia, David J, Filbin, Mariella G, Dahmane, Nadia, Thomas, Craig J, Greenfield, Jeffrey P
Publicado 2023

EPEN-11. CHARACTERIZATION OF THE SPATIAL ARCHITECTURE OF INTRATUMORAL CELL STATES IN PEDIATRIC HIGH-RISK EPENDYMOMA

por Bruckner, Katharina, Madlener, Sibylle, Biagi Junior, Carlos A O, Gabler, Lisa, Senfter, Daniel, Jeong, Daeun, Jiang, Li, Englinger, Bernhard, Jaunecker, Carola, Bilban, Martin, Haberler, Christine, Dorfer, Christian, Rössler, Karl, Kool, Marcel, Berger, Walter, Filbin, Mariella G, Lötsch-Gojo, Daniela, Gojo, Johannes
Publicado 2023

DIPG-64. INTERNATIONAL PRECLINICAL DRUG DISCOVERY AND BIOMARKER PROGRAM INFORMING AN ADOPTIVE COMBINATORIAL TRIAL FOR DIFFUSE MIDLINE GLIOMAS

por Przystal*, Justyna M, Yadavilli*, Sridevi, Abadi*, Christina Colman, Yadav, Viveka Nand, Laternser, Sandra, Cosentino, Chiara Cianciolo, Waszak, Sebastian M, Cartaxo, Rodrigo, Biery, Matt, Myers, Carrie, Jayasekara, Samantha, Olson, James M, Filbin, Mariella G, Vitanza, Nicholas A, Cain, Jason, Koschmann#, Carl, Müller#, Sabine, Nazarian#, Javad
Publicado 2020

ETMR-14. The single-cell landscape of pineoblastoma identifies developmental origins and exposes novel therapeutic vulnerabilities.

por Gudenas, Brian, Englinger, Bernhard, Liu, Anthony P Y, Ahmad, Sheikh Tanveer, Meredith, David, Pfaff, Elke, Paul, Leena, Hadley, Jennifer, Batts, Melissa, Klimo, Paul, Boop, Frederick A, Gajjar, Amar, Robinson, Giles, Orr, Brent, Lin, Hong, Alexandrescu, Sanda, Jones, David T W, Filbin, Mariella G, Northcott, Paul A
Publicado 2022

Molecular and clinicopathologic features of gliomas harboring NTRK fusions

por Torre, Matthew, Vasudevaraja, Varshini, Serrano, Jonathan, DeLorenzo, Michael, Malinowski, Seth, Blandin, Anne-Florence, Pages, Melanie, Ligon, Azra H., Dong, Fei, Meredith, David M., Nasrallah, MacLean P., Horbinski, Craig, Dahiya, Sonika, Ligon, Keith L., Santi, Mariarita, Ramkissoon, Shakti H., Filbin, Mariella G., Snuderl, Matija, Alexandrescu, Sanda
Publicado 2020