Sexual Dimorphism of the Mouse Plasma Metabolome Is Associated with Phenotypes of 30 Gene Knockout Lines

por Zhang, Ying, Barupal, Dinesh K., Fan, Sili, Gao, Bei, Zhu, Chao, Flenniken, Ann M., McKerlie, Colin, Nutter, Lauryl M. J., Lloyd, Kevin C. Kent, Fiehn, Oliver
Publicado 2023

The ATP6V1B2 DDOD/DOORS-Associated p.Arg506* Variant Causes Hyperactivity and Seizures in Mice

por Rousseau, Justine, Tene Tadoum, Samuel Boris, Lavertu Jolin, Marisol, Nguyen, Thi Tuyet Mai, Ajeawung, Norbert Fonya, Flenniken, Ann M., Nutter, Lauryl M. J., Vukobradovic, Igor, Rossignol, Elsa, Campeau, Philippe M.
Publicado 2023

Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma

por Mohammed, Yassene, Michaud, Sarah A., Pětrošová, Helena, Yang, Juncong, Ganguly, Milan, Schibli, David, Flenniken, Ann M., Nutter, Lauryl M. J., Adissu, Hibret A., Lloyd, K. C. Kent, McKerlie, Colin, Borchers, Christoph H.
Publicado 2021

Genome-wide screening of mouse knockouts reveals novel genes required for normal integumentary and oculocutaneous structure and function

por Moore, Bret A., Flenniken, Ann M., Clary, Dave, Moshiri, Ata S., Nutter, Lauryl M. J., Berberovic, Zorana, Owen, Celeste, Newbigging, Susan, Adissu, Hibret, Eskandarian, Mohammad, McKerlie, Colin, Thomasy, Sara M., Lloyd, K. C. Kent, Murphy, Christopher J., Moshiri, Ala
Publicado 2019

Enu Mutagenesis Identifies a Novel Platelet Phenotype in a Loss-Of-Function Jak2 Allele

por Anderson, Nicole M., Javadi, Mojib, Berndl, Elizabeth, Berberovic, Zorana, Bailey, Monica L., Huang, Kai, Flenniken, Ann M., Osborne, Lucy R., Adamson, S. Lee, Rossant, Janet, Carter-Su, Christin, Wang, Chen, McNagny, Kelly M., Paulson, Robert F., Minden, Mark D., Stanford, William L., Barber, Dwayne L.
Publicado 2013

The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities

por Herbert, Eleanor, Stewart, Michelle, Hutchison, Marie, Flenniken, Ann M., Qu, Dawei, Nutter, Lauryl M. J., McKerlie, Colin, Hobson, Liane, Kick, Brenda, Lyons, Bonnie, Wiegand, Jean-Paul, Doty, Rosalinda, Aguilar-Pimentel, Juan Antonio, Hrabe de Angelis, Martin, Dickinson, Mary, Seavitt, John, White, Jacqueline K., Scudamore, Cheryl L., Wells, Sara
Publicado 2020

A Comprehensive Plasma Metabolomics Dataset for a Cohort of Mouse Knockouts within the International Mouse Phenotyping Consortium

por Barupal, Dinesh K., Zhang, Ying, Shen, Tong, Fan, Sili, Roberts, Bryan S., Fitzgerald, Patrick, Wancewicz, Benjamin, Valdiviez, Luis, Wohlgemuth, Gert, Byram, Gregory, Choy, Ying Yng, Haffner, Bennett, Showalter, Megan R., Vaniya, Arpana, Bloszies, Clayton S., Folz, Jacob S., Kind, Tobias, Flenniken, Ann M., McKerlie, Colin, Nutter, Lauryl M. J., Lloyd, Kent C., Fiehn, Oliver
Publicado 2019

ENU-induced Mutation in the DNA-binding Domain of KLF3 Reveals Important Roles for KLF3 in Cardiovascular Development and Function in Mice

por Kelsey, Lois, Flenniken, Ann M., Qu, Dawei, Funnell, Alister P. W., Pearson, Richard, Zhou, Yu-Qing, Voronina, Irina, Berberovic, Zorana, Wood, Geoffrey, Newbigging, Susan, Weiss, Edward S., Wong, Michael, Quach, Ivan, Yeh, S. Y. Sandy, Deshwar, Ashish R., Scott, Ian C., McKerlie, Colin, Henkelman, Mark, Backx, Peter, Simpson, Jeremy, Osborne, Lucy, Rossant, Janet, Crossley, Merlin, Bruneau, Benoit, Adamson, S. Lee
Publicado 2013

