Frizzled7: A Promising Achilles’ Heel for Targeting the Wnt Receptor Complex to Treat Cancer

por Phesse, Toby, Flanagan, Dustin, Vincan, Elizabeth
Publicado 2016

The Function of Lgr5(+) Cells in the Gastric Antrum Does Not Require Fzd7 or Myc In Vivo

por Flanagan, Dustin, Barker, Nick, Ernst, Matthias, Vincan, Elizabeth, Phesse, Toby
Publicado 2019

Wnt Signalling in Gastrointestinal Epithelial Stem Cells

por Flanagan, Dustin J., Austin, Chloe R., Vincan, Elizabeth, Phesse, Toby J.
Publicado 2018

Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibition

por Flanagan, Dustin J., Woodcock, Simon A., Phillips, Caroline, Eagle, Catherine, Sansom, Owen J.
Publicado 2022

Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo

por Flanagan, Dustin J., Barker, Nick, Nowell, Cameron, Clevers, Hans, Ernst, Matthias, Phesse, Toby J., Vincan, Elizabeth
Publicado 2017

The Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling

por Tran, Bang Manh, Flanagan, Dustin James, Ebert, Gregor, Warner, Nadia, Tran, Hoanh, Fifis, Theodora, Kastrappis, Georgios, Christophi, Christopher, Pellegrini, Marc, Torresi, Joseph, Phesse, Toby James, Vincan, Elizabeth
Publicado 2020

Calorie Restriction Increases the Number of Competing Stem Cells and Decreases Mutation Retention in the Intestine

por Bruens, Lotte, Ellenbroek, Saskia Inge Johanna, Suijkerbuijk, Saskia Jacoba Elisabeth, Azkanaz, Maria, Hale, Alexander James, Toonen, Pim, Flanagan, Dustin James, Sansom, Owen James, Snippert, Hugo Johannes, van Rheenen, Jacco
Publicado 2020

BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination

por Parker, Christopher, Chambers, Adam C., Flanagan, Dustin J., Ho, Jasmine Wing Yu, Collard, Tracey J., Ngo, Greg, Baird, Duncan M., Timms, Penny, Morgan, Rhys G., Sansom, Owen J., Williams, Ann C.
Publicado 2022

Caffeine Limits Expansion of Apc-Deficient Clones in the Intestine by NOTUM Inhibition

por van Driel, Milou S., Linssen, Jasmijn D.G., Flanagan, Dustin J., Vlahov, Nikola, Nijman, Lisanne E., de Groot, Nina E., Elbers, Clara C., Koster, Jan, Sansom, Owen J., Vermeulen, Louis, van Neerven, Sanne M.
Publicado 2023

Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas

por Heino, Sarika, Fang, Shentong, Lähde, Marianne, Högström, Jenny, Nassiri, Sina, Campbell, Andrew, Flanagan, Dustin, Raven, Alexander, Hodder, Michael, Nasreddin, Nadia, Xue, Hai-Hui, Delorenzi, Mauro, Leedham, Simon, Petrova, Tatiana V., Sansom, Owen, Alitalo, Kari
Publicado 2021

Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5(+) Stem Cells

por Flanagan, Dustin J., Phesse, Toby J., Barker, Nick, Schwab, Renate H.M., Amin, Nancy, Malaterre, Jordane, Stange, Daniel E., Nowell, Cameron J., Currie, Scott A., Saw, Jarel T.S., Beuchert, Eva, Ramsay, Robert G., Sansom, Owen J., Ernst, Matthias, Clevers, Hans, Vincan, Elizabeth
Publicado 2015

Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

por Holt, Amy K., Najumudeen, Arafath K., Collard, Tracey J., Li, Hao, Millett, Laura M., Hoskin, Ashley J., Legge, Danny N., Mortensson, Eleanor M. H., Flanagan, Dustin J., Jones, Nicholas, Kollareddy, Madhu, Timms, Penny, Hitchings, Matthew D., Cronin, James, Sansom, Owen J., Williams, Ann C., Vincent, Emma E.
Publicado 2023

