Plant-Derived Type I Ribosome Inactivating Protein-Based Targeted Toxins: A Review of the Clinical Experience

por Flavell, David J., Flavell, Sopsamorn U.
Publicado 2022

Characteristics and performance of a bispecific F (ab'gamma)2 antibody for delivering saporin to a CD7+ human acute T-cell leukaemia cell line.

por Flavell, D. J., Cooper, S., Morland, B., Flavell, S. U.
Publicado 1991

Effectiveness of combinations of bispecific antibodies for delivering saporin to human acute T-cell lymphoblastic leukaemia cell lines via CD7 and CD38 as cellular target molecules...

por Flavell, D. J., Cooper, S., Morland, B., French, R., Flavell, S. U.
Publicado 1992

Comparison of the potency and therapeutic efficacy of the anti-CD7 immunotoxin HB2-saporin constructed with one or two saporin moieties per immunotoxin molecule.

por Flavell, D. J., Boehm, D. A., Noss, A., Flavell, S. U.
Publicado 1997

Anti-CD7 antibody and immunotoxin treatment of human CD7(+)T-cell leukaemia is significantly less effective in NOD/LtSz-scid mice than in CB.17 scid mice

por Flavell, D J, Warnes, S L, Noss, A L, Flavell, S U
Publicado 2000

Therapy of human T-cell acute lymphoblastic leukaemia with a combination of anti-CD7 and anti-CD38-SAPORIN immunotoxins is significantly better than therapy with each individual im...

por Flavell, D J, Boehm, D A, Noss, A, Warnes, S L, Flavell, S U
Publicado 2001

The TLR3 Agonist Poly Inosinic:Cytidylic Acid Significantly Augments the Therapeutic Activity of an Anti-CD7 Immunotoxin for Human T-Cell Leukaemia

por Flavell, David J., Holmes, Suzanne E., Warnes, Sarah L, Flavell, Sopsamorn U.
Publicado 2019

The Effect of Small Molecule Pharmacological Agents on the Triterpenoid Saponin Induced Endolysosomal Escape of Saporin and a Saporin-Based Immunotoxin in Target Human Lymphoma Cel...

por Wensley, Harrison J., Smith, Wendy S., Holmes, Suzanne E., Flavell, Sopsamorn U., Flavell, David J.
Publicado 2021

Augmentation of Saporin-Based Immunotoxins for Human Leukaemia and Lymphoma Cells by Triterpenoid Saponins: The Modifying Effects of Small Molecule Pharmacological Agents

por Smith, Wendy S., Johnston, David A., Holmes, Suzanne E., Wensley, Harrison J., Flavell, Sopsamorn U., Flavell, David J.
Publicado 2019

A Flow Cytometric Method to Quantify the Endosomal Escape of a Protein Toxin to the Cytosol of Target Cells

por Wensley, Harrison J., Johnston, David A., Smith, Wendy S., Holmes, Suzanne E., Flavell, Sopsamorn U., Flavell, David J.
Publicado 2019

The Role of Cholesterol on Triterpenoid Saponin-Induced Endolysosomal Escape of a Saporin-Based Immunotoxin

por Smith, Wendy S., Johnston, David A., Wensley, Harrison J., Holmes, Suzanne E., Flavell, Sopsamorn U., Flavell, David J.
Publicado 2020

Effectiveness of HB2 (anti-CD7)--saporin immunotoxin in an in vivo model of human T-cell leukaemia developed in severe combined immunodeficient mice.

por Morland, B. J., Barley, J., Boehm, D., Flavell, S. U., Ghaleb, N., Kohler, J. A., Okayama, K., Wilkins, B., Flavell, D. J.
Publicado 1994

Preclinical studies with the anti-CD19-saporin immunotoxin BU12-SAPORIN for the treatment of human-B-cell tumours.

por Flavell, D. J., Flavell, S. U., Boehm, D. A., Emery, L., Noss, A., Ling, N. R., Richardson, P. R., Hardie, D., Wright, D. H.
Publicado 1995

Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera

por Errico Provenzano, Alfredo, Posteri, Riccardo, Giansanti, Francesco, Angelucci, Francesco, Flavell, Sopsamorn U., Flavell, David J., Fabbrini, Maria Serena, Porro, Danilo, Ippoliti, Rodolfo, Ceriotti, Aldo, Branduardi, Paola, Vago, Riccardo
Publicado 2016

Systematic comparison of single-chain Fv antibody-fusion toxin constructs containing Pseudomonas Exotoxin A or saporin produced in different microbial expression systems

por Della Cristina, Pietro, Castagna, Monica, Lombardi, Alessio, Barison, Erika, Tagliabue, Giovanni, Ceriotti, Aldo, Koutris, Ilias, Di Leandro, Luana, Giansanti, Francesco, Vago, Riccardo, Ippoliti, Rodolfo, Flavell, Sopsamorn U, Flavell, David J, Colombatti, Marco, Fabbrini, Maria Serena
Publicado 2015