What Have We Learned from Design of Function in Large Proteins?

por Khersonsky, Olga, Fleishman, Sarel J.
Publicado 2022

Editorial overview: Engineering and design

por Fleishman, Sarel J., Mariuzza, Roy A.
Publicado 2022

The AbDesign computational pipeline for modular backbone assembly and design of binders and enzymes

por Lipsh‐Sokolik, Rosalie, Listov, Dina, Fleishman, Sarel J.
Publicado 2020

A “Fuzzy”-Logic Language for Encoding Multiple Physical Traits in Biomolecules

por Warszawski, Shira, Netzer, Ravit, Tawfik, Dan S., Fleishman, Sarel J.
Publicado 2014

Computational Enzyme Engineering Pipelines for Optimized Production of Renewable Chemicals

por Scherer, Marc, Fleishman, Sarel J., Jones, Patrik R., Dandekar, Thomas, Bencurova, Elena
Publicado 2021

Designed High-Redox Potential Laccases Exhibit High Functional Diversity

por Barber-Zucker, Shiran, Mateljak, Ivan, Goldsmith, Moshe, Kupervaser, Meital, Alcalde, Miguel, Fleishman, Sarel J.
Publicado 2022

Evolutionary paths that link orthogonal pairs of binding proteins

por Avizemer, Ziv, Martí-Gómez, Carlos, Hoch, Shlomo Yakir, McCandlish, David M., Fleishman, Sarel J.
Publicado 2023

Highly active enzymes by automated combinatorial backbone assembly and sequence design

por Lapidoth, Gideon, Khersonsky, Olga, Lipsh, Rosalie, Dym, Orly, Albeck, Shira, Rogotner, Shelly, Fleishman, Sarel J.
Publicado 2018

Stable and Functionally Diverse Versatile Peroxidases Designed Directly from Sequences

por Barber-Zucker, Shiran, Mindel, Vladimir, Garcia-Ruiz, Eva, Weinstein, Jonathan J., Alcalde, Miguel, Fleishman, Sarel J.
Publicado 2022

Repertoire of Computationally Designed Peroxygenases for Enantiodivergent C–H Oxyfunctionalization Reactions

por Gomez de Santos, Patricia, Mateljak, Ivan, Hoang, Manh Dat, Fleishman, Sarel J., Hollmann, Frank, Alcalde, Miguel
Publicado 2023

Ultrahigh specificity in a network of computationally designed protein-interaction pairs

por Netzer, Ravit, Listov, Dina, Lipsh, Rosalie, Dym, Orly, Albeck, Shira, Knop, Orli, Kleanthous, Colin, Fleishman, Sarel J.
Publicado 2018

Stabilization of the SARS-CoV-2 Receptor Binding Domain by Protein Core Redesign and Deep Mutational Scanning

por Leonard, Alison C., Weinstein, Jonathan J., Steiner, Paul J., Erbse, Annette H., Fleishman, Sarel J., Whitehead, Timothy A.
Publicado 2021

High Resolution Mapping of Protein Sequence–Function Relationships

por Fowler, Douglas M., Araya, Carlos L., Fleishman, Sarel J., Kellogg, Elizabeth H., Stephany, Jason J., Baker, David, Fields, Stanley
Publicado 2010

Computational design of BclxL inhibitors that target transmembrane domain interactions

por Duart, Gerard, Elazar, Assaf, Weinstein, Jonathan Y., Gadea-Salom, Laura, Ortiz-Mateu, Juan, Fleishman, Sarel J., Mingarro, Ismael, Martinez-Gil, Luis
Publicado 2023

Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases

por Zelnik, Iris D., Mestre, Beatriz, Weinstein, Jonathan J., Dingjan, Tamir, Izrailov, Stav, Ben-Dor, Shifra, Fleishman, Sarel J., Futerman, Anthony H.
Publicado 2023

Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction

por Adams, Ellen M., Pezzotti, Simone, Ahlers, Jonas, Rüttermann, Maximilian, Levin, Maxim, Goldenzweig, Adi, Peleg, Yoav, Fleishman, Sarel J., Sagi, Irit, Havenith, Martina
Publicado 2021

Rosetta in CAPRI rounds 13–19

por Fleishman, Sarel J, Corn, Jacob E, Strauch, Eva M, Whitehead, Tim A, Andre, Ingemar, Thompson, James, Havranek, James J, Das, Rhiju, Bradley, Philip, Baker, David
Publicado 2010

Protein quaternary structures in solution are a mixture of multiple forms

por Marciano, Shir, Dey, Debabrata, Listov, Dina, Fleishman, Sarel J., Sonn-Segev, Adar, Mertens, Haydyn, Busch, Florian, Kim, Yongseok, Harvey, Sophie R., Wysocki, Vicki H., Schreiber, Gideon
Publicado 2022

Rapid characterization of secreted recombinant proteins by native mass spectrometry

por Ben-Nissan, Gili, Vimer, Shay, Warszawski, Shira, Katz, Aliza, Yona, Meital, Unger, Tamar, Peleg, Yoav, Morgenstern, David, Cohen-Dvashi, Hadas, Diskin, Ron, Fleishman, Sarel J., Sharon, Michal
Publicado 2018

Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin

por Nikitin, Dmitri, Mican, Jan, Toul, Martin, Bednar, David, Peskova, Michaela, Kittova, Patricia, Thalerova, Sandra, Vitecek, Jan, Damborsky, Jiri, Mikulik, Robert, Fleishman, Sarel J., Prokop, Zbynek, Marek, Martin
Publicado 2022