Characterization and Modeling of Reversible Antibody Self-Association Provide Insights into Behavior, Prediction, and Correction

por Mieczkowski, Carl, Cheng, Alan, Fischmann, Thierry, Hsieh, Mark, Baker, Jeanne, Uchida, Makiko, Raghunathan, Gopalan, Strickland, Corey, Fayadat-Dilman, Laurence
Publicado 2021

Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the E. coli FMN riboswitch

por Howe, John A., Xiao, Li, Fischmann, Thierry O., Wang, Hao, Tang, Haifeng, Villafania, Artjohn, Zhang, Rumin, Barbieri, Christopher M., Roemer, Terry
Publicado 2016

Pembrolizumab microgravity crystallization experimentation

por Reichert, Paul, Prosise, Winifred, Fischmann, Thierry O., Scapin, Giovanna, Narasimhan, Chakravarthy, Spinale, April, Polniak, Ray, Yang, Xiaoyu, Walsh, Erika, Patel, Daya, Benjamin, Wendy, Welch, Johnathan, Simmons, Denarra, Strickland, Corey
Publicado 2019

Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases

por Kleiner, Victoria A., O. Fischmann, Thierry, Howe, John A., Beshore, Douglas C., Eddins, Michael J., Hou, Yan, Mayhood, Todd, Klein, Daniel, Nahas, Debbie D., Lucas, Bob J., Xi, He, Murray, Edward, Ma, Daphne Y., Getty, Krista, Fearns, Rachel
Publicado 2023

Structural insights into selective small molecule activation of PKG1α

por Metwally, Essam, Mak, Victor, Soriano, Aileen, Zebisch, Matthias, Silvestre, H. Leonardo, McEwan, Paul A., Ermakov, Grigori, Beaumont, Maribel, Tawa, Paul, Barker, John J., Yen, Rose, Patel, Akash, Lim, Yeon-Hee, Healy, David, Hanisak, Jennifer, Cheng, Alan C., Greshock, Tom, Fischmann, Thierry O.
Publicado 2023

Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets

por Mann, Paul A., Müller, Anna, Wolff, Kerstin A., Fischmann, Thierry, Wang, Hao, Reed, Patricia, Hou, Yan, Li, Wenjin, Müller, Christa E., Xiao, Jianying, Murgolo, Nicholas, Sher, Xinwei, Mayhood, Todd, Sheth, Payal R., Mirza, Asra, Labroli, Marc, Xiao, Li, McCoy, Mark, Gill, Charles J., Pinho, Mariana G., Schneider, Tanja, Roemer, Terry
Publicado 2016

Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034

por Madison, Vincent, Prongay, Andrew J., Guo, Zhuyan, Yao, Nanhua, Pichardo, John, Fischmann, Thierry, Strickland, Corey, Myers Jr, Joseph, Weber, Patricia C., Beyer, Brian M., Ingram, Richard, Hong, Zhi, Prosise, Winifred W., Ramanathan, Lata, Taremi, S. Shane, Yarosh-Tomaine, Taisa, Zhang, Rumin, Senior, Mary, Yang, Rong-Sheng, Malcolm, Bruce, Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L., Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G., Saksena, Anil K., Venkatraman, Srikanth, Girijavallabhan, Viyyoor, Njoroge, F. George
Publicado 2008

Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy

por Guelen, Lars, Fischmann, Thierry O, Wong, Jerelyn, Mauze, Smita, Guadagnoli, Marco, Bąbała, Nikolina, Wagenaars, Jozef, Juan, Veronica, Rosen, David, Prosise, Winnie, Habraken, Maurice, Lodewijks, Imke, Gu, Danling, Stammen-Vogelzangs, Judith, Yu, Ying, Baker, Jeanne, Lutje Hulsik, David, Driessen-Engels, Lilian, Malashock, Dan, Kreijtz, Joost, Bertens, Astrid, de Vries, Evert, Bovens, Astrid, Bramer, Arne, Zhang, Yiwei, Wnek, Richard, Troth, Sean, Chartash, Elliot, Dobrenkov, Konstantin, Sadekova, Svetlana, van Elsas, Andrea, Cheung, Jason K, Fayadat-Dilman, Laurence, Borst, Jannie, Beebe, Amy M, Van Eenennaam, Hans
Publicado 2022