Retrograde movements determine effective stem cell numbers in the intestine

por Azkanaz, Maria, Corominas-Murtra, Bernat, Ellenbroek, Saskia I.J., Bruens, Lotte, Webb, Anna T., Laskaris, Dimitrios, Oost, Koen C., Lafirenze, Simona J.A., Annusver, Karl, Messal, Hendrik A., Iqbal, Sharif, Flanagan, Dustin J., Huels, David J., Rojas-Rodríguez, Felipe, Vizoso, Miguel, Kasper, Maria, Sansom, Owen J., Snippert, Hugo J., Liberali, Prisca, Simons, Benjamin D., Katajisto, Pekka, Hannezo, Edouard, van Rheenen, Jacco
Publicado 2022

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia

por Gil Vazquez, Ester, Nasreddin, Nadia, Valbuena, Gabriel N., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Eggington, Holly R., Schenck, Ryan O., Wouters, Valérie M., Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R.M., Flanagan, Dustin J., Najumudeen, Arafath K., Omwenga, Sulochana, McCorry, Amy M.B., Easton, Alistair, Koelzer, Viktor H., East, James E., Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D., Loughrey, Maurice B., Dunne, Philip D., Tsantoulis, Petros, Huels, David J., Tejpar, Sabine, Sansom, Owen J., Leedham, Simon J.
Publicado 2022

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia

por Gil Vazquez, Ester, Nasreddin, Nadia, Valbuena, Gabriel N., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Eggington, Holly R., Schenck, Ryan O., Wouters, Valérie M., Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R.M., Flanagan, Dustin J., Najumudeen, Arafath K., Omwenga, Sulochana, McCorry, Amy M.B., Easton, Alistair, Koelzer, Viktor H., East, James E., Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D., Loughrey, Maurice B., Dunne, Philip D., Tsantoulis, Petros, Huels, David J., Tejpar, Sabine, Sansom, Owen J., Leedham, Simon J.
Publicado 2022

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

por Leach, Joshua D. G., Vlahov, Nikola, Tsantoulis, Petros, Ridgway, Rachel A., Flanagan, Dustin J., Gilroy, Kathryn, Sphyris, Nathalie, Vázquez, Ester G., Vincent, David F., Faller, William J., Hodder, Michael C., Raven, Alexander, Fey, Sigrid, Najumudeen, Arafath K., Strathdee, Douglas, Nixon, Colin, Hughes, Mark, Clark, William, Shaw, Robin, van Hooff, Sander R., Huels, David J., Medema, Jan Paul, Barry, Simon T., Frame, Margaret C., Unciti-Broceta, Asier, Leedham, Simon J., Inman, Gareth J., Jackstadt, Rene, Thompson, Barry J., Campbell, Andrew D., Tejpar, Sabine, Sansom, Owen J.
Publicado 2021

Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features

por Flanagan, Dustin J., Amirkhah, Raheleh, Vincent, David F., Gunduz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J., McCorry, Amy M. B., Fisher, Natalie C., Davis, Hayley L., Ridgway, Rachel A., Lohuis, Jeroen, Leach, Joshua D. G., Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K., Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L., Kerr, Emma M., Longley, Daniel B., Ginty, Fiona, Cho, Sanghee, Coleman, Helen G., Loughrey, Maurice B., Bardelli, Alberto, Maughan, Timothy S., Campbell, Andrew D., Lawler, Mark, Leedham, Simon J., Barry, Simon T., Inman, Gareth J., van Rheenen, Jacco, Dunne, Philip D., Sansom, Owen J.
Publicado 2022

Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features

por Flanagan, Dustin J., Amirkhah, Raheleh, Vincent, David F., Gunduz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J., McCorry, Amy M. B., Fisher, Natalie C., Davis, Hayley L., Ridgway, Rachel A., Lohuis, Jeroen, Leach, Joshua D. G., Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K., Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L., Kerr, Emma M., Longley, Daniel B., Ginty, Fiona, Cho, Sanghee, Coleman, Helen G., Loughrey, Maurice B., Bardelli, Alberto, Maughan, Timothy S., Campbell, Andrew D., Lawler, Mark, Leedham, Simon J., Barry, Simon T., Inman, Gareth J., van Rheenen, Jacco, Dunne, Philip D., Sansom, Owen J.
Publicado 2023