INFRAFRONTIER quality principles in systemic phenotyping

por Ehlich, Hilke, Cater, Heather L., Flenniken, Ann M., Goncalves Da Cruz, Isabelle, Mura, Anne-Marie, Ntafis, Vasileios, Raess, Michael, Selloum, Mohammed, Stoeger, Claudia, Suchanova, Sarka, Vuolteenaho, Reetta, Brown, Steve D. M., Hérault, Yann, Hinttala, Reetta, Hrabě de Angelis, Martin, Kollias, George, Kontoyiannis, Dimitris L., Malissen, Bernard, McKerlie, Colin, Sedláček, Radislav, Wells, Sara E., Zarubica, Ana, Rozman, Jan, Sorg, Tania
Publicado 2021

The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation

por Muñoz-Fuentes, Violeta, Cacheiro, Pilar, Meehan, Terrence F., Aguilar-Pimentel, Juan Antonio, Brown, Steve D. M., Flenniken, Ann M., Flicek, Paul, Galli, Antonella, Mashhadi, Hamed Haseli, Hrabě de Angelis, Martin, Kim, Jong Kyoung, Lloyd, K. C. Kent, McKerlie, Colin, Morgan, Hugh, Murray, Stephen A., Nutter, Lauryl M. J., Reilly, Patrick T., Seavitt, John R., Seong, Je Kyung, Simon, Michelle, Wardle-Jones, Hannah, Mallon, Ann-Marie, Smedley, Damian, Parkinson, Helen E.
Publicado 2018

Cage-lid hanging behavior as a translationally relevant measure of pain in mice

por Zhang, Hantao, Lecker, Irene, Collymore, Chereen, Dokova, Anastassia, Pham, Maian Christine, Rosen, Sarah F., Crawhall-Duk, Hayley, Zain, Maham, Valencia, Megan, Filippini, Helena Fetter, Li, Jerry, D'Souza, Abigail J., Cho, Chulmin, Michailidis, Vassilia, Whissell, Paul D., Patel, Ingita, Steenland, Hendrik W., Virginia Lee, Wai-Jane, Moayedi, Massieh, Sterley, Toni-Lee, Bains, Jaideep S., Stratton, Jo Anne, Matyas, John R., Biernaskie, Jeff, Dubins, David, Vukobradovic, Igor, Bezginov, Alexandr, Flenniken, Ann M., Martin, Loren J., Mogil, Jeffrey S., Bonin, Robert P.
Publicado 2021

Applying the ARRIVE Guidelines to an In Vivo Database

por Karp, Natasha A., Meehan, Terry F., Morgan, Hugh, Mason, Jeremy C., Blake, Andrew, Kurbatova, Natalja, Smedley, Damian, Jacobsen, Julius, Mott, Richard F., Iyer, Vivek, Matthews, Peter, Melvin, David G., Wells, Sara, Flenniken, Ann M., Masuya, Hiroshi, Wakana, Shigeharu, White, Jacqueline K., Lloyd, K. C. Kent, Reynolds, Corey L., Paylor, Richard, West, David B., Svenson, Karen L., Chesler, Elissa J., de Angelis, Martin Hrabě, Tocchini-Valentini, Glauco P., Sorg, Tania, Herault, Yann, Parkinson, Helen, Mallon, Ann-Marie, Brown, Steve D. M.
Publicado 2015

Mendelian gene identification through mouse embryo viability screening

por Cacheiro, Pilar, Westerberg, Carl Henrik, Mager, Jesse, Dickinson, Mary E., Nutter, Lauryl M. J., Muñoz-Fuentes, Violeta, Hsu, Chih-Wei, Van den Veyver, Ignatia B., Flenniken, Ann M., McKerlie, Colin, Murray, Stephen A., Teboul, Lydia, Heaney, Jason D., Lloyd, K. C. Kent, Lanoue, Louise, Braun, Robert E., White, Jacqueline K., Creighton, Amie K., Laurin, Valerie, Guo, Ruolin, Qu, Dawei, Wells, Sara, Cleak, James, Bunton-Stasyshyn, Rosie, Stewart, Michelle, Harrisson, Jackie, Mason, Jeremy, Haseli Mashhadi, Hamed, Parkinson, Helen, Mallon, Ann-Marie, Smedley, Damian
Publicado 2022

