Rational Development and Characterization of a Ubiquitin Variant with Selectivity for Ubiquitin C-Terminal Hydrolase L3

por Hewitt, Chad S., Das, Chittaranjan, Flaherty, Daniel P.
Publicado 2022

Optimization of 2-Acylaminocycloalkylthiophene Derivatives for Activity against Staphylococcus aureus RnpA

por Chojnacki, Michaelle, Cao, Xufeng, Flaherty, Daniel P., Dunman, Paul M.
Publicado 2021

In vitro and in vivo activities of the carbonic anhydrase inhibitor, dorzolamide, against vancomycin-resistant enterococci

por Abutaleb, Nader S., Elhassanny, Ahmed E.M., Flaherty, Daniel P., Seleem, Mohamed N.
Publicado 2021

Anion inhibition studies of the α-carbonic anhydrases from Neisseria gonorrhoeae

por Nocentini, Alessio, Hewitt, Chad S., Mastrolorenzo, Margaret D., Flaherty, Daniel P., Supuran, Claudiu T.
Publicado 2021

Coumarins effectively inhibit bacterial α-carbonic anhydrases

por Giovannuzzi, Simone, Hewitt, Chad S., Nocentini, Alessio, Capasso, Clemente, Flaherty, Daniel P., Supuran, Claudiu T.
Publicado 2022

Identification of Small Molecule Inhibitors of Staphylococcus aureus RnpA

por Colquhoun, Jennifer M., Ha, Lisha, Beckley, Andrew, Meyers, Brinkley, Flaherty, Daniel P., Dunman, Paul M.
Publicado 2019

Inhibition studies of bacterial α-carbonic anhydrases with phenols

por Giovannuzzi, Simone, Hewitt, Chad S., Nocentini, Alessio, Capasso, Clemente, Costantino, Gabriele, Flaherty, Daniel P., Supuran, Claudiu T.
Publicado 2022

Dithiocarbamates effectively inhibit the α-carbonic anhydrase from Neisseria gonorrhoeae

por Giovannuzzi, Simone, Abutaleb, Nader S., Hewitt, Chad S., Carta, Fabrizio, Nocentini, Alessio, Seleem, Mohamed N., Flaherty, Daniel P., Supuran, Claudiu T.
Publicado 2021

Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype

por Dwyer, Tiffany S., O’Brien, Joseph B., Ptak, Christopher P., LaVigne, Justin E., Flaherty, Daniel P., Watts, Val J., Roman, David L.
Publicado 2022

Repurposing the Antihistamine Terfenadine for Antimicrobial Activity against Staphylococcus aureus

por Perlmutter, Jessamyn I., Forbes, Lauren T., Krysan, Damian J., Ebsworth-Mojica, Katherine, Colquhoun, Jennifer M., Wang, Jenna L., Dunman, Paul M., Flaherty, Daniel P.
Publicado 2014

Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of Neisseria gonorrhoeae

por Abutaleb, Nader S., Elhassanny, Ahmed E. M., Nocentini, Alessio, Hewitt, Chad S., Elkashif, Ahmed, Cooper, Bruce R., Supuran, Claudiu T., Seleem, Mohamed N., Flaherty, Daniel P.
Publicado 2021

Structure-activity relationship studies for inhibitors for vancomycin-resistant Enterococcus and human carbonic anhydrases

por An, Weiwei, Holly, Katrina J., Nocentini, Alessio, Imhoff, Ryan D., Hewitt, Chad. S., Abutaleb, Nader S., Cao, Xufeng, Seleem, Mohamed N., Supuran, Claudiu T., Flaherty, Daniel P.
Publicado 2022

Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1

por Krabill, Aaron D., Chen, Hao, Hussain, Sajjad, Hewitt, Chad S., Imhoff, Ryan D., Muli, Christine S., Das, Chittaranjan, Galardy, Paul J., Wendt, Michael K., Flaherty, Daniel P.
Publicado 2021

Carbonic Anhydrase Inhibition as a Target for Antibiotic Synergy in Enterococci

por Chilambi, Gayatri Shankar, Wang, Yu-Hao, Wallace, Nathan R., Obiwuma, Chetachukwu, Evans, Kirsten M., Li, Yanhong, Shalaby, Menna-Allah W., Flaherty, Daniel P., Shields, Ryan K., Doi, Yohei, Van Tyne, Daria
Publicado 2023

Optimization of Potent and Selective Quinazolinediones: Inhibitors of Respiratory Syncytial Virus That Block RNA-Dependent RNA-Polymerase Complex Activity

por Matharu, Daljit S., Flaherty, Daniel P., Simpson, Denise S., Schroeder, Chad E., Chung, Donghoon, Yan, Dan, Noah, James W., Jonsson, Colleen B., White, E. Lucile, Aubé, Jeffrey, Plemper, Richard K., Severson, William E., Golden, Jennifer E.
Publicado 2014

Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response

por Flaherty, Daniel P., Miller, Justin R., Garshott, Danielle M., Hedrick, Michael, Gosalia, Palak, Li, Yujie, Milewski, Monika, Sugarman, Eliot, Vasile, Stefan, Salaniwal, Sumeet, Su, Ying, Smith, Layton H., Chung, Thomas D. Y., Pinkerton, Anthony B., Aubé, Jeffrey, Callaghan, Michael U., Golden, Jennifer E., Fribley, Andrew M., Kaufman, Randal J.
Publicado 2014