A hyperinflammation clinical risk tool, HI5-NEWS2, stratifies hospitalised COVID-19 patients to associate risk of death and effect of early dexamethasone in an observational cohort

por Ardern-Jones, Michael R., Phan, Hang T. T., Borca, Florina, Stammers, Matt, Batchelor, James, Reading, Isabel C., Fletcher, Sophie V., Smith, Trevor, Duncombe, Andrew S.
Publicado 2023

Noninvasive ventilation for COVID-19-associated acute hypoxaemic respiratory failure: experience from a single centre

por Sivaloganathan, Arjjana A., Nasim-Mohi, Myra, Brown, Michael M., Abdul, Nabil, Jackson, Alexander, Fletcher, Sophie V., Gupta, Sanjay, Grocott, Michael P.W., Dushianthan, Ahilanandan
Publicado 2020

Individualised Exercise Training Enhances Antioxidant Buffering Capacity in Idiopathic Pulmonary Fibrosis

por Wallis, Tim J. M., Minnion, Magdalena, Freeman, Anna, Bates, Andrew, Otto, James M., Wootton, Stephen A., Fletcher, Sophie V., Grocott, Michael P. W., Feelisch, Martin, Jones, Mark G., Jack, Sandy
Publicado 2023

Paracrine SPARC signaling dysregulates alveolar epithelial barrier integrity and function in lung fibrosis

por Conforti, Franco, Ridley, Robert, Brereton, Christopher, Alzetani, Aiman, Johnson, Benjamin, Marshall, Ben G., Fletcher, Sophie V., Ottensmeier, Christian H., Richeldi, Luca, Skipp, Paul, Wang, Yihua, Jones, Mark G., Davies, Donna E.
Publicado 2020

Spatially resolved deconvolution of the fibrotic niche in lung fibrosis

por Eyres, Michael, Bell, Joseph A., Davies, Elizabeth R., Fabre, Aurelie, Alzetani, Aiman, Jogai, Sanjay, Marshall, Ben G., Johnston, David A., Xu, Zijian, Fletcher, Sophie V., Wang, Yihua, Marshall, Gayle, Davies, Donna E., Offer, Emily, Jones, Mark G.
Publicado 2022

Temporal progression of mediastinal lymphadenopathy in idiopathic pulmonary fibrosis

por Wallis, Tim JM, Gudmundsson, Eyjólfur, Pontoppidan, Katarina, Mogulkoc, Nesrin, Savaş, Recep, Unat, Ömer Selim, Vedwan, Katharine, Battison, Sobana, Thompson, Fiona J, Brereton, Christopher J, Marshall, Ben G, Fletcher, Sophie V, Richeldi, Luca, Jacob, Joseph, Jones, Mark G
Publicado 2022

Time taken from primary care referral to a specialist centre diagnosis of idiopathic pulmonary fibrosis: an opportunity to improve patient outcomes?

por Brereton, Christopher J., Wallis, Timothy, Casey, Michelle, Fox, Lynn, Pontopiddan, Katarina, Laws, Diane, Graves, Jennifer, Titmuss, Vanessa, Kearney, Sarah, Evans, Sian, Grove, Alison, Hamid, Samreen, Richeldi, Luca, O'Reilly, Katherine M.A., Fletcher, Sophie V., Jones, Mark G.
Publicado 2020

Safety and tolerability of nintedanib for the treatment of idiopathic pulmonary fibrosis in routine UK clinical practice

por Fletcher, Sophie V., Jones, Mark G., Renzoni, Elizabeth A., Parfrey, Helen, Hoyles, Rachel K., Spinks, Katherine, Kokosi, Maria, Kwok, Apollinaris, Warburton, Chris, Titmuss, Vanessa, Thillai, Muhunthan, Simler, Nicola, Maher, Toby M., Brereton, Christopher J., Chua, Felix, Wells, Athol U., Richeldi, Luca, Spencer, Lisa G.
Publicado 2018

Bidirectional epithelial–mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis

por Yao, Liudi, Zhou, Yilu, Li, Juanjuan, Wickens, Leanne, Conforti, Franco, Rattu, Anna, Ibrahim, Fathima Maneesha, Alzetani, Aiman, Marshall, Ben G., Fletcher, Sophie V., Hancock, David, Wallis, Tim, Downward, Julian, Ewing, Rob M., Richeldi, Luca, Skipp, Paul, Davies, Donna E., Jones, Mark G., Wang, Yihua
Publicado 2021

Autophagy inhibition-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis

por Hill, Charlotte, Li, Juanjuan, Liu, Dian, Conforti, Franco, Brereton, Christopher J., Yao, Liudi, Zhou, Yilu, Alzetani, Aiman, Chee, Serena J., Marshall, Ben G., Fletcher, Sophie V., Hancock, David, Ottensmeier, Christian H., Steele, Andrew J., Downward, Julian, Richeldi, Luca, Lu, Xin, Davies, Donna E., Jones, Mark G., Wang, Yihua
Publicado 2019

Paracrine signalling during ZEB1-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in lung fibrosis

por Yao, Liudi, Conforti, Franco, Hill, Charlotte, Bell, Joseph, Drawater, Leena, Li, Juanjuan, Liu, Dian, Xiong, Hua, Alzetani, Aiman, Chee, Serena J., Marshall, Ben G., Fletcher, Sophie V., Hancock, David, Coldwell, Mark, Yuan, Xianglin, Ottensmeier, Christian H., Downward, Julian, Collins, Jane E., Ewing, Rob M., Richeldi, Luca, Skipp, Paul, Jones, Mark G., Davies, Donna E., Wang, Yihua
Publicado 2018

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

por Brereton, Christopher J, Yao, Liudi, Davies, Elizabeth R, Zhou, Yilu, Vukmirovic, Milica, Bell, Joseph A, Wang, Siyuan, Ridley, Robert A, Dean, Lareb SN, Andriotis, Orestis G, Conforti, Franco, Brewitz, Lennart, Mohammed, Soran, Wallis, Timothy, Tavassoli, Ali, Ewing, Rob M, Alzetani, Aiman, Marshall, Benjamin G, Fletcher, Sophie V, Thurner, Philipp J, Fabre, Aurelie, Kaminski, Naftali, Richeldi, Luca, Bhaskar, Atul, Schofield, Christopher J, Loxham, Matthew, Davies, Donna E, Wang, Yihua, Jones, Mark G
Publicado 2022

Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis

por Jones, Mark G, Andriotis, Orestis G, Roberts, James JW, Lunn, Kerry, Tear, Victoria J, Cao, Lucy, Ask, Kjetil, Smart, David E, Bonfanti, Alessandra, Johnson, Peter, Alzetani, Aiman, Conforti, Franco, Doherty, Regan, Lai, Chester Y, Johnson, Benjamin, Bourdakos, Konstantinos N, Fletcher, Sophie V, Marshall, Ben G, Jogai, Sanjay, Brereton, Christopher J, Chee, Serena J, Ottensmeier, Christian H, Sime, Patricia, Gauldie, Jack, Kolb, Martin, Mahajan, Sumeet, Fabre, Aurelie, Bhaskar, Atul, Jarolimek, Wolfgang, Richeldi, Luca, O'Reilly, Katherine MA, Monk, Phillip D, Thurner, Philipp J, Davies, Donna E
Publicado 2018