High-throughput discovery of genetic determinants of circadian misalignment

por Zhang, Tao, Xie, Pancheng, Dong, Yingying, Liu, Zhiwei, Zhou, Fei, Pan, Dejing, Huang, Zhengyun, Zhai, Qiaocheng, Gu, Yue, Wu, Qingyu, Tanaka, Nobuhiko, Obata, Yuichi, Bradley, Allan, Lelliott, Christopher J., Nutter, Lauryl M. J., McKerlie, Colin, Flenniken, Ann M., Champy, Marie-France, Sorg, Tania, Herault, Yann, Angelis, Martin Hrabe De, Durner, Valerie Gailus, Mallon, Ann-Marie, Brown, Steve D. M., Meehan, Terry, Parkinson, Helen E., Smedley, Damian, Lloyd, K. C. Kent, Yan, Jun, Gao, Xiang, Seong, Je Kyung, Wang, Chi-Kuang Leo, Sedlacek, Radislav, Liu, Yi, Rozman, Jan, Yang, Ling, Xu, Ying
Publicado 2020

Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes

por Higgins, Kendall, Moore, Bret A., Berberovic, Zorana, Adissu, Hibret A., Eskandarian, Mohammad, Flenniken, Ann M., Shao, Andy, Imai, Denise M., Clary, Dave, Lanoue, Louise, Newbigging, Susan, Nutter, Lauryl M. J., Adams, David J., Bosch, Fatima, Braun, Robert E., Brown, Steve D. M., Dickinson, Mary E., Dobbie, Michael, Flicek, Paul, Gao, Xiang, Galande, Sanjeev, Grobler, Anne, Heaney, Jason D., Herault, Yann, de Angelis, Martin Hrabe, Chin, Hsian-Jean Genie, Mammano, Fabio, Qin, Chuan, Shiroishi, Toshihiko, Sedlacek, Radislav, Seong, J.-K., Xu, Ying, Lloyd, K. C. Kent, McKerlie, Colin, Moshiri, Ala
Publicado 2022

Prevalence of sexual dimorphism in mammalian phenotypic traits

por Karp, Natasha A., Mason, Jeremy, Beaudet, Arthur L., Benjamini, Yoav, Bower, Lynette, Braun, Robert E., Brown, Steve D.M., Chesler, Elissa J., Dickinson, Mary E., Flenniken, Ann M., Fuchs, Helmut, Angelis, Martin Hrabe de, Gao, Xiang, Guo, Shiying, Greenaway, Simon, Heller, Ruth, Herault, Yann, Justice, Monica J., Kurbatova, Natalja, Lelliott, Christopher J., Lloyd, K.C. Kent, Mallon, Ann-Marie, Mank, Judith E., Masuya, Hiroshi, McKerlie, Colin, Meehan, Terrence F., Mott, Richard F., Murray, Stephen A., Parkinson, Helen, Ramirez-Solis, Ramiro, Santos, Luis, Seavitt, John R., Smedley, Damian, Sorg, Tania, Speak, Anneliese O., Steel, Karen P., Svenson, Karen L., Wakana, Shigeharu, West, David, Wells, Sara, Westerberg, Henrik, Yaacoby, Shay, White, Jacqueline K.
Publicado 2017

Human and mouse essentiality screens as a resource for disease gene discovery

por Cacheiro, Pilar, Muñoz-Fuentes, Violeta, Murray, Stephen A., Dickinson, Mary E., Bucan, Maja, Nutter, Lauryl M. J., Peterson, Kevin A., Haselimashhadi, Hamed, Flenniken, Ann M., Morgan, Hugh, Westerberg, Henrik, Konopka, Tomasz, Hsu, Chih-Wei, Christiansen, Audrey, Lanza, Denise G., Beaudet, Arthur L., Heaney, Jason D., Fuchs, Helmut, Gailus-Durner, Valerie, Sorg, Tania, Prochazka, Jan, Novosadova, Vendula, Lelliott, Christopher J., Wardle-Jones, Hannah, Wells, Sara, Teboul, Lydia, Cater, Heather, Stewart, Michelle, Hough, Tertius, Wurst, Wolfgang, Sedlacek, Radislav, Adams, David J., Seavitt, John R., Tocchini-Valentini, Glauco, Mammano, Fabio, Braun, Robert E., McKerlie, Colin, Herault, Yann, de Angelis, Martin Hrabě, Mallon, Ann-Marie, Lloyd, K. C.  Kent, Brown, Steve D. M., Parkinson, Helen, Meehan, Terrence F., Smedley, Damian
Publicado 2020

The Deep Genome Project

por Lloyd, K. C. Kent, Adams, David J., Baynam, Gareth, Beaudet, Arthur L., Bosch, Fatima, Boycott, Kym M., Braun, Robert E., Caulfield, Mark, Cohn, Ronald, Dickinson, Mary E., Dobbie, Michael S., Flenniken, Ann M., Flicek, Paul, Galande, Sanjeev, Gao, Xiang, Grobler, Anne, Heaney, Jason D., Herault, Yann, de Angelis, Martin Hrabě, Lupski, James R., Lyonnet, Stanislas, Mallon, Ann-Marie, Mammano, Fabio, MacRae, Calum A., McInnes, Roderick, McKerlie, Colin, Meehan, Terrence F., Murray, Stephen A., Nutter, Lauryl M. J., Obata, Yuichi, Parkinson, Helen, Pepper, Michael S., Sedlacek, Radislav, Seong, Je Kyung, Shiroishi, Toshihiko, Smedley, Damian, Tocchini-Valentini, Glauco, Valle, David, Wang, Chi-Kuang Leo, Wells, Sara, White, Jacqueline, Wurst, Wolfgang, Xu, Ying, Brown, Steve D. M.
Publicado 2020

Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice

por Oestereicher, Manuela A., Wotton, Janine M., Ayabe, Shinya, Bou About, Ghina, Cheng, Tsz Kwan, Choi, Jae-Hoon, Clary, Dave, Dew, Emily M., Elfertak, Lahcen, Guimond, Alain, Haseli Mashhadi, Hamed, Heaney, Jason D., Kelsey, Lois, Keskivali-Bond, Piia, Lopez Gomez, Federico, Marschall, Susan, McFarland, Michael, Meziane , Hamid, Munoz Fuentes, Violeta, Nam , Ki-Hoan, Nichtová, Zuzana, Pimm, Dale, Bower, Lynette, Prochazka, Jan, Rozman, Jan, Santos, Luis, Stewart, Michelle, Tanaka, Nobuhiko, Ward, Christopher S., Willett, Amelia M. E., Wilson, Robert, Braun, Robert E., Dickinson, Mary E., Flenniken, Ann M., Herault, Yann, Lloyd, K. C. Kent, Mallon, Ann-Marie, McKerlie, Colin, Murray, Stephen A., Nutter, Lauryl M. J., Sedlacek, Radislav, Seong, Je Kyung, Sorg, Tania, Tamura, Masaru, Wells, Sara, Schneltzer, Elida, Fuchs, Helmut, Gailus-Durner, Valerie, Hrabe de Angelis, Martin, White, Jacqueline K., Spielmann, Nadine
Publicado 2023

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction

por Bowl, Michael R., Simon, Michelle M., Ingham, Neil J., Greenaway, Simon, Santos, Luis, Cater, Heather, Taylor, Sarah, Mason, Jeremy, Kurbatova, Natalja, Pearson, Selina, Bower, Lynette R., Clary, Dave A., Meziane, Hamid, Reilly, Patrick, Minowa, Osamu, Kelsey, Lois, Tocchini-Valentini, Glauco P., Gao, Xiang, Bradley, Allan, Skarnes, William C., Moore, Mark, Beaudet, Arthur L., Justice, Monica J., Seavitt, John, Dickinson, Mary E., Wurst, Wolfgang, de Angelis, Martin Hrabe, Herault, Yann, Wakana, Shigeharu, Nutter, Lauryl M. J., Flenniken, Ann M., McKerlie, Colin, Murray, Stephen A., Svenson, Karen L., Braun, Robert E., West, David B., Lloyd, K. C. Kent, Adams, David J., White, Jacqui, Karp, Natasha, Flicek, Paul, Smedley, Damian, Meehan, Terrence F., Parkinson, Helen E., Teboul, Lydia M., Wells, Sara, Steel, Karen P., Mallon, Ann-Marie, Brown, Steve D. M.
Publicado 2017