What Have We Learned from Design of Function in Large Proteins?

por Khersonsky, Olga, Fleishman, Sarel J.
Publicado 2022

Editorial overview: Engineering and design

por Fleishman, Sarel J., Mariuzza, Roy A.
Publicado 2022

A lipophilicity-based energy function for membrane-protein modelling and design

por Weinstein, Jonathan Yaacov, Elazar, Assaf, Fleishman, Sarel Jacob
Publicado 2019

The AbDesign computational pipeline for modular backbone assembly and design of binders and enzymes

por Lipsh‐Sokolik, Rosalie, Listov, Dina, Fleishman, Sarel J.
Publicado 2020

A “Fuzzy”-Logic Language for Encoding Multiple Physical Traits in Biomolecules

por Warszawski, Shira, Netzer, Ravit, Tawfik, Dan S., Fleishman, Sarel J.
Publicado 2014

Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma

por Grossman, Iris, Ilani, Tal, Fleishman, Sarel Jacob, Fass, Deborah
Publicado 2016

Computational Enzyme Engineering Pipelines for Optimized Production of Renewable Chemicals

por Scherer, Marc, Fleishman, Sarel J., Jones, Patrik R., Dandekar, Thomas, Bencurova, Elena
Publicado 2021

Mutational scanning reveals the determinants of protein insertion and association energetics in the plasma membrane

por Elazar, Assaf, Weinstein, Jonathan, Biran, Ido, Fridman, Yearit, Bibi, Eitan, Fleishman, Sarel Jacob
Publicado 2016

Designed High-Redox Potential Laccases Exhibit High Functional Diversity

por Barber-Zucker, Shiran, Mateljak, Ivan, Goldsmith, Moshe, Kupervaser, Meital, Alcalde, Miguel, Fleishman, Sarel J.
Publicado 2022

Evolutionary paths that link orthogonal pairs of binding proteins

por Avizemer, Ziv, Martí-Gómez, Carlos, Hoch, Shlomo Yakir, McCandlish, David M., Fleishman, Sarel J.
Publicado 2023

Highly active enzymes by automated combinatorial backbone assembly and sequence design

por Lapidoth, Gideon, Khersonsky, Olga, Lipsh, Rosalie, Dym, Orly, Albeck, Shira, Rogotner, Shelly, Fleishman, Sarel J.
Publicado 2018

Assessing and enhancing foldability in designed proteins

por Listov, Dina, Lipsh‐Sokolik, Rosalie, Rosset, Stéphane, Yang, Che, Correia, Bruno E., Fleishman, Sarel Jacob
Publicado 2022

Stable and Functionally Diverse Versatile Peroxidases Designed Directly from Sequences

por Barber-Zucker, Shiran, Mindel, Vladimir, Garcia-Ruiz, Eva, Weinstein, Jonathan J., Alcalde, Miguel, Fleishman, Sarel J.
Publicado 2022

Repertoire of Computationally Designed Peroxygenases for Enantiodivergent C–H Oxyfunctionalization Reactions

por Gomez de Santos, Patricia, Mateljak, Ivan, Hoang, Manh Dat, Fleishman, Sarel J., Hollmann, Frank, Alcalde, Miguel
Publicado 2023

Ultrahigh specificity in a network of computationally designed protein-interaction pairs

por Netzer, Ravit, Listov, Dina, Lipsh, Rosalie, Dym, Orly, Albeck, Shira, Knop, Orli, Kleanthous, Colin, Fleishman, Sarel J.
Publicado 2018

The C-terminal tail of CSNAP attenuates the CSN complex

por Füzesi-Levi, Maria G, Ben-Nissan, Gili, Listov, Dina, Fridmann Sirkis, Yael, Hayouka, Zvi, Fleishman, Sarel, Sharon, Michal
Publicado 2023

Stabilization of the SARS-CoV-2 Receptor Binding Domain by Protein Core Redesign and Deep Mutational Scanning

por Leonard, Alison C., Weinstein, Jonathan J., Steiner, Paul J., Erbse, Annette H., Fleishman, Sarel J., Whitehead, Timothy A.
Publicado 2021

High Resolution Mapping of Protein Sequence–Function Relationships

por Fowler, Douglas M., Araya, Carlos L., Fleishman, Sarel J., Kellogg, Elizabeth H., Stephany, Jason J., Baker, David, Fields, Stanley
Publicado 2010

One-step sequence and structure-guided optimization of HIV-1 envelope gp140

por Malladi, Sameer Kumar, Schreiber, David, Pramanick, Ishika, Sridevi, Malavika Abhineshababu, Goldenzweig, Adi, Dutta, Somnath, Fleishman, Sarel Jacob, Varadarajan, Raghavan
Publicado 2020

Computational design of BclxL inhibitors that target transmembrane domain interactions

por Duart, Gerard, Elazar, Assaf, Weinstein, Jonathan Y., Gadea-Salom, Laura, Ortiz-Mateu, Juan, Fleishman, Sarel J., Mingarro, Ismael, Martinez-Gil, Luis
Publicado 2023