Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation

por Levina, Aleksandra, Fleming, Kaelin D., Burke, John E., Leonard, Thomas A.
Publicado 2022

In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate

por Pokorny, Daniel, Truebestein, Linda, Fleming, Kaelin D., Burke, John E., Leonard, Thomas A.
Publicado 2021

Structure of autoinhibited Akt1 reveals mechanism of PIP(3)-mediated activation

por Truebestein, Linda, Hornegger, Harald, Anrather, Dorothea, Hartl, Markus, Fleming, Kaelin D., Stariha, Jordan T. B., Pardon, Els, Steyaert, Jan, Burke, John E., Leonard, Thomas A.
Publicado 2021

Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

por Rathinaswamy, Manoj K, Gaieb, Zied, Fleming, Kaelin D, Borsari, Chiara, Harris, Noah J, Moeller, Brandon E, Wymann, Matthias P, Amaro, Rommie E, Burke, John E
Publicado 2021

The substrate specificity of the human TRAPPII complex’s Rab-guanine nucleotide exchange factor activity

por Jenkins, Meredith L., Harris, Noah J., Dalwadi, Udit, Fleming, Kaelin D., Ziemianowicz, Daniel S., Rafiei, Atefeh, Martin, Emily M., Schriemer, David C., Yip, Calvin K., Burke, John E.
Publicado 2020

The middle lipin domain adopts a membrane-binding dimeric protein fold

por Gu, Weijing, Gao, Shujuan, Wang, Huan, Fleming, Kaelin D., Hoffmann, Reece M., Yang, Jong Won, Patel, Nimi M., Choi, Yong Mi, Burke, John E., Reue, Karen, Airola, Michael V.
Publicado 2021

Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation

por Rathinaswamy, Manoj K., Dalwadi, Udit, Fleming, Kaelin D., Adams, Carson, Stariha, Jordan T. B., Pardon, Els, Baek, Minkyung, Vadas, Oscar, DiMaio, Frank, Steyaert, Jan, Hansen, Scott D., Yip, Calvin K., Burke, John E.
Publicado 2021

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation

por Choi, Yong Mi, Ajjaji, Dalila, Fleming, Kaelin D., Borbat, Peter P., Jenkins, Meredith L., Moeller, Brandon E., Fernando, Shaveen, Bhatia, Surita R., Freed, Jack H., Burke, John E., Thiam, Abdou Rachid, Airola, Michael V.
Publicado 2023

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

por Rathinaswamy, Manoj K., Jenkins, Meredith L., Duewell, Benjamin R., Zhang, Xuxiao, Harris, Noah J., Evans, John T., Stariha, Jordan T.B., Dalwadi, Udit, Fleming, Kaelin D., Ranga-Prasad, Harish, Yip, Calvin K., Williams, Roger L., Hansen, Scott D., Burke, John E.
Publicado